Patents by Inventor Amy Rachel RAPPAPORT

Amy Rachel RAPPAPORT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HOMOLOGOUS ADENOVIRAL VACCINATION
    Publication number: 20240093235
    Abstract: Disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a homologous prime/boost vaccination strategy, such as adenoviral vectors for use in a homologous prime/boost vaccination strategy.
    Type: Application
    Filed: December 3, 2021
    Publication date: March 21, 2024
    Inventors: Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Amy Rachel Rappaport, Christine Denise Palmer
  • INFECTIOUS DISEASE ANTIGENS AND VACCINES
    Publication number: 20240050550
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: October 3, 2022
    Publication date: February 15, 2024
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer
  • ALPHAVIRUS NEOANTIGEN VECTORS
    Publication number: 20240024445
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: October 11, 2022
    Publication date: January 25, 2024
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • SARS-COV-2 VACCINES
    Publication number: 20230330215
    Abstract: Disclosed herein are vaccine compositions that include SARS-CoV-2 MHC epitope-encoding cassettes and/or full-length SARS-CoV-2 proteins. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: November 18, 2022
    Publication date: October 19, 2023
    Inventors: Roman Yelensky, Minh Duc Cao, Mike Zhong, Justin Helbert, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Amy Rachel Rappaport
  • ANTIGEN-ENCODING CASSETTES
    Publication number: 20230310563
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple repeats of distinct epitope-encoding sequences or having antigen-encoding nucleic acid sequences having less than 700 nucleotides and encoding multiple distinct epitope-encoding sequences. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: October 20, 2022
    Publication date: October 5, 2023
    Inventors: Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Multiepitope vaccine cassettes
    Patent number: 11771747
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: October 3, 2023
    Assignee: Gritstone Bio, Inc.
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
  • CAPPING COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20230303614
    Abstract: The present disclosure includes, among other things, non-natural nucleotides useful as 5? caps for RNA nucleotides. The present disclosure also includes, among other things, compositions and methods using delivery and vaccine RNA nucleotide compositions that include non-natural nucleotides as 5? caps.
    Type: Application
    Filed: October 20, 2022
    Publication date: September 28, 2023
    Inventors: Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Sue-Jean Hong, Arvin Akoopie
  • DURABLE VACCINATION
    Publication number: 20230047979
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
    Type: Application
    Filed: June 10, 2022
    Publication date: February 16, 2023
    Inventors: Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • SHARED NEOANTIGEN VACCINES
    Publication number: 20230020089
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccincation strategy.
    Type: Application
    Filed: May 4, 2022
    Publication date: January 19, 2023
    Inventors: Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Jennifer Busby, Brendan Bulik-Sullivan, Mojca Skoberne, Wade Blair
  • Alphavirus antigen vectors
    Patent number: 11510973
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: November 29, 2022
    Assignee: GRITSTONE BIO, INC.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Alphavirus neoantigen vectors
    Patent number: 11504421
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: November 22, 2022
    Assignee: GRITSTONE BIO, INC.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • MULTIEPITOPE VACCINE CASSETTES
    Publication number: 20220265797
    Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines.
    Type: Application
    Filed: April 22, 2022
    Publication date: August 25, 2022
    Inventors: Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
  • Alphavirus neoantigen vectors
    Patent number: 11419929
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: August 23, 2022
    Assignee: GRITSTONE BIO, INC.
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • Alphavirus Antigen Vectors
    Publication number: 20220226453
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: March 11, 2022
    Publication date: July 21, 2022
    Inventors: Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
  • ALPHAVIRUS NEOANTIGEN VECTORS AND INTERFERON INHIBITORS
    Publication number: 20220125919
    Abstract: Disclosed herein are vectors that include alphavirus-based expression platforms. Also disclosed are methods associated with the alphavirus-based expression platforms and co-administration of an inhibitor of Type I interferon signaling.
    Type: Application
    Filed: November 7, 2019
    Publication date: April 28, 2022
    Inventors: Karin Jooss, Amy Rachel Rappaport, Leonid Gitlin
  • IMMUNE CHECKPOINT INHIBITOR CO-EXPRESSION VECTORS
    Publication number: 20210213122
    Abstract: Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: May 23, 2019
    Publication date: July 15, 2021
    Applicant: Gritstone Oncology, Inc.
    Inventors: Wade Blair, Karin Jooss, Leonid Gitlin, Ciaran Daniel Scallan, Amy Rachel Rappaport, Gijsbert Grotenbreg
  • ALPHAVIRUS NEOANTIGEN VECTORS
    Publication number: 20200197500
    Abstract: Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
    Type: Application
    Filed: May 8, 2018
    Publication date: June 25, 2020
    Inventors: Wade BLAIR, Karin JOOSS, Amy Rachel RAPPAPORT, Ciaran Daniel SCALLAN, Leonid GITLIN