Abstract: Systems and methods for measuring a topography of an optical tissue surface of an eye are provided by combining a measured elevation of the surface with a priori information of the surface to provide an estimate of mean and covariance of post-measurement orthogonal polynomial sequence amplitudes associated with the surface, determining a variance of elevation of the surface from the estimate, and constructing the topography from the estimate of mean and covariance of post-measurement amplitudes based on a comparison of the variance of elevation of the surface with a pre-determined threshold. The a priori information includes an estimate of mean and covariance of pre-measurement orthogonal polynomial sequence amplitudes associated with the surface.

Abstract: Systems and methods for measuring a topography of an optical tissue surface of an eye are provided by combining measured elevations of the surface with a priori information of the surface to provide an estimate of mean and covariance of post-measurement orthogonal polynomial sequence amplitudes associated with the surface, determining a variance of elevation of the surface from the estimate, and constructing the topography from the estimate of mean and covariance of post-measurement amplitudes based on a comparison of the variance of elevation of the surface with a pre-determined threshold. The a priori information includes an estimate of mean and covariance of pre-measurement orthogonal polynomial sequence amplitudes associated with the surface.

Abstract: Systems and methods for fine-tuning refractive shapes for vision treatment are provided. Techniques encompass determining a variable index of refraction for a cornea of the eye, and determining the refractive treatment shape for the eye based on the variable index of refraction. Techniques also encompass determining a variable radius of curvature of an anterior surface of a cornea of the eye, and determining the refractive treatment shape for the eye based on the variable radius of curvature.

Abstract: Methods and systems for ablating internal targets in the eye of a patient employ an ophthalmic measurement system to acquire location data of structures in the eye. A controller calculates target locations based on the location data received from the ophthalmic measurement system, and a laser emits a laser beam to treat the target locations received from the controller. A patient interface is attached to the eye to provide a common reference surface for both the laser and the ophthalmic measurement system. The patient interface may engage the eye around the optically used cornea, and without conforming the optically used cornea to a predetermined shape.

Abstract: An ophthalmic patient interface system includes an interface device and an ocular device. The interface device includes a frame having a first end and a second end, a lens disposed at the first end, and a skirt affixed to the first end. The second end is adapted to couple with a surgical laser system, and the skirt is adapted to seal against an anterior surface of an eye. The ocular device includes magnifying optics and is adapted to be removably seated within the second end. The magnifying optics image a region on a corneal side of the lens when the ocular device is seated within the second end.