Abstract: A system and method for blood vessel stenosis visualization and navigation is disclosed. The CT system includes a rotatable gantry having an opening to receive a patient, an x-ray source positioned on the rotatable gantry to project x-rays toward a region-of-interest (ROI) of the patient that includes a plurality of blood vessels, an x-ray detector positioned on the rotatable gantry to receive x-rays emitted by the x-ray source and attenuated by the ROI, and a DAS operably connected to the x-ray detector. The CT system also includes a computer programmed to obtain CT image data for the ROI, reconstruct a 3D image of the plurality of blood vessels from the CT image data, automatically detect pathologies in the plurality of blood vessels, and identify the pathologies in the plurality of blood vessels on the 3D image, with a severity of the pathology being indicated on the 3D image.