Abstract: An arthrodesis nail and nail adapter system having multiple coupling positions includes a bent arthrodesis nail and a nail adapter. The nail has multiple evenly spaced notches. The nail adapter has multiple evenly spaced protrusions corresponding to the notches. An arthrodesis nail adapter and target arm system having multiple coupling positions includes a nail adapter and a target arm. The nail adapter has a predetermined coupling orientation with a bent arthrodesis nail. The target arm has multiple coupling positions with the nail adapter. The arthrodesis nail and nail adapter system allows rotation of the bent nail for reduction of ankle deformity.

Abstract: A monitoring device includes an input port attachable for fluid communication with a catheter, the catheter for insertion in a body of a user, for receiving fluid from the body of the user, an output port, generally parallel to the input port, in fluid communication with a fluid reservoir, a fluid channel defining fluid communication between the input port and the output port, and a biosensor for continuously measuring bio-signal data of the fluid in the fluid channel, the biosensor including an electrode pair. The biosensor is in communication with a computing device for determining a condition of the user based at least in part on the bio-signal data.

Abstract: The present invention includes a tibio-talar device for providing stabilizing support between a tibia and a talus including: a bone nail adapted to traverse the tibia and the talus, wherein the bone nail is curved such that it traverses the tibia and enters the talus at an angle, wherein the bone nail is angled from lateral to medial, wherein the bone nail is configured to provide for intra medullary fusion of the ankle without obstructing the subtalar joint, wherein the bone nail has openings are positioned along the length of the bone nail, and wherein the screw engages the bone nail to lock its rotation in relation to the tibia and talus and optionally for compression of two or more bones selected from tibia to talus, fibula to tibia, or fibula to talus,

Abstract: An arthrodesis nail and nail adapter system having multiple coupling positions includes a bent arthrodesis nail and a nail adapter. The nail has multiple evenly spaced notches. The nail adapter has multiple evenly spaced protrusions corresponding to the notches. An arthrodesis nail adapter and target arm system having multiple coupling positions includes a nail adapter and a target arm. The nail adapter has a predetermined coupling orientation with a bent arthrodesis nail. The target arm has multiple coupling positions with the nail adapter. The arthrodesis nail and nail adapter system allows rotation of the bent nail for reduction of ankle deformity.

Abstract: Detecting postoperative complications in a patient uses a substrate made of biocompatible or biodegradable material. An adhesive layer adheres the substrate to patient tissue, surgical tool, or medical device. A biosensor at the substrate detects or measures an analyte in the patient's body. The biosensor may be on the surface of the substrate or within a microchannel in the substrate. A separation or isolation structure may be provided to separate or isolate the analyte from other analytes prior to the biosensor. A microcontroller is disposed on the substrate and connected to the biosensor and to a wireless communications interface also disposed on the substrate. The microcontroller measures a signal from the biosensor and may perform an analysis on the measured signal. Measured data or data resulting from the analysis is transmitted through the wireless communications interface to a transdermal patch or other remote device for storage and display.

Abstract: The present invention includes a tibio-talar device for providing stabilizing support between a tibia and a talus including: a bone nail adapted to traverse the tibia and the talus, wherein the bone nail is curved such that it traverses the tibia and enters the talus at an angle, wherein the bone nail is angled from lateral to medial, wherein the bone nail is configured to provide for intra medullary fusion of the ankle without obstructing the subtalar joint, wherein the bone nail has openings are positioned along the length of the bone nail, and wherein the screw engages the bone nail to lock its rotation in relation to the tibia and talus and optionally for compression of two or more bones selected from tibia to talus, fibula to tibia, or fibula to talus,

Abstract: An extramedullary bone lengthener and use thereof that is an internal device that does not require nailing. The invention includes a telescoping plate that attaches to the upper and lower portions of the bone via screws; a small motor affixed on or within the plate. This motor, controlled remotely, will controllably lengthen the plate, thus lengthening the bone. The bone will be cut (osteotomy) then the plate will be applied to both ends and fixed to each end with screws. The motor will be controlled from outside by a remote control which will allow the plate to expand causing lengthening of the attached bone.

Abstract: The present invention includes a tibio-talar device and a method for providing stabilizing support between a tibia and a talus comprising: a bone nail adapted to traverse the talus and the tibia, wherein the bone nail is curved such that it traverses the talus and enters the tibia at an angle, wherein the nail is angled from side to side, wherein the bone nail is configured to provide for intra medullary fusion of the ankle without obstructing the subtalar joint. The nail is introduced from talus and curves to pass to the tibia fusing the ankle joint.

Abstract: Detecting postoperative complications in a patient uses a substrate made of biocompatible or biodegradable material. An adhesive layer adheres the substrate to patient tissue, surgical tool, or medical device. A biosensor at the substrate detects or measures an analyte in the patient's body. The biosensor may be on the surface of the substrate or within a microchannel in the substrate. A separation or isolation structure may be provided to separate or isolate the analyte from other analytes prior to the biosensor. A microcontroller is disposed on the substrate and connected to the biosensor and to a wireless communications interface also disposed on the substrate. The microcontroller measures a signal from the biosensor and may perform an analysis on the measured signal. Measured data or data resulting from the analysis is transmitted through the wireless communications interface to a transdermal patch or other remote device for storage and display.

Abstract: An extramedullary bone lengthener and use thereof that is an internal device that does not require nailing. The invention includes a telescoping plate that attaches to the upper and lower portions of the bone via screws; a small motor affixed on or within the plate. This motor, controlled remotely, will controllably lengthen the plate, thus lengthening the bone. The bone will be cut (osteotomy) then the plate will be applied to both ends and fixed to each end with screws. The motor will be controlled from outside by a remote control which will allow the plate to expand causing lengthening of the attached bone.

Abstract: A treatment method, system, and compound comprise directly targets osteomyelitis-infected bone tissue with one or more surface-modified liposomes. The surface-modified liposome(s) includes an alendronate targeting moiety utilized to modify the surface of the liposome. Alendronate targets hydroxyapatite in bone tissue, wherein the surface-modified liposome further comprises encapsulated vancomycin that directly targets the hydroxyapatite in the infected bone tissue and prevents bone implant related infection.