Abstract: A surgical apparatus comprises a body, an ultrasonic transducer, a shaft, and an end effector. The ultrasonic transducer is operable to convert electrical power into ultrasonic vibrations. The body comprises a pivotal trigger. The shaft couples the end effector and the body together. The end effector comprises a clamp arm and an ultrasonic blade in acoustic communication with the ultrasonic transducer. The ultrasonic blade is operable to deliver ultrasonic vibrations to tissue. Pivotal movement of the trigger causes movement of the clamp arm. The trigger includes a compliant feature configured to limit the amount of force delivered to tissue by the clamp arm. The flexible feature may comprise a flexible band, living hinge, a series of living hinges, or a flexible tab.

Abstract: A system may include at least one sensor and at least one processor configured to, based at least on stress data, at least one of (i) identify at least one occurrence of at least one potential for at least one human error or (ii) predict the at least one occurrence of the at least one potential for the at least one human error; and upon an identification and/or a prediction, output at least one instruction to cause (a) a modification to a human machine interface (HMI) device that interfaces with a user, (b) a modification to an amount of automated digital assistance provided to the user, (c) a modification of content presented to the user, (d) an alert to the user, and/or (e) a presentation of a solution to increase comprehension by the user.

Abstract: A surgical apparatus comprises a body, an ultrasonic transducer, a shaft, an acoustic waveguide, an articulation section, an end effector, and an articulation drive assembly. The ultrasonic transducer is operable to convert electrical power into ultrasonic vibrations. The shaft couples the end effector and the body together. The acoustic waveguide is coupled with the transducer. The articulation section includes a collar that is located distal to a nodal portion of the waveguide and is operable to deflect the end effector away from the longitudinal axis. The end effector comprises an ultrasonic blade in acoustic communication with the ultrasonic transducer. The articulation drive assembly is operable to drive articulation of the articulation section. The articulation drive assembly comprises at least one translating articulation driver coupled with the collar. The ultrasonic blade is operable to deliver ultrasonic vibrations to tissue even when the articulation section is in an articulated state.

Abstract: A system and method select an image from multiple images taken at nearly the same time, based on blur, contour value or an estimate of either or both of these derived from the accelerometer of the device that captured the images, and then uploads the selected image.

Abstract: The present disclosure relates to fluidic systems and devices for processing, extracting, or purifying one or more analytes. These systems and devices can be used for processing samples and extracting nucleic acids, for example by isotachophoresis. In particular, the systems and related methods can allow for extraction of nucleic acids, including non-crosslinked nucleic acids, from samples such as tissue or cells. The systems and devices can also be used for multiplex parallel sample processing.

Abstract: The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.

Abstract: Aspects of the present invention relate to the use of chemokine receptors such as e.g., CCR4 and CCR6, as homing agents. The chemokine receptor(s) is/are expressed by cells containing synthetic chromosomes. The chemokine receptor(s) is/are under controllable expression from a synthetic chromosome and can be used to control an immune response so as to treat or inhibit a disease such as cancer. The control is provided by inducing leukocyte trafficking to sites of disease. If more than one chemokine receptor is expressed, the levels can be individually controlled so that the desired cellular trafficking pattern can be obtained.

Abstract: Aspects of the present invention relate to synthetic chromosomes that may be incorporated into leukocytes, wherein the synthetic chromosomes comprise nucleic acid sequences encoding multiple Chimeric Antigen Receptors (CARs). Such manipulated leukocytes can be used in medicine, notably in the treatment of a cancer such as in the treatment of cancer having solid tumors. The leukocytes may be lymphocytes, including tumor-infiltrating lymphocytes. T cells. NK cells or B cells. In a preferred aspect, the leucocytes are syngeneic and T cells.

Abstract: A surgical apparatus comprises a body, an ultrasonic transducer, a shaft, and an end effector. The ultrasonic transducer is operable to convert electrical power into ultrasonic vibrations. The body comprises a pivotal trigger. The shaft couples the end effector and the body together. The end effector comprises a clamp arm and an ultrasonic blade in acoustic communication with the ultrasonic transducer. The ultrasonic blade is operable to deliver ultrasonic vibrations to tissue. Pivotal movement of the trigger causes movement of the clamp arm. The trigger includes a compliant feature configured to limit the amount of force delivered to tissue by the clamp arm. The flexible feature may comprise a flexible band, living hinge, a series of living hinges, or a flexible tab.

Abstract: A surgical instrument includes an ultrasonic transducer, an ultrasonic transmission waveguide extending from the ultrasonic transducer, and an ultrasonic blade acoustically coupled to the ultrasonic transmission waveguide. The ultrasonic blade includes a base and a curved body extending distally from the base. The curved body includes a tissue-treating surface extending on a first side of the curved body and a curved edge extending on a second side of the curved body opposite the first side. The curved edge has a proximal end and a distal end, wherein the proximal end is offset from the distal end in a first direction, wherein the proximal end is offset from the distal end in a second direction, and wherein the first direction is perpendicular to the second direction.

Abstract: A set of tools for installation of a stem implant into a bone comprises a stem-shaped priming tool 1 having a distal tip 32 and a plurality of cutting teeth 31 along a length thereof and a plurality of stem-shaped broaches 2, 3, 4, 5, 6 of different size. Each of the broaches have a distal tip and a plurality of cutting teeth along a length thereof. The priming tool 1 is shorter than, has more cutting teeth 31 per unit length, and has a sharper distal tip 32 than the smallest broach.

Abstract: A hemi-arthroplasty bone joint implant has a first part (120) with a stem (111) tor intramedullary implanting into a metacarpal, and a second part (110) to engage the trapezium is a translational manner, a hemi-arthroplasty articulating coupling (121). This allows multi-axial motion with translational movement of the second part over the trapezium and rotation of the first part (110) about the articulating coupling (121, 103). There is also a converter to convert the implant to a toral arthroplasty implant in situ during revision surgery. The second part (110) and the hemi-arthroplasty coupling (100, 123, 121) are removable in situ during revision surgery. The first part (120) has an engagement threaded socket (117) for, after removal of the second part and the hemi-arthroplasty coupling, engaging the replacement coupling (200) and allowing mutual articulation of the first (120) and replacement parts (220). This forms a total arthroplasty joint implant.

Abstract: A method for friction reduction during professional network expansion is implemented via a computing system including a processor. The method includes executing, via a network, an enterprise application on a remote computing system operated by a user associated with an enterprise and surfacing a professional networking UI on a display of the remote computing system during execution of the enterprise application. The method includes generating parameters that are representative of a connection between the user and each suggested professional contact based on enterprise-level data corresponding to the user and each suggested professional contact and generating friction-reducing UI elements for each suggested professional contact based on the generated parameters.

Abstract: A garment can include a textile that has moisture wicking and concealing properties. The textile may be strategically positioned such that a hydrophilic layer (with wicking properties) is positioned adjacent a skin surface of a wearer, and such that a hydrophobic layer, which has moisture concealing properties, is positioned external to the layer that has moisture wicking properties.

Abstract: An upper-body support garment that provides improved modesty and that can also be lighter weight, more sustainable, more comfortable, and/or include a desired aesthetic. The upper-body support garment can include a front portion having a laminate with one or more foam layers. The laminate layers are shaped and tailored to impart modesty to desired locations of the support garment without adding unnecessary bulk. The laminate can be integrated into a construction with flatter seams that can provide a desired aesthetic, be less likely to create skin irritations, and mitigate or eliminate visible pad lines.

Abstract: The following relates generally to smart home technology, home maintenance and upkeep, and home damage prevention and mitigation; and more specifically to generating and/or displaying home scores for a property. In some embodiments, one or more processors: retrieve attributes of a property; determine, from the attributes, (i) a property subscore, (ii) a safety subscore, (iii) a weather subscore, (iv) a connectivity subscore, and/or (v) a property insurance coverage subscore; generate an overall home score of the property based upon the subscores; and display (i) one or more of the home subscores, and (ii) the overall home score.

Abstract: The disclosed technology relates to a heat transfer fluid and a heat transfer system and heat transfer method employing the heat transfer fluid. In particular, the technology relates to a heat transfer fluid with low electrical conductivity, low flammability, and low freeze point that provides excellent peak temperature reduction in a heat transfer system, such as that for cooling a power system of an electric vehicle or computer electronics.

Abstract: The present disclosure provides a user interface and related methods for displaying the full treatment history of a patient undergoing orthodontic treatment.

Abstract: A system and method allows a light colored image of an object such as a check to be detected and captured on a light colored background for uploading to a server for processing. Detection involves detecting edges of objects on the image, drawing a rectangle around the detected edges, testing for an aspect ratio of the rectangle within an approved range, testing for the rectangle being outside of a margin of the image and being a certain percentage of the image, and testing for blur within a tolerable range.

Abstract: A mechanical circulatory support device is provided. The device has a housing containing separate first and second pumps. Each pump having an inlet, an outlet, and an impeller. The device also having a switching mechanism located within the housing and movable from a first position to a second position to divert blood flow within the housing to an inlet of one of the pumps and/or to bypass blood flow relative to one of the pumps within the housing.