Patents by Inventor Amy L. Connolly

Amy L. Connolly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11459619
    Abstract: A method for identifying a predefined target organism includes extracting a nucleic acid from a sample to form an extracted nucleic acid, amplifying the extracted nucleic acid to form a nucleic acid amplicon, tagging the nucleic acid amplicon with a capture probe and a detector partner to form a detector partner-nucleic acid amplicon-capture probe complex, and performing a detection assay on the detector partner-nucleic acid amplicon-capture probe complex to identify whether the predefined target organism is present in the sample.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: October 4, 2022
    Assignee: The Johns Hopkins University
    Inventors: Mekbib Astatke, Amy L. Connolly
  • Publication number: 20200040408
    Abstract: A method for identifying a predefined target organism includes extracting a nucleic acid from a sample to form an extracted nucleic acid, amplifying the extracted nucleic acid to form a nucleic acid amplicon, tagging the nucleic acid amplicon with a capture probe and a detector partner to form a detector partner-nucleic acid amplicon-capture probe complex, and performing a detection assay on the detector partner-nucleic acid amplicon-capture probe complex to identify whether the predefined target organism is present in the sample.
    Type: Application
    Filed: May 6, 2019
    Publication date: February 6, 2020
    Inventors: Mekbib Astatke, Amy L. Connolly
  • Publication number: 20180120330
    Abstract: A method for a pre-symptomatic diagnosis of a viral illness includes obtaining a biological sample with a peripheral blood mononuclear cell from a subject. The method further includes stimulating the biological sample, where the stimulation of the biological sample includes adding to the biological sample a predetermined amount of antigen configured to trigger a T-cell IFN-? response in the biological sample and a predetermined amount of reagent configured to capture the T-cell IFN-? response. The method may even further include comparing the level of the T-cell IFN-? response detected in the biological sample to a control sample level, the control sample level including a control sample T-cell IFN-? response level detected in a control sample of the subject, where if the level of the T-cell IFN-? response in the biological sample is at a predetermined amount greater than the control sample level, the subject is diagnosed with the viral illness.
    Type: Application
    Filed: August 22, 2017
    Publication date: May 3, 2018
    Inventors: Mekbib Astatke, Amy L. Connolly, Allyson M. Bissing-Gibson
  • Publication number: 20170226593
    Abstract: A method for identifying a target organism includes extracting a nucleic acid from a sample to form an extracted nucleic acid, amplifying the extracted nucleic acid to form a nucleic acid amplicon, tagging the nucleic acid amplicon with a capture probe and a detector probe to form a detector probe-nucleic acid amplicon-capture probe complex, and performing a detection assay on the detector probe-nucleic acid amplicon-capture probe complex to identify whether the target organism is present in the sample.
    Type: Application
    Filed: February 8, 2016
    Publication date: August 10, 2017
    Inventors: Mekbib Astatke, Amy L. Connolly