Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution substantially free of organic solvent, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.

Abstract: The simulation system (100) and method for simulating virtual human-body dissection, as compared to prior-arts, provides an accurate representation of human anatomical structures, allowing users to perform virtual dissections and gain tactile insights into the texture and feel of various organs, tissues and structures. Simulation system (100) includes a computing bed (10) with an interactive-display screen (20), a haptic device (30), a graphic rendering device (40), a control unit (50) and processing unit (51). The interactive-display screen (20) enables selection of a region-selection module (20a), a tool-selection module (20b), an anatomical planes and positions module (20c) and a training module (20d) which are operated and viewed by the haptic device (30), a graphic rendering device (40) to perform virtual dissections and gain tactile insights into the texture and feel.

Abstract: The system (100) and method for simulation and understanding embryology, as compared to prior-arts, is capable to help understand embryology by simulation. System (100) and method includes a processing system (10) that has an interactive module (20) which receives selection of a user from a general embryology module (20a), a systemic embryology module (20b), a genetics module (20c), and a stem cells module (20d). The system (100) and method also includes a text module (30) to display text, an audio-video module (40) to play a three-dimensional simulation module (50) to allow simulation, a fetal surgery and intervention simulation module (60) and a comparative module (70) to allow comparison of fetal anatomical structures and physiology at different developmental stages of age to adults.

Abstract: A system for bulk dispensing an expandable sealant for use in an electrical fitting configured to be used in a hazardous or harsh environment. The system includes a container having a first chamber for holding a first component and a second chamber for holding a second component. An injector is configured to receive the container. The injector includes a first plunger and a second plunger wherein the first plunger aligns with the first chamber and the second chamber aligns with the second plunger when the container is positioned in the injector. A nozzle is configured to engage a distal end of the container. The nozzle is positioned to fluidly communicate with the first chamber and the second chamber when attached to the container. The nozzle has an internal labyrinth passage configured to fluidly connect to the first chamber and the second chamber.

Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution substantially free of organic solvent, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.

Abstract: The present invention relates to a method of preparation of Glycolipid carboxylic acids of Formula I by selective hydrolysis of corresponding esters by enzymes. The method provides preparation of compounds of Formula I in high yield by an environmentally benign, robust, economical, simple and convenient method.

Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution substantially free of organic solvent, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.

Abstract: A nasal spray formulation and a method of using a locally acting sodium channel blocker to treat pain is disclosed, wherein the nasal spray formulation comprises from about 5% to about 30% w/v of a locally active sodium channel blocker, from about 0.25% to about 5% w/v of a buffering agent, and from about 5 to about 99% w/v of a pharmaceutically acceptable carrier for nasal administration. The nasal spray formulation is preferably contained in a mechanical multi-dose pump which sprays a unit dose of the nasal spray formulation with a wide plume and small droplet size, such that the unit dose is administered by actuating the mechanical multi-dose spray pump device and spraying a volume of the nasal spray formulation into each nostril of a human subject. Preferably, the nasal spray formulation does not include a preservative.

Abstract: A method of providing an IV nimodipine infusion regimen using a solubilized nimodipine solution suitable for IV administration is disclosed. The IV nimodipine infusion regimen provides a constant infusion rate over the (entire) 24 hour period supplemented with higher infusions of nimodipine at set intervals to duplicate the 24 hour AUC and Cmax of an oral nimodipine dose.

Abstract: A method for determining a capacitance value of a capacitor is provided. The method includes receiving a current signal flowing through the capacitor and receiving a voltage signal applied across the capacitor. The received voltage signal and the received current signal are filtered with a low pass filter. The filtered voltage signal and the filtered current signal are then discretized. The discretized voltage signal and the discretized current signal are transformed into a frequency domain. The capacitance value of the capacitor is determined from the transformed voltage signal and the transformed current signal.

Abstract: The present disclosure relates to wireless electrical discontinuity detection methods and systems, the systems including at least one conduit having an outer layer including an electrically conductive material, an electrical signal generator electrically coupled to the at least one conduit, the electrical signal generator being configured to deliver electrical signals to the outer layer of the at least one conduit, and a detector device in electrical communication with the electrical signal generator and configured to detect an electrical signal from the electrically conductive outer layer, the detector device being configured to identify at least one of electrical connection and ground discontinuity in the at least one conduit based on the detected electrical signal, wherein the detector device is in wireless communication with a control station.

Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.

Abstract: A polymeric bio-adhesive film forming topical spray formulation providing a modified, pulsatile (e.g., biphasic) release of the active agent(s) once the solvent evaporates and the film sets, e.g., on human skin is disclosed. In certain embodiments, the active agent is bupivacaine hydrochloride.

Abstract: A polymeric bio-adhesive film forming topical spray formulation providing a modified, pulsatile (e.g., biphasic) release of the active agent(s) once the solvent evaporates and the film sets, e.g., on human skin is disclosed. In certain embodiments, the active agent is bupivacaine hydrochloride.

Abstract: A stable oral spray formulation comprising a glucocorticoid together with other excipients is disclosed. In preferred embodiments, the spray formulation is used to treat neurological disorders such as ataxia by being sprayed in an effective dose into the mouth of a patient.

Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution substantially free of organic solvent, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.

Abstract: A control system includes: a controller configured to: access an estimated torque and estimated speed of a motor mechanically coupled to an impeller of a centrifugal machine; access at least one set of pre-determined performance data values associated with a known speed of the impeller, where each set of pre-determined performance data values includes: a plurality of flowrate values and a plurality of performance metric values; determine an operating point of the centrifugal machine based on the estimated torque, the estimated speed, and the at least one set of pre-determined performance data values; compare the determined operating point to a best efficiency point (BEP) associated with the centrifugal machine; and determine whether to change the speed of the motor based on the comparison.

Abstract: A reforming reactor and process of using same in which a flow distributor distributes the process gas circumferentially to the reactive zone. Feed is injected into the reactor into a non-reactive zone. The non-reactive zone has two portions, a first portion receiving the feed, and a second portion receiving a purge gas. The purge gas will flow from the second portion to the first portion to prevent flow of the feed from the first portion to the second portion. The combined gas may be passed to a reaction zone for catalytic reforming. The first portion and the second portion may be separated by a flow distributor having two horizontal portions connected to opposite ends of a vertical portion.

Abstract: A reforming reactor and process of using same in which a flow distributor distributes the process gas circumferentially to the reactive zone. Feed is injected into the reactor into a non-reactive zone. The non-reactive zone has two portions, a first portion receiving the feed, and a second portion receiving a purge gas. The purge gas will flow from the second portion to the first portion to prevent flow of the feed from the first portion to the second portion. The combined gas may be passed to a reaction zone for catalytic reforming. The first portion and the second portion may be separated by a flow distributor having two horizontal portions connected to opposite ends of a vertical portion.

Abstract: A nimodipine injection concentrate and diluted formulation comprises nimodipine (base or salt), an effective amount of a hydrophilic surfactant, and a pharmaceutically acceptable carrier for injection which is an aqueous solution, an organic solvent, an oil, or a cyclodextrin, such that the nimodipine is substantially contained in a concentrated injection solution, suspension, emulsion or complex as a micelle or a colloidal particle or an inclusion complex and the formulation is stable and clear. In certain embodiments, the hydrophilic surfactant is polysorbate 80.