Patents by Inventor Amy E. Rabideau

Amy E. Rabideau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20190247417
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by improved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: September 14, 2017
    Publication date: August 15, 2019
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • HIGH PURITY RNA COMPOSITIONS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20180363019
    Abstract: The invention relates to improved RNA compositions for use in therapeutic applications. The RNA compositions are particularly suited for use in human therapeutic application (e.g., in RNA therapeutics). The RNA compositions are made by inproved processes, in particular, improved in vitro-transcription (IVT) processes. The invention also relates to methods for producing and purifying RNA (e.g, therapeutic RNAs), as well as methods for using the RNA compositions and therapeutic applications thereof.
    Type: Application
    Filed: June 6, 2018
    Publication date: December 20, 2018
    Applicant: ModernaTX, Inc.
    Inventors: Stephen Hoge, William Issa, Edward J. Miracco, Jennifer Nelson, Amy E. Rabideau, Gabor Butora
  • Protein retrosplicing enabled by a double ligation reaction
    Patent number: 9731029
    Abstract: Proteins containing a C-terminal thioester are important intermediates in semi-synthesis. Currently there is one main method for the synthesis of protein thioesters that relies upon the use of engineered inteins. The invention involves, in some aspects a method, utilizing Sortase A, for preparation of recombinant proteins containing a C-terminal ?thioester. This new method for double ligatation is useful for synthesizing new or naturally occurring molecules such as a protein thioester.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: August 15, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Bradley L. Pentelute, Xiaoli Liao, Amy E. Rabideau, Jingjing Ling, Rocco L. Policarpo
  • TRANSLOCATION OF NON-NATURAL CHEMICAL ENTITIES THROUGH ANTHRAX PROTECTIVE ANTIGEN PORE
    Publication number: 20170049906
    Abstract: Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.
    Type: Application
    Filed: November 1, 2016
    Publication date: February 23, 2017
    Applicants: President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Xiaoli Liao, Amy E. Rabideau, Bradley L. Pentelute, Jingjing Ling, Gizem Akçay, John Collier
  • Translocation of non-natural chemical entities through anthrax protective antigen pore
    Patent number: 9498538
    Abstract: Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: November 22, 2016
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Xiaoli Liao, Amy E. Rabideau, Bradley L. Pentelute, Jingjing Ling, Gizem Akçay, John Collier
  • TRANSLOCATION OF NON-NATURAL CHEMICAL ENTITIES THROUGH ANTHRAX PROTECTIVE ANTIGEN PORE
    Publication number: 20150165062
    Abstract: Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.
    Type: Application
    Filed: May 21, 2013
    Publication date: June 18, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: Xiaoli Liao, Amy E. Rabideau, Bradley L. Pentelute, Jingjing Ling, Gizem Akçay
  • PROTEIN RETROSPLICING ENABLED BY A DOUBLE LIGATION REACTION
    Publication number: 20150152134
    Abstract: Proteins containing a C-terminal thioester are important intermediates in semi-synthesis. Currently there is one main method for the synthesis of protein thioesters that relies upon the use of engineered inteins. The invention involves, in some aspects a method, utilizing Sortase A, for preparation of recombinant proteins containing a C-terminal ?thioester. This new method for double ligatation is useful for synthesizing new or naturally occurring molecules such as a protein thioester.
    Type: Application
    Filed: May 21, 2013
    Publication date: June 4, 2015
    Inventors: Bradley L. Pentelute, Xiaoli Liao, Amy E. Rabideau, Jingjing Ling, Rocco L. Policarpo