Patents by Inventor Amy Lim
Amy Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240101714Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.Type: ApplicationFiled: June 15, 2023Publication date: March 28, 2024Inventors: Glen GIESE, Amy LIM, Josefine PERSSON, Justin SCHEER, Ambrose WILLIAMS
-
Patent number: 11725065Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.Type: GrantFiled: March 16, 2020Date of Patent: August 15, 2023Assignee: Genentech, Inc.Inventors: Glen Giese, Amy Lim, Josefine Persson, Justin Scheer, Ambrose Williams
-
Publication number: 20220203347Abstract: The present invention provides methods for cleaning or regenerating a chromatography material for reuse. The methods of the invention can be used for cleaning or regenerating ion exchange chromatography columns for reuse in the large-scale manufacture of multiple polypeptide products where the ion exchange chromatography column in used in overload mode.Type: ApplicationFiled: December 3, 2021Publication date: June 30, 2022Applicant: Genentech, Inc.Inventors: Marc L. Wong, Donna F. Quicho, Jason A. Brown, Josefine K. Persson, Amy Lim
-
Publication number: 20220135620Abstract: The present disclosure provides purification platforms comprising a depth filter step and/or a hydrophobic interaction chromatography (HIC) step and/or a MM-HIC/IEX chromatography step, and are useful for providing a method of reducing a hydrolytic enzyme activity rate of a composition obtained from said purification platforms. Also disclosed herein are methods of using the purification platforms described herein and compositions obtained therefrom, such as pharmaceutical compositions.Type: ApplicationFiled: October 28, 2021Publication date: May 5, 2022Inventors: Alex SEAY, Marc WONG, Stephen WOON, Michael LEE, Stefanie KHOO, William O'DWYER, Eileen DUENAS, Yinges YIGZAW, Amy LIM
-
Publication number: 20200317820Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.Type: ApplicationFiled: March 16, 2020Publication date: October 8, 2020Applicant: Genentech, Inc.Inventors: Glen GIESE, Amy LIM, Josefine PERSSON, Justin SCHEER, Ambrose WILLIAMS
-
Patent number: 10690671Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.Type: GrantFiled: July 24, 2018Date of Patent: June 23, 2020Assignee: Genentech, Inc.Inventors: Marc Wong, Liliana T. Yee, Amy Lim, Chris B. Fong
-
Patent number: 10626189Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.Type: GrantFiled: October 20, 2017Date of Patent: April 21, 2020Assignee: Genentech, Inc.Inventors: Glen Giese, Amy Lim, Josefine Persson, Justin Scheer, Ambrose Williams
-
Publication number: 20190202919Abstract: Provided herein are methods of purifying anti-c-met antibodies, compositions, and pharmaceutical formulations comprising purified anti-c-met antibodies, and methods of using the same.Type: ApplicationFiled: June 27, 2018Publication date: July 4, 2019Applicant: Genentech, Inc.Inventors: Marc WONG, Jerome J. BILL, JR., Arick M. BROWN, Glen S. GIESE, Judy Fay-Chen HSII, Amy LIM, Josefine PERSSON, Asha N. RADHAMOHAN, Maricel RODRIGUEZ
-
Publication number: 20190056399Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.Type: ApplicationFiled: July 24, 2018Publication date: February 21, 2019Applicant: Genentech, Inc.Inventors: Marc Wong, Liliana T. Yee, Amy Lim, Chris B. Fong
-
Patent number: 10073098Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.Type: GrantFiled: March 4, 2016Date of Patent: September 11, 2018Assignee: Genentech, Inc.Inventors: Marc Wong, Liliana T. Yee, Amy Lim, Chris B. Fong
-
Publication number: 20180162955Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.Type: ApplicationFiled: October 20, 2017Publication date: June 14, 2018Applicant: Genentech, Inc.Inventors: Glen GIESE, Amy LIM, Josefine PERSSON, Justin SCHEER, Ambrose WILLIAMS
-
Patent number: 9862778Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.Type: GrantFiled: April 11, 2014Date of Patent: January 9, 2018Assignee: GENENTECH, INC.Inventors: Glen Giese, Amy Lim, Josefine Persson, Justin Scheer, Ambrose Williams
-
Publication number: 20160370369Abstract: The present invention provides methods for producing disulfide oxidoreductase A (DsbA) and disulfide oxidoreductase C (DsbC) polypeptides at very high levels of purity. Also provided are ultrapure DsbA and DsbC and methods of using same, e.g., for use in immunoassays to show removal of DsbA and DsbC from biologics produced in bacteria.Type: ApplicationFiled: March 4, 2016Publication date: December 22, 2016Inventors: Marc WONG, Liliana T. YEE, Amy LIM, Chris B. FONG
-
Publication number: 20150050275Abstract: Provided herein are methods of purifying anti-c-met antibodies, compositions and pharmaceutical formulations comprising purified anti-c-met antibodies, and methods of using the same.Type: ApplicationFiled: October 10, 2014Publication date: February 19, 2015Applicant: GENENTECH, INC.Inventors: Marc Wong, Jerome Joseph Bill, JR., Arick Michael Brown, Glen Scott Giese, Judy Fay-Chen Hsii, Amy Lim, Josefine Persson, Asha Nandini Radhamohan, Maricel Rodriguez
-
Publication number: 20140336361Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.Type: ApplicationFiled: April 11, 2014Publication date: November 13, 2014Applicant: GENENTECH, INC.Inventors: GLEN GIESE, AMY LIM, JOSEFINE PERSSON, JUSTIN SCHEER, AMBROSE WILLIAMS
-
Patent number: 8161439Abstract: Method and apparatus for processing assertions in assertion-based verification of a logic design are described. One example relates to processing an assertion during verification of a logic design. An evaluation engine is generated that encodes, using a non-deterministic finite automata (NFA) model, temporal behavior of the logic design required by the assertion for a single attempt to evaluate the assertion. The evaluation engine is implemented in first reconfigurable hardware. The logic design is simulated over a plurality of clock events. Attempts to evaluate the assertion by the evaluation engine are preformed sequentially based on input stimuli obtained from the logic design during simulation thereof. Each of the attempts results in one of the assertion passing, the assertion failing, or the assertion requiring further evaluation.Type: GrantFiled: February 11, 2008Date of Patent: April 17, 2012Assignee: Cadence Design Systems, Inc.Inventors: Amy Lim, Ping-sheng Tseng, Yogesh Goel
-
Publication number: 20090204931Abstract: Method and apparatus for processing assertions in assertion-based verification of a logic design are described. One example relates to processing an assertion during verification of a logic design. An evaluation engine is generated that encodes, using a non-deterministic finite automata (NFA) model, temporal behavior of the logic design required by the assertion for a single attempt to evaluate the assertion. The evaluation engine is implemented in first reconfigurable hardware. The logic design is simulated over a plurality of clock events. Attempts to evaluate the assertion by the evaluation engine are preformed sequentially based on input stimuli obtained from the logic design during simulation thereof. Each of the attempts results in one of the assertion passing, the assertion failing, or the assertion requiring further evaluation.Type: ApplicationFiled: February 11, 2008Publication date: August 13, 2009Applicant: CADENCE DESIGN SYSTEMS, INC.Inventors: Amy LIM, Ping-sheng TSENG, Yogesh Goel
-
Publication number: 20070226693Abstract: A method of preparing a certification project plan for certifying compliance for a mobile platform project with pre-defined regulations is provided. The method includes defining the project in a software system and defining a certification plan for the project in the software system. The method also includes selecting authorized representatives based on their delegated authorities from a database to carry out the certification plan. The method can include verifying the completion of the certification plan and generating at least one document to indicate that the mobile platform is in compliance based on the completed certification plan.Type: ApplicationFiled: March 13, 2006Publication date: September 27, 2007Inventors: David Chatlain, Amy Lim
-
Patent number: 6913767Abstract: Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with antigen.Type: GrantFiled: April 30, 1997Date of Patent: July 5, 2005Assignee: Genentech, Inc.Inventors: Jeffrey L. Cleland, Amy Lim, Michael Frank Powell
-
Patent number: 5643605Abstract: Methods and compositions are provided for the encapsulation of adjuvants in PLGA microspheres for use as vaccines. Mixtures of microspheres are provided which release adjuvant at desired intervals to provide boosts with adjuvant.Type: GrantFiled: June 2, 1995Date of Patent: July 1, 1997Assignee: Genentech, Inc.Inventors: Jeffrey L. Cleland, Amy Lim, Michael Frank Powell