Patents by Inventor Amy Simcoe

Amy Simcoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleoside derivatives as inhibitors of rna-dependent RNA viral polymerase
    Publication number: 20070275912
    Abstract: The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
    Type: Application
    Filed: December 21, 2006
    Publication date: November 29, 2007
    Inventors: Balkrishen Bhat, Anne Eldrup, Thazha Prakash, Phillip Cook, Robert LeFemina, Amy Simcoe, Carrie Rutkowski, Mario Valenciano
  • Hcv rna dependent rna polymerase
    Publication number: 20070149761
    Abstract: The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA polymerases, to evaluate the effectiveness of a compound to inhibit NS5B activity.
    Type: Application
    Filed: January 6, 2005
    Publication date: June 28, 2007
    Inventors: Donald Graham, Amy Simcoe, Steven Ludmerer, Osvaldo Flores, Robert LaFemina
  • Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
    Publication number: 20050272676
    Abstract: The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
    Type: Application
    Filed: August 9, 2005
    Publication date: December 8, 2005
    Inventors: Balkrishen Bhat, Anne Eldrup, Thazha Prakash, Phillip Cook, Robert LaFemina, Amy Simcoe, Carrie Rutkowski, Mario Valenciano