Patents by Inventor Amy Putnam

Amy Putnam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS
    Publication number: 20260079159
    Abstract: The invention provides methods of isolating CD127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Application
    Filed: September 12, 2025
    Publication date: March 19, 2026
    Inventors: Jeffrey A. BLUESTONE, Weihong LIU, Amy PUTNAM
  • COMPOSITIONS AND METHODS FOR HEMATOPOIETIC STEM CELL TRANSPLANTS
    Publication number: 20260034175
    Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.
    Type: Application
    Filed: May 2, 2025
    Publication date: February 5, 2026
    Inventors: Nathaniel Fernhoff, Scott McClellan, Amy Putnam
  • CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ Tregs
    Patent number: 12436150
    Abstract: The invention provides methods of isolating CD 127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Grant
    Filed: July 7, 2022
    Date of Patent: October 7, 2025
    Assignee: The Regents of the University of California
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam
  • METHODS FOR ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
    Publication number: 20250144140
    Abstract: Various embodiments of the present disclosure provide therapeutic compositions and associated methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses.
    Type: Application
    Filed: October 15, 2024
    Publication date: May 8, 2025
    Inventors: Scott Killian, Scott McClellan, Amy Putnam, Nathaniel Fernhoff
  • CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS
    Publication number: 20230280341
    Abstract: The invention provides methods of isolating CD 127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Application
    Filed: July 7, 2022
    Publication date: September 7, 2023
    Applicant: The Regents of the University of California
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam
  • CD127 expression inversely correlates with FoxP3 and suppressive function of CD4 Tregs
    Patent number: 11435349
    Abstract: The invention provides methods of isolating CD127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: September 6, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam
  • CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS
    Publication number: 20180238880
    Abstract: The invention provides methods of isolating CD127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam
  • CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ tregs
    Patent number: 9977021
    Abstract: The invention provides methods of isolating CD127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 22, 2018
    Assignee: The Regents of the University of California
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam
  • CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS
    Publication number: 20150192582
    Abstract: The invention provides methods of isolating CD127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Application
    Filed: March 24, 2015
    Publication date: July 9, 2015
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam
  • CD127 expression inversely correlates with FoxP3 and suppressive function of CD4Tregs
    Patent number: 9012134
    Abstract: The invention provides methods of isolating CD127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: April 21, 2015
    Assignee: The Regents of the University of California
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam
  • CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS
    Publication number: 20080131445
    Abstract: The invention provides methods of isolating CD127lo/? immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
    Type: Application
    Filed: May 31, 2007
    Publication date: June 5, 2008
    Applicant: The Regents of the University of California
    Inventors: Jeffrey A. Bluestone, Weihong Liu, Amy Putnam