Patents by Inventor AMY CASTILLO
AMY CASTILLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230055565Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: ApplicationFiled: September 26, 2022Publication date: February 23, 2023Applicant: Life Technologies CorporationInventors: Stephen P. Hendricks, Michael Phelan, Marian Peris, Cheng-Yao Chen, Daniel Mazur, Xinzhan Peng, Amy Castillo
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Patent number: 11453909Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: GrantFiled: September 6, 2018Date of Patent: September 27, 2022Assignee: Life Technologies CorporationInventors: Stephen P. Hendricks, Michael Phelan, Marian Peris, Cheng-Yao Chen, Daniel Mazur, Xinzhan Peng, Amy Castillo
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Publication number: 20210064199Abstract: Examples herein describe systems and methods for providing a graphical user interface (“GUI”) dashboard. Data can be retrieved from multiple sources. The data can be processed, and the processed data can be used to generate a GUI in dashboard format. The dashboard can have multiple GUI elements that allow user interaction. The GUI elements, or portions thereof, can be selected, resulting in the remaining GUI elements changing how data is presented or changing the dashboard to a detailed view. The GUI dashboard can be updated in real time.Type: ApplicationFiled: August 27, 2019Publication date: March 4, 2021Inventors: Amy Castillo, William Arnold, Kathleen Sill, James Miller, Donna Eudaley, Paula Evans, Aimee Grimaldi
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Publication number: 20190062828Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: ApplicationFiled: September 6, 2018Publication date: February 28, 2019Inventors: Stephen P. HENDRICKS, Michael PHELAN, Marian PERIS, Cheng-Yao CHEN, Daniel MAZUR, Xinzhan PENG, Amy CASTILLO
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Patent number: 10093973Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: GrantFiled: June 1, 2016Date of Patent: October 9, 2018Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Stephen P. Hendricks, Michael Phelan, Marian Peris, Cheng-Yao Chen, Daniel Mazur, Xinzhan Peng, Amy Castillo
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Publication number: 20160265045Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: ApplicationFiled: June 1, 2016Publication date: September 15, 2016Inventors: Stephen P. HENDRICKS, Michael PHELAN, Marian PERIS, Cheng-Yao CHEN, Daniel MAZUR, Xinzhan PENG, Amy CASTILLO
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Patent number: 9365839Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: GrantFiled: May 12, 2015Date of Patent: June 14, 2016Assignee: Life Technologies CorporationInventors: Stephen P. Hendricks, Michael Phelan, Marian Peris, Cheng-Yao Chen, Daniel Mazur, Xinzhan Peng, Amy Castillo
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Publication number: 20150247136Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: ApplicationFiled: May 12, 2015Publication date: September 3, 2015Inventors: Stephen P. HENDRICKS, Michael PHELAN, Marian PERIS, Cheng-Yao CHEN, Daniel MAZUR, Xinzhan PENG, Amy CASTILLO
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Publication number: 20120322057Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: ApplicationFiled: July 3, 2012Publication date: December 20, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Stephen P. HENDRICKS, Michael PHELAN, Marian PERIS, Cheng-Yao CHEN, Daniel MAZUR, Xinzhan PENG, Amy CASTILLO
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Publication number: 20110165652Abstract: Compositions, systems and methods of sequencing are disclosed, where the compositions and systems include polymerase enzymes that have been genetically modified to more efficiently incorporate nucleotides including labels having a detectable properties that are released during incorporation, to augment a rate of labeled nucleotide incorporation, to augment a rate of pyrophosphate release, or to augment two or more of these properties and rates. Also disclosed are terminally labeled and dual labeled nucleotides, and click-chemistry based methods of synthesizing the same.Type: ApplicationFiled: January 14, 2009Publication date: July 7, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Susan H. Hardin, Tommie Lloyd Lincecum, JR., Norha Deluge, Hongyi Wang, Yuri Belosludtsev, Kristi Kincaid, Anelia Kraltcheva, Benjamin Stevens, Ming Fa, Amy Bryant, Amy Castillo, Hye Eun Kim, Uma Nagaswamy, Mitsu Sreedhar Reddy, Alok N. Bandekar, Ivan Pan, Andrei Volkov
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Publication number: 20110014612Abstract: Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of making and using such compositions. In some embodiments, the compositions exhibit altered properties that can enhance their utility in a variety of biological applications. Such altered properties, can include, for example, altered nucleotide binding affinities, altered nucleotide incorporation kinetics, altered photostability and/or altered nanoparticle tolerance, as well as a range of other properties as disclosed herein.Type: ApplicationFiled: March 26, 2010Publication date: January 20, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: STEPHEN P. HENDRICKS, MICHAEL PHELAN, MARIAN PERIS, CHENG-YAO CHEN, DANIEL MAZUR, XINZHAN PENG, AMY CASTILLO