Patents by Inventor Amotz Nechushtan

Amotz Nechushtan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7573031
    Abstract: A method of visualizing a sample in a wet environment including introducing a sample into a specimen enclosure in a wet environment and scanning the sample in the specimen enclosure in a scanning electron microscope, thereby visualizing the sample.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: August 11, 2009
    Assignee: Quantomix Ltd.
    Inventors: Vered Behar, Amotz Nechushtan, Yossef Kliger, Opher Gileadi, David Sprinzak, Ory Zik, Yiftuh Karni
  • Publication number: 20090181894
    Abstract: The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin releasing hormone homologues and the cell killing moieties consist of Pseudomonas Exotoxin A. The present invention further relates to pharmaceutical compositions containing as an active ingredient these neoplastic cells targeted chimeric toxins and to a method for the production of these chimeric toxins. The said invention also relates to a method for cancer therapy, treating malignant carcinoma cells and benign hyperplasia including uterine leiomyoma cells, extrauterine endometrial island cells, benign hyperplasia of prostate and breast and pituitary tumor adenoma cells, by the use of the above-mentioned chimeric toxins.
    Type: Application
    Filed: March 13, 2009
    Publication date: July 16, 2009
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shai Yarkoni, Amotz Nechushtan, Haya Lorberboum-Galski, Irina Marianovsky
  • Publication number: 20070210253
    Abstract: A method of visualizing a sample in a wet environment including introducing a sample into a specimen enclosure in a wet environment and scanning the sample in the specimen enclosure in a scanning electron microscope, thereby visualizing the sample.
    Type: Application
    Filed: May 11, 2007
    Publication date: September 13, 2007
    Inventors: Vered Behar, Amotz Nechushtan, Yossef Kliger, Opher Gileadi, David Sprinzak, Ory Zik, Yiftuh Karni
  • Patent number: 7230242
    Abstract: A method of visualizing a sample in a wet environment including introducing a sample into a specimen enclosure in a wet environment and scanning the sample in the specimen enclosure in a scanning electron microscope, thereby visualizing the sample.
    Type: Grant
    Filed: June 1, 2003
    Date of Patent: June 12, 2007
    Assignee: Quantomix Ltd
    Inventors: Vered Behar, Amotz Nechushtan, Yossef Kliger, Opher Gileadi, David Sprinzak, Ory Zik, Yiftah Karni
  • Publication number: 20050256049
    Abstract: The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin releasing hormone homologues and the cell killing moieties consist of Pseudomonas Exotoxin A. The present invention further relates to pharmaceutical compositions containing as an active ingredient these neoplastic cells targeted chimeric toxins and to a method for the production of these chimeric toxins. The said invention also relates to a method for cancer therapy, treating malignant carcinoma cells and benign hyperplasia including uterine leiomyoma cells, extrauterine endometrial island cells, benign hyperplasia of prostate and breast and pituitary tumor adenoma cells, by the use of the above-mentioned chimeric toxins.
    Type: Application
    Filed: June 8, 2005
    Publication date: November 17, 2005
    Applicant: Yissum Res. Dev. Co. of the Hebrew U of Jerusalem
    Inventors: Shai Yarkoni, Amotz Nechushtan, Haya Lorberboum-Galski, Irina Marainovsky
  • Patent number: 6933271
    Abstract: The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin releasing hormone homologues and the cell killing moieties consist of Pseudomonas Exotoxin A. The present invention further relates to pharmaceutical compositions containing as an active ingredient these neoplastic cells targeted chimeric toxins and to a method for the production of these chimeric toxins. The said invention also relates to a method for cancer therapy, treating malignant carcinoma cells and benign hyperplasia including uterine lyomyoma cells, extra uterian endometrial island cells, benign hyperplasia of prostate and breast and pituitary tumor adenoma cells, by the use of the above-mentioned chimeric toxins.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: August 23, 2005
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Shai Yarkoni, Amotz Nechushtan, Haya Lorberboum-Galski, Irina Marianovsky
  • Publication number: 20050173632
    Abstract: A method of visualizing a sample in a wet environment including introducing a sample into a specimen enclosure in a wet environment and scanning the sample in the specimen enclosure in a scanning electron microscope, thereby visualizing the sample.
    Type: Application
    Filed: June 1, 2003
    Publication date: August 11, 2005
    Inventors: Vered Behar, Amotz Nechushtan, Yossef Kliger, Opher Gileadi
  • Publication number: 20020028914
    Abstract: The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin releasing hormone homologues and the cell killing moieties consist of Pseudomonas Exotoxin A. The present invention further relates to pharmaceutical compositions containing as an active ingredient these neoplastic cells targeted chimeric toxins and to a method for the production of these chimeric toxins. The said invention also relates to a method for cancer therapy, treating malignant carcinoma cells and benign hyperplasia including uterine lyomyoma cells, extra uterian endometrial island cells, benign hyperplasia of prostate and breast and pituitary tumor adenoma cells, by the use of the above-mentioned chimeric toxins.
    Type: Application
    Filed: March 1, 1999
    Publication date: March 7, 2002
    Inventors: SHAI YARKONI, AMOTZ NECHUSHTAN, HAYA LORBERBOUM-GALSKI, IRINA MARIANOVSKY
  • Patent number: 6140066
    Abstract: The present invention relates to methods for cancer diagnosis using a chimeric toxin. In particular, the invention relates to the use of a chimeric toxin composed of gonadotropin releasing hormone (GnRH) and Pseudomonas exotoxin A (PE) to detect a tumor-associated epitope expressed by human adenocarcinomas. Mutated GnRH-PE molecules that bind but do not kill tumor cells are exemplified.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: October 31, 2000
    Inventors: Haya Lorberboum-Galski, Shai Yarkoni, Ahmi Ben-Yehudah, Irina Marianovsky, Amotz Nechushtan