Patents by Inventor Amy R. Howell

Amy R. Howell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-O-SULFO-GALACTOSYLCERAMIDE ANALOGS AS ACTIVATORS OF TYPE II NKT CELLS AND USES THEREOF
    Publication number: 20210023110
    Abstract: Disclosed is a compound of the formula (I) or (II): wherein a f are as described herein. The compounds are useful in the activation of Type II NKT cells and in treating cancer.
    Type: Application
    Filed: March 25, 2019
    Publication date: January 28, 2021
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, University of Connecticut
    Inventors: Lise H. Pasquet, Jay A. Berzofsky, Amy R. Howell, Masaki Terabe, Kaddy Camara, Stewart K. Richardson
  • LACTONE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170313669
    Abstract: Provided herein are lactone compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as inhibitors of serine hydrolases, such as ABHD16A. Furthermore, the subject compounds and compositions may be useful for the treatment of, for example, PHARC and other neuroinflammatory diseases.
    Type: Application
    Filed: October 27, 2015
    Publication date: November 2, 2017
    Inventors: Benjamin F. CRAVATT, Siddhesh S. KAMAT, William H. PARSONS, Amy R. HOWELL, Kaddy CAMARA, Amy ANDERSON
  • Substituted oxetanes, method of making, and method of use thereof
    Patent number: 7687500
    Abstract: Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside analog related disorders such as disorders involving cellular proliferation and infection are also described.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: March 30, 2010
    Assignee: The University of Connecticut
    Inventors: Amy R. Howell, Rosa C. Taboada, Stewart K. Richardson
  • SUBSTITUTED OXETANES, METHOD OF MAKING, AND METHOD OF USE THEREOF
    Publication number: 20080139566
    Abstract: Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside analog related disorders such as disorders involving cellular proliferation and infection are also described.
    Type: Application
    Filed: January 24, 2008
    Publication date: June 12, 2008
    Inventors: Amy R. Howell, Rosa C. Taboada, Stewart K. Richardson
  • Substituted oxetanes, method of making, and method of use thereof
    Patent number: 7351827
    Abstract: Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside analog related disorders such as disorders involving cellular proliferation and infection are also described.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: April 1, 2008
    Assignee: The University of Connecticut
    Inventors: Amy R. Howell, Rosa C. Taboada, Stewart K. Richardson
  • Photoactivators, methods of use, and the articles derived therefrom
    Patent number: 7285363
    Abstract: A method for crosslinking one or more molecules comprises crosslinking the one or more molecules with a photactivatable crosslinker by one-photon or multi-photon excitation, wherein the crosslinker comprises at least two photoactive groups linked by a bridging moiety, and further wherein the point volume of the activation has at least one dimension of less than about 1 micron. The method is of particular utility for water-soluble molecules, particularly biologically active water-soluble molecules.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: October 23, 2007
    Assignee: The University of Connecticut
    Inventors: Paul J. Campagnola, Amy R. Howell, Jun Wang, Steven L. Goodman
  • Photoactivators, methods of use, and the articles derived therefrom
    Publication number: 20040259023
    Abstract: A method for crosslinking one or more molecules comprises crosslinking the one or more molecules with a photactivatable crosslinker by one-photon or multi-photon excitation, wherein the crosslinker comprises at least two photoactive groups linked by a bridging moiety, and further wherein the point volume of the activation has at least one dimension of less than about 1 micron. The method is of particular utility for water-soluble molecules, particularly biologically active water-soluble molecules.
    Type: Application
    Filed: November 10, 2003
    Publication date: December 23, 2004
    Inventors: Paul J. Campagnola, Amy R. Howell, Jun Wang, Steven L. Goodman
  • Catalytic oxidation of alcohols using manganese oxides
    Patent number: 6486357
    Abstract: A method of oxidizing an organic alcohol, wherein the organic alcohol is contacted with a stoichiometric excess of oxygen in the presence of an effective catalytic amount of a maganese-containing octahedral molecular sieve or octahedral layer. Primary alcohols are selectively oxidized to aldehydes, and secondary alcohols are selectively oxidized to ketones.
    Type: Grant
    Filed: August 14, 2001
    Date of Patent: November 26, 2002
    Assignee: The University of Connecticut
    Inventors: Steven L. Suib, Young Chan Son, Amy R. Howell
  • Catalytic oxidation of alcohols using manganese oxides
    Publication number: 20020128506
    Abstract: A method of oxidizing an organic alcohol, wherein the organic alcohol is contacted with a stoichiometric excess of oxygen in the presence of an effective catalytic amount of a manganese-containing octahedral molecular sieve or octahedral layer. Primary alcohols are selectively oxidized to aldehydes, and secondary alcohols are selectively oxidized to ketones.
    Type: Application
    Filed: August 14, 2001
    Publication date: September 12, 2002
    Inventors: Steven L. Suib, Young Chan Son, Amy R. Howell