Abstract: In one aspect, described are biosensors comprising a working electrode layer comprising a dendritic array comprising metallic dendrites having a conductive polymer layer. Systems are described using the disclosed biosensors useful for POC disease diagnosis, including, but not limited to, resource limited areas. Methods are described for making the disclosed biosensors which allow for improved control of dendritic growth using a pillared substrate, rather than a planar one. Also described are methods of using the disclosed biosensors to detect an analyte associated with a particular disease, e.g., an infectious disease. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.