Patents by Inventor Amy Jo Wagers

Amy Jo Wagers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR BACTERIAL DELIVERY OF POLYPEPTIDES
    Publication number: 20190055569
    Abstract: The methods and compositions described herein relate to the delivery of polypeptides to a target cell, e.g. by utilizing engineered non-pathogenic bacteria comprising a type three secretion system (T3SS) and T3SS-compatible substrates. In one aspect, described herein are non-pathogenic microbial cells that have been engineered to express both a functional type three secretion system (T3SS) and at least one polypeptide that is compatible with the T3SS. Due to the wide variety of polypeptides that can be delivered to a target eukaryotic cell using the compositions and systems described herein, a commensurately wide variety of applications is contemplated, e.g. therapeutics and reprogramming.
    Type: Application
    Filed: March 9, 2018
    Publication date: February 21, 2019
    Applicants: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Cammie LESSER, Amy Jo Wagers, Analise Z. Reeves
  • Compositions and methods for bacterial delivery of polypeptides
    Patent number: 9951340
    Abstract: The methods and compositions described herein relate to the delivery of polypeptides to a target cell, e.g. by utilizing engineered non-pathogenic bacteria comprising a type three secretion system (T3SS) and T3SS-compatible substrates. In one aspect, described herein are non-pathogenic microbial cells that have been engineered to express both a functional type three secretion system (T3SS) and at least one polypeptide that is compatible with the T3SS. Due to the wide variety of polypeptides that can be delivered to a target eukaryotic cell using the compositions and systems described herein, a commensurately wide variety of applications is contemplated, e.g. therapeutics and reprogramming.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 24, 2018
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Cammie Lesser, Amy Jo Wagers, Analise Z. Reeves
  • COMPOSITIONS AND METHODS FOR BACTERIAL DELIVERY OF POLYPEPTIDES
    Publication number: 20160046951
    Abstract: The methods and compositions described herein relate to the delivery of polypeptides to a target cell, e.g. by utilizing engineered non-pathogenic bacteria comprising a type three secretion system (T3SS) and T3SS-compatible substrates. In one aspect, described herein are non-pathogenic microbial cells that have been engineered to express both a functional type three secretion system (T3SS) and at least one polypeptide that is compatible with the T3SS. Due to the wide variety of polypeptides that can be delivered to a target eukaryotic cell using the compositions and systems described herein, a commensurately wide variety of applications is contemplated, e.g. therapeutics and reprogramming.
    Type: Application
    Filed: March 6, 2014
    Publication date: February 18, 2016
    Inventors: Cammie LESSER, Amy Jo WAGERS, Analise Z. REEVES
  • Isolation and characterization of muscle regenerating cells
    Patent number: 7749754
    Abstract: Populations enriched for myogenic progenitors are obtained by selection on the basis of expression of specific cell surface markers. The muscle progenitor cells are characterized as being CD45? and CD34+, and may further be characterized as lacking expression of Mac-1 (CD11b) and positive for expression of CXCR4 (CD184) and ?1-integrin (CD29).
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: July 6, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard Irving Sherwood, Amy Jo Wagers, Irving Weissman