Abstract: A blood glucose monitoring system with a graphical user interface (GUI) and methods of controlling the system and performing episodic blood glucose testing using the GUI are disclosed. The system can comprise the GUI, an output display for displaying the GUI, user interfaces, a memory and a processor. An episodic blood glucose testing protocol can be programmed into the processor using the user interfaces and automatically saved into memory. A user can be alerted to test blood glucose levels based on the inputted testing protocol by the display of an alert icon on the GUI. Blood glucose level results can be received, displayed on the GUI along with a range icon and automatically saved into memory. Statistics of the saved blood glucose results can be calculated by the processor and saved into memory. The statistics can be retrieved for display on the GUI when prompted by the user.