Patents by Inventor Amr ABDEEN

Amr ABDEEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanocapsule delivery system for ribonucleoproteins
    Patent number: 11013695
    Abstract: Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: May 25, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Shaoqin Gong, Amr Abdeen, Krishanu Saha, Guojun Chen, Yuyuan Wang, Ruosen Xie
  • NANOCAPSULE DELIVERY SYSTEM FOR RIBONUCLEOPROTEINS
    Publication number: 20190099381
    Abstract: Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.
    Type: Application
    Filed: August 27, 2018
    Publication date: April 4, 2019
    Inventors: Shaoqin GONG, Amr ABDEEN, Krishanu SAHA, Ghojun CHEN, Yuyuan WANG, Ruosen XIE