Abstract: Determining correct base container images to support custom container images is provided. A comparison between layers of a base container image corresponding to a current version of an operand and layers of a custom container image built by a user is performed using an operator. It is determined whether the user utilized a correct base container image to build the custom container image based on the comparison between the layers of the base container image corresponding to the current version of the operand and the layers of the custom container image built by the user. A runtime is generated in a cluster of host nodes to provide a service based on the custom container image in response to determining that the user utilized the correct base container image to build the custom container image.

Abstract: Determining correct base container images to support custom container images is provided. A comparison between layers of a base container image corresponding to a current version of an operand and layers of a custom container image built by a user is performed using an operator. It is determined whether the user utilized a correct base container image to build the custom container image based on the comparison between the layers of the base container image corresponding to the current version of the operand and the layers of the custom container image built by the user. A runtime is generated in a cluster of host nodes to provide a service based on the custom container image in response to determining that the user utilized the correct base container image to build the custom container image.

Abstract: Techniques and system configurations for demand-based product sourcing in an electronic commerce setting is described herein. In one example, information about an item corresponding to a plurality of fulfillment locations is stored in a database. The information includes a plurality of transit times and a plurality of transit costs corresponding to each of the plurality of transit times. A subset of transit times is selected upon receiving a location of a user. A subset of transit costs corresponding with the subset of transit times is selected. An indication of a selection of a transit time is received. The indication includes the item, a quantity of the item, and a destination. A preferred fulfillment location of a subset of fulfillment locations is calculated, the calculating using the transit time, the location, and a selection rule, wherein the selection rule is generated using a plurality of selection attributes.

Abstract: Techniques and system configurations for demand-based product sourcing in an electronic commerce setting is described herein. In one example, information about an item corresponding to a plurality of fulfillment locations is stored in a database. The information includes a plurality of transit times and a plurality of transit costs corresponding to each of the plurality of transit times. A subset of transit times is selected upon receiving a location of a user. A subset of transit costs corresponding with the subset of transit times is selected. An indication of a selection of a transit time is received. The indication includes the item, a quantity of the item, and a destination. A preferred fulfillment location of a subset of fulfillment locations is calculated, the calculating using the transit time, the location, and a selection rule, wherein the selection rule is generated using a plurality of selection attributes.

Abstract: A novel and efficient single pot synthetic schemes are disclosed for preparing modified nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs. The novel method is used to prepare nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs having non-persistent or persistent and non-persistent modifications. Novel biomolecular reactions are also disclosed using the novel modified biomolecules disclosed herein.

Abstract: Modified nucleotides are disclosed for use in single molecule sequencing, methods for making the modified nucleotides and method for using the modified nucleotides. Linkers for making the modified nucleotide are also disclosed.

Abstract: Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.

Abstract: Agents and methods for qualitative and quantitative analysis a protein complex or protein complexes using isotope-labeled symmetrical bifunctional crosslinkers and mass spectrometry are provided. Targeting moieties, cell permeability moieties, or affinity moieties, may be appended to the bifunctional crosslinkers. The isotope-labeled symmetrical bifunctional crosslinkers may be used in a kit or as a library.