Patents by Inventor Amrita K. CHEEMA
Amrita K. CHEEMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11808774Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: January 25, 2021Date of Patent: November 7, 2023Assignees: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Patent number: 11280797Abstract: The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.Type: GrantFiled: February 2, 2018Date of Patent: March 22, 2022Assignees: Georgetown University, University of RochesterInventors: Mark E. Mapstone, Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema
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Publication number: 20220065863Abstract: Methods of treating with radiation therapy a subject having cancer, in which the method comprises administering radiation therapy to the subject. The subject does not have an increased risk of having an adverse reaction to radiation therapy. The subject has an increased risk of an adverse reaction to radiation therapy when the subject's level of each component in a component profile from a sample of the subject is altered as compared to the normal level of each component. The component profile may comprise a metabolite panel of geranyl pyrophosphate, glucose-1-phosphate, and 3-hydroxy-3-methylglutaryl-CoA; a lipid panel of LPA 18:0, LPA 16:0, LPC 20:2, CER 24:0, and LPI 16:1; or a combination of these panels. The component profile may also comprise a metabolite panel of metanephrine, tryptophan, xanthurenic acid, and pantothenate; a lipid panel of LPA 18:0, DAG 16:0/18:0, LPA 16:0, and DAG 18:1/18:1; or a combination of these panels.Type: ApplicationFiled: September 15, 2021Publication date: March 3, 2022Applicant: Georgetown UniversityInventors: Anatoly Dritschilo, Amrita K. Cheema, Scott Grindrod, Xiaogang Zhong
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Publication number: 20210285973Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's meta-bolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: January 25, 2021Publication date: September 16, 2021Applicants: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Patent number: 10900980Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: May 18, 2016Date of Patent: January 26, 2021Assignees: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Patent number: 10900977Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: October 17, 2016Date of Patent: January 26, 2021Assignees: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone, Xiaogang Zhong
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Patent number: 10890589Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: May 27, 2015Date of Patent: January 12, 2021Assignees: Georgetown University, University of RochesterInventors: Massimo S. Fiandaca, Mark E. Mapstone, Howard J. Federoff, Xiaogang Zhong, Amrita K. Cheema
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Publication number: 20200239959Abstract: Methods of determining if a subject has an increased risk of poor recovery after suffering a stroke and methods of treating a subject recovering from a stroke. The methods comprise analyzing at least one plasma sample taken from the subject to assess a microRNA (miRNA) profile of the subject and comparing the subject's miRNA profile with a normal miRNA profile, to determine if the subject's miRNA profile is altered compared to a normal miRNA profile. An alteration of the subject's miRNA profile is indicative that the subject has an increased risk of poor recovery after suffering a stroke.Type: ApplicationFiled: January 24, 2020Publication date: July 30, 2020Applicant: Georgetown UniversityInventors: Matthew A. Edwardson, Xiaogang Zhong, Massimo S. Fiandaca, Howard J. Federoff, Amrita K. Cheema, Alexander W. Dromerick
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Patent number: 10578629Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: GrantFiled: April 21, 2016Date of Patent: March 3, 2020Assignees: GEORGETOWN UNIVERSITY, UNIVERSITY OF ROCHESTERInventors: Howard J. Federoff, Mark E. Mapstone, Amrita K. Cheema, Massimo S. Fiandaca
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Publication number: 20200011881Abstract: The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.Type: ApplicationFiled: February 2, 2018Publication date: January 9, 2020Applicants: Georgetown University, University of RochesterInventors: Mark E. Mapstone, Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema
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Publication number: 20180306811Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: October 17, 2016Publication date: October 25, 2018Applicants: Georgetown University, University of RochesterInventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone, Xiaogang Zhong
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Publication number: 20180149665Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: May 18, 2016Publication date: May 31, 2018Inventors: Howard J. Federoff, Massimo S. Fiandaca, Amrita K. Cheema, Mark E. Mapstone
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Publication number: 20170192018Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: May 27, 2015Publication date: July 6, 2017Inventors: Massimo S. FIANDACA, Mark E. MAPSTONE, Howard J. FEDEROFF, Xiaogang ZHONG, Amrita K. CHEEMA
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Publication number: 20170052204Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and also analyzing the gene expression profile from leukocytes and comparing the value of the subject's biomarker profile (lipidomic profile plus gene expression profile) with the value of a normal biomarker profile. A change in the value of the subject's biomarker profile, including a change in the subject's biomarker profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: April 30, 2015Publication date: February 23, 2017Inventors: Howard J. Federoff, Mark E. Mapstone, Amrita K. Cheema, Massimo S. Fiandaca
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Publication number: 20160238622Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.Type: ApplicationFiled: April 21, 2016Publication date: August 18, 2016Inventors: Howard J. FEDEROFF, Mark E. MAPSTONE, Amrita K. CHEEMA, Massimo S. FIANDACA