Patents by Inventor Amos B. Smith

Amos B. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR THE TREATMENT AND PREVENTION OF HIV
    Publication number: 20260001844
    Abstract: Compositions and methods for treating HIV using compounds that sensitize HIV-1 infected cells to antibody-dependent cellular cytotoxicity.
    Type: Application
    Filed: May 23, 2023
    Publication date: January 1, 2026
    Inventors: Amos B. SMITH, Andrés FINZI, Shilei DING, Tyler HIGGINS, Xuchen ZHAO, Daniel LEE, Marzena PAZGIER, Dung N. NGUYEN, William D. TOLBERT
  • SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE
    Publication number: 20170210766
    Abstract: Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
    Type: Application
    Filed: July 16, 2015
    Publication date: July 27, 2017
    Inventors: Adam T. HOYE, Won-Suk KIM, Dionicio MARTINEZ-SOLORIO, Amos B. SMITH, Rongbiao TONG, Minh Huu NGUYEN, Luis SANCHEZ, Bruno Nicolas MELILLO
  • Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
    Patent number: 9649317
    Abstract: The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds which are microtubule-stabilizing compounds and their use in the treatment of neurodegenerative disorders, in particular, tauopathies, such as for example, Alzheimer's disease, frontotemporal lobar degeneration, Pick's disease, progressive supranuclear palsy (PSP), and corticobasal degeneration. In addition, the compounds of the invention may be useful for other diseases where tau pathology is a comorbidity or where microtubule function is compromised, for example, schizophrenia, Parkinson's disease (PD), PD with dementia, Lewy body disease with dementia, and amyotrophic lateral sclerosis.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: May 16, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carlo Ballatore, Kurt R. Brunden, Adam T. Hoye, Virginia M. Y. Lee, Amos B. Smith, John Q. Trojanowski
  • CD4-MIMETIC SMALL MOLECULES SENSITIZE HUMAN IMMUNODEFICIENCY VIRUS TO VACCINE-ELICITED ANTIBODIES
    Publication number: 20160362478
    Abstract: Described herein are methods of generating a protein binding domain that specifically binds to gp120 in a specific conformational state, comprising contacting gp120 with a CD4-mimetic compound, thereby forming gp120 in the specific conformational state; and generating antibodies to gp120 in the specific conformation state. Relatedly, the disclosure also describes methods of neutralizing HIV-1, comprising contacting HIV-1 with an effective amount of a CD4-mimetic compound, thereby forming HIV-1 having gp120 in a specific conformational state; and contacting the HIV-1 in the specific conformational state with an antibody.
    Type: Application
    Filed: February 10, 2015
    Publication date: December 15, 2016
    Inventors: Joseph SODROSKI, Navid MADANI, Amy M. PRINCIOTTO, Arne SCHON, Judith M. LaLONDE, Ernesto FREIRE, Amos B. SMITH, Richard T. WYATT, Jongwoo PARK, Joel R. COURTER, David M. JONES, Wayne A. HENDRICKSON, Xueling WU, Matthew LE-KHAC, Peter D. KWONG, Young Do KWON, John R. MASCOLA
  • CYCLOALKYL-DIONE DERIVATIVES AND METHODS OF THEIR USE
    Publication number: 20160031805
    Abstract: The present invention is directed to compounds of formula I: wherein A is n is 0, 1, or 2; m is 0 or 1; R1 is H or C1-6alkyl and R2 is H, C1-6alkyl, C1-6alkaryl, aryl, or heteroaryl; and X is O or NH. Tautomers, enantiomers, and diastereomers, as well as pharmaceutically acceptable salt forms, of compounds of formula I are also within the scope of the invention. Methods of preparing and using the compounds of formula I are also described.
    Type: Application
    Filed: April 3, 2014
    Publication date: February 4, 2016
    Inventors: Carlo BALLATORE, Kurt R. BRUNDEN, Virginia M.Y. LEE, Amos B. SMITH, John Q. TROJANOWSKI, Xiaozhao WANG
  • HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES
    Publication number: 20150224105
    Abstract: The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds which are microtubule-stabilizing compounds and their use in the treatment of neurodegenerative disorders, in particular, tauopathies, such as for example, Alzheimer's disease, frontotemporal lobar degeneration, Pick's disease, progressive supranuclear palsy (PSP), and corticobasal degeneration. In addition, the compounds of the invention may be useful for other diseases where tau pathology is a comorbidity or where microtubule function is compromised, for example, schizophrenia, Parkinson's disease (PD), PD with dementia, Lewy body disease with dementia, and amyotrophic lateral sclerosis.
    Type: Application
    Filed: September 19, 2013
    Publication date: August 13, 2015
    Inventors: Carlo Ballatore, Kurt R. Brunden, Adam T. Hoye, Virginia M.Y. Lee, Amos B. Smith, John Q. Trojanowski
  • Thromboxane A2 (TP) receptor antagonists
    Patent number: 8927586
    Abstract: The present invention relates to novel TP receptor antagonists, which optionally cross the blood-brain barrier of a mammal. The invention also provides methods for treating a disorder related to activation of TP receptor utilizing the compounds of the invention.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: January 6, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: John Q. Trojanowski, Virginia M. Y. Lee, Kurt R. Brunden, Amos B. Smith, Donna M. Huym, Carlo Ballatore, Anne-Marie Hogan, Francesco Piscitelli, Sugiyama Shimpei, Xiaozhao Wang
  • Novel Tetrahydronaphalene Antagonists to the Thromboxane A2 (TP) Receptor
    Publication number: 20130190370
    Abstract: The present invention relates to TP receptor antagonists, which have the ability to bind to TP receptor and optionally cross the blood brain barrier. The invention also provides compositions and methods for treating a disorder wherein activation of TP receptor is detrimental.
    Type: Application
    Filed: July 27, 2011
    Publication date: July 25, 2013
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: John Q. Trojanowski, Virginia M.Y. Lee, Kurt R. Brunden, Amos B. Smith, Donna M. Huryn, Carlo Ballatore, Anne-Marie Hogan, Francesco Piscitelli
  • Inhibitors of Human Cathepsin L, Cathepsin B, and Cathepsin S
    Publication number: 20110207726
    Abstract: The present invention is directed to novel protease inhibitors that are specific for cathepsin L, cathepsin B, and cathepsin S. Accordingly, the present invention encompasses compositions and methods for treating and preventing diseases and disorders associated with cathepsin L, cathepsin B, or cathepsin S function or activity.
    Type: Application
    Filed: April 17, 2009
    Publication date: August 25, 2011
    Inventors: Scott L. Diamond, Mary Pat Beavers, Donna Huryn, Michael C. Myers, Amos B. Smith, Parag P. Shah, Zhuqing Liu
  • Chemically Derivatized CD4 and Uses Thereof
    Publication number: 20090247734
    Abstract: This invention provides two soluble polypeptides which comprise a portion of CD4 comprising all HIV gp120-binding epitopes present on intact CD4, wherein the polypeptide has a cysteine substitution at a residue which, in intact CD4, interfaces with HIV gp120. This invention also provides a method for making a derivatized soluble polypeptide and a method for obtaining a structural model useful in the design of an agent for inhibiting CD4 binding to HIV gp120.
    Type: Application
    Filed: December 14, 2006
    Publication date: October 1, 2009
    Inventors: Wayne A. Hendrickson, Hui Xie, Amos B. Smith, Danny Ng
  • New solution and solid phase synthesis of pyrrolinones and polypyrrolinones
    Publication number: 20020133027
    Abstract: The invention provides a new process for the preparation of polypyrrolinones (I) of various sizes which have found to be useful peptidomimetics. One aspect of the invention is a new process utilizing &agr;-amino-&agr;-substituted-valerolactones as synthons. A second aspect of the invention is a process for the synthesis of polypyrrolinones using solid-phase techniques.
    Type: Application
    Filed: April 25, 2001
    Publication date: September 19, 2002
    Inventors: Amos B. Smith, Ralph F. Hirschmann, Hu Liu, Hiroyuki Ikumura
  • Polypyrrolinone based inhibitors of matrix metalloproteases
    Publication number: 20020123635
    Abstract: A compound of the formula 1
    Type: Application
    Filed: October 9, 2001
    Publication date: September 5, 2002
    Inventors: Amos B. Smith, Ralph F. Hirschmann, Thomas Nittoli, Paul Sprengeler
  • Compounds which mimic the chemical and biological properties of discodermolide
    Publication number: 20020103387
    Abstract: Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation.
    Type: Application
    Filed: December 6, 2000
    Publication date: August 1, 2002
    Inventors: Amos B. Smith, Thomas J. Beauchamp, Matthew J. LaMarche