Patents by Inventor AMY M. EHRENWORTH

AMY M. EHRENWORTH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF
    Publication number: 20220090154
    Abstract: Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same.
    Type: Application
    Filed: July 21, 2021
    Publication date: March 24, 2022
    Inventors: Pamela PERALTA-YAHYA, Amy M. EHRENWORTH
  • Pterin-dependent biocatalysts and uses thereof
    Patent number: 11085060
    Abstract: Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway biologically coupled to the pterin source. Tetrahydrobiopterin (referred to herein as BH4 or BH 4) can be the pterin source. The BH4 can be synthesized by a tetrahydrobiopterin synthesis pathway. The tetrahydrobiopterin synthesis pathway can include a GTP cyclohydrase; a pyruvoyl tetrahydropterin synthase; a sepiapterin reductase, and/or any combination thereof. The biocatalyst can further contain a pterin-dependent enzymatic pathway. The pterin-dependent enzymatic pathway can be amino acid mono-oxygenase, phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, nitric oxide synthase, alkylglycerol monooxygenase, and/or any combination thereof.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: August 10, 2021
    Assignee: GEORGIA TECH RESEARCH CORPORATION
    Inventors: Pamela Peralta-Yahya, Amy M. Ehrenworth
  • PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF
    Publication number: 20170362617
    Abstract: Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway biologically coupled to the pterin source. Tetrahydrobiopterin (referred to herein as BH4 or BH 4) can be the pterin source. The BH4 can be synthesized by a tetrahydrobiopterin synthesis pathway. The tetrahydrobiopterin synthesis pathway can include a GTP cyclohydrase; a pyruvoyl tetrahydropterin synthase; a sepiapterin reductase, and/or any combination thereof. The biocatalyst can further contain a pterin-dependent enzymatic pathway. The pterin-dependent enzymatic pathway can be amino acid mono-oxygenase, phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, nitric oxide synthase, alkylglycerol monooxygenase, and/or any combination thereof.
    Type: Application
    Filed: December 31, 2015
    Publication date: December 21, 2017
    Inventors: PAMELA PERALTA-YAHYA, AMY M. EHRENWORTH