Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids are disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5?-end, 3?-end or 5?-end and 3?-ends, and compounds that can be used to make the modified nucleic acids arc disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.

Abstract: An e-mail sender is provided with an option to send a notification to the prospective recipient(s) of an e-mail indicating to the recipient that an e-mail has been sent to his or her attention or to a business or other entities attention. The notification can be advantageously sent by a different communications route, such as by mail, courier, telephone call, facsimile, social network, or other method. Back up notifications can also be sent on an automated basis. The notification can be sent automatically and/or sent a period of time after the e-mail is sent if an acknowledgment or reply is not received.

Abstract: An e-mail sender is provided with an option to send a notification to the prospective recipient(s) of an e-mail indicating to the recipient that an e-mail has been sent to his or her attention or to a business or other entities attention. The notification can be advantageously sent by a different communications route, such as by mail, courier, telephone call, facsimile, social network, or other method. Back up notifications can also be sent on an automated basis. The notification can be sent automatically and/or sent a period of time after the e-mail is sent if an acknowledgment or reply is not received.

Abstract: A container for dispensing nasal spray, ear drops, or an inhalant mist, formed in the three-dimensional shape of an entertaining figurine, such as an elephant, or a toy, having appendages which serve as handles for grasping and manipulating the container to administer the spray or mist to a child.

Abstract: A container for dispensing nasal spray, ear drops, or an inhalant mist, formed in the three-dimensional shape of an entertaining figurine, such as an elephant, or a panda bear, having appendages which serve as handles for grasping and manipulating the container to administer the spray or mist to a child. The container for dispensing an inhalant mist preferably has a mechanism for counting the number of puffs dispensed and for displaying the count.