Abstract: A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor.

Abstract: A method cinches a suture. The method provides a cinch having a suture capturing portion configured to capture a suture, a cinch lock coupled with the suture capturing portion, and a cinch anchor having a lumen. The suture capturing portion is extended out of the lumen to capture the suture. The suture is captured by the suture capturing portion. The suture capturing portion is retracted into the lumen of the cinch anchor. The suture is cinched between the cinch lock and the cinch anchor.

Abstract: An endovascular medical device that, when inserted into a vessel having one or more dilations and one or more narrowings in close proximity, redefines the vessel opening (lumen) along the longitudinal axis of the device, separates that lumen from the excess dilated volume within the dilation, and props open the lumen within the narrowing. The device is constructed in a manner to alter the hemodynamics at the interface between the redefined lumen and excess dilated volume, to facilitate the healing process within the dilated vessel. The device is constructed in a manner to provide sufficient radial force to open a narrowed portion of the vessel, to facilitate flow through the vessel. The device is constructed substantially from bioresorbable materials so as to eventually allow for the return of normal vasomechanics and cyclic wall stresses.

Abstract: Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.

Abstract: A surgical apparatus for permitting access to tissue includes an elongated introducer and a surgical port. The introducer includes an outer wall segment defining a longitudinal axis, a longitudinal port passage extending therethrough and a longitudinal slot in communication with the port passage. The introducer is dimensioned for at least partial introduction within an opening in tissue. The surgical port includes a port body mounted to the introducer with one of its leading and trailing ends disposed within the port passage and with the intermediate segment extending through the longitudinal slot and the other of the leading and trailing end external of the elongated introducer. The port body is dimensioned to be advanced within the port passage for deployment through the opening in the tissue and is adapted to transition from a compressed state to a released state.

Abstract: A surgical apparatus for permitting access to tissue includes an elongated introducer and a surgical port. The introducer includes an outer wall segment defining a longitudinal axis, a longitudinal port passage extending therethrough and a longitudinal slot in communication with the port passage. The introducer is dimensioned for at least partial introduction within an opening in tissue. The surgical port includes a port body mounted to the introducer with one of its leading and trailing ends disposed within the port passage and with the intermediate segment extending through the longitudinal slot and the other of the leading and trailing end external of the elongated introducer. The port body is dimensioned to be advanced within the port passage for deployment through the opening in the tissue and is adapted to transition from a compressed state to a released state.

Abstract: An instrument for reconfiguring stomach tissue includes a sealing member that seals a section of a tissue manipulator from contact with bodily fluids. The tissue manipulator includes a first portion that is configured for releasable coupling to an actuating member and a second portion configured to receive an implant to be deployed within the patient. The tissue manipulator also includes a rectangular member and a cavity for receiving a coupler of the actuating member. The tissue manipulator has a first member with tissue penetrating elements and a second member with engaging elements configured to deflect the tissue penetrating elements upon relative movement of the first and second members. The actuating member includes a tissue penetrating element support positioned to limit bending of the tissue manipulator. The instrument includes an actuating mechanism that is configured to move at least one of the first and second members of the tissue manipulator.

Abstract: A medical instrument for engaging tissue includes a flexible shaft, a tissue piercing coil at a distal portion of the shaft, and a tissue stabilizer positioned over the shaft and biased in a distal direction such that as the tissue piercing coil enters tissue, the tissue stabilizer is urged against a surface of the tissue. A medical instrument for reconfiguring tissue includes a flexible shaft defining a lumen housing actuating controls, and a distal actuating assembly with a sealing portion configured to substantially seal the shaft lumen from contact with bodily fluids. A cartridge assembly includes first and second members configured for releasable attachment to a medical instrument, and a holder configured to receive the first and second members and to be released from the first and second members upon action of the first and second members attaching to the medical instrument.

Abstract: Natural orifice transenteric surgical methods and devices for placing a band or other appliance around a hollow bodily organ such as the stomach. In one alternative embodiment, such a band is placed in order to reduce the inner volume of the stomach.

Abstract: Natural orifice transenteric surgical methods and devices for placing a semi-circumferential appliance around a hollow bodily organ such as the stomach. In one alternative embodiment, such an appliance is placed in order to reduce the inner volume of the stomach.

Abstract: Natural orifice transenteric surgical methods and devices for placing a band or other appliance around a hollow bodily organ such as the stomach. In one alternative embodiment, such a band is placed in order to reduce the inner volume of the stomach.

Abstract: Methods and devices are provided for reconfiguring a tissue within a hollow body organ using an entirely endoscopic approach in order to effectively reduce flow of fluid contents into a second hollow body organ in fluid communication with the first.

Abstract: Natural orifice transenteric surgical methods and devices for placing a semi-circumferential appliance around a hollow bodily organ such as the stomach. In one alternative embodiment, such an appliance is placed in order to reduce the inner volume of the stomach.

Abstract: Methods and devices are provided for reconfiguring a tissue within a hollow body organ using an entirely endoscopic approach in order to effectively reduce flow of fluid contents into a second hollow body organ in fluid communication with the first.

Abstract: Methods and devices are provided for reconfiguring a tissue within a hollow body organ using an entirely endoscopic approach in order to effectively reduce flow of fluid contents into a second hollow body organ in fluid communication with the first.

Abstract: Methods and devices are provided for reconfiguring a tissue within a hollow body organ using an entirely endoscopic approach in order to effectively reduce flow of fluid contents into a second hollow body organ in fluid communication with the first.

Abstract: Natural orifice transenteric surgical methods and devices for placing a semi-circumferential appliance around a hollow bodily organ such as the stomach. In one alternative embodiment, such an appliance is placed in order to reduce the inner volume of the stomach.

Abstract: Natural orifice transenteric surgical methods and devices for placing a band or other appliance around a hollow bodily organ such as the stomach. In one alternative embodiment, such a band is placed in order to reduce the inner volume of the stomach.

Abstract: An apparatus includes an elongated member configured for transoral placement into a stomach, and a distal end effector including first and second members configured to engage stomach tissue, e.g., tissue beyond the esophageal junction. The first and second members are movable relatively toward one another generally in a first plane, and the distal end effector is movable relative to the elongated member in a second plane generally transverse to the first plane. A third member of the distal end effector is configured to engage stomach tissue. The third member is movable in a distal direction relative to the first and second members. A tissue securement member of the apparatus is coupled to at least one of the first and second members for securing together tissue engaged thereby.

Abstract: Methods and devices are provided for reconfiguring a tissue within a hollow body organ using an entirely endoscopic approach in order to effectively reduce flow of fluid contents into a second hollow body organ in fluid communication with the first.