Patents by Inventor Amy Yan

Amy Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preparing targeted aptamer prodrugs
    Patent number: 9540412
    Abstract: The present invention provides methods of preparing an oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells, the method comprising (1) selecting a targeted aptamer, internalizing nucleic acid or tumor-homing nucleic acid via iterative rounds of selection, and (i) hybridizing it to an oligonucleotide, (ii) replacing one or more nucleotide with a nucleoside or nucleoside analog, or (iii) synthesizing the it with one or more nucleoside or nucleoside analogs; or (2) preparing a naive combinatorial aptamer, internalizing nucleic acid or tumor-homing nucleic acid prodrug library, and running iterative rounds of selection for the cells. The present invention also provides the agent, the pharmaceutical composition, and methods of treating or preventing cancer and/or viral infection, the method comprising administration of the oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: January 10, 2017
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Matthew Levy, Amy Yan, Brian Wengerter
  • METHODS OF PREPARING TARGETED APTAMER PRODRUGS
    Publication number: 20130123478
    Abstract: The present invention provides methods of preparing an oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells, the method comprising (1) selecting a targeted aptamer, internalizing nucleic acid or tumor-homing nucleic acid via iterative rounds of selection, and (i) hybridizing it to an oligonucleotide, (ii) replacing one or more nucleotide with a nucleoside or nucleoside analog, or (iii) synthesizing the it with one or more nucleoside or nucleoside analogs; or (2) preparing a naive combinatorial aptamer, internalizing nucleic acid or tumor-homing nucleic acid prodrug library, and running iterative rounds of selection for the cells. The present invention also provides the agent, the pharmaceutical composition, and methods of treating or preventing cancer and/or viral infection, the method comprising administration of the oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells.
    Type: Application
    Filed: April 29, 2011
    Publication date: May 16, 2013
    Inventors: Matthew Levy, Amy Yan, Brian Wengerter
  • Selection method for cell internalizing nucleic acids
    Patent number: 8298764
    Abstract: The present invention includes compositions and methods for contacting one or more cells with a random RNA-containing library, treating the contacted cells and with a denaturing agent or digestion with one or more nucleases, and extracting from the cells one or more internalized nucleic acids resistant to the nucleases or denaturants.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: October 30, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventors: Andrew D. Ellington, Matthew Levy, Amy Yan, Ted Chitai Chu
  • Selection Method for Cell Internalizing Nucleic Acids
    Publication number: 20090170711
    Abstract: The present invention includes compositions and methods for contacting one or more cells with a random RNA-containing library, treating the contacted cells and with a denaturing agent or digestion with one or more nucleases, and extracting from the cells one or more internalized nucleic acids resistant to the nucleases or denaturants.
    Type: Application
    Filed: April 9, 2008
    Publication date: July 2, 2009
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Andrew D. Ellington, Matthew Levy, Amy Yan, Chi-Tai Chu