Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: The present disclosure provides methods for treating a subject having a HER2 non-amplified (HER2-negative) cancer or low HER2 expressing (HER2-low) cancer, comprising detecting expression of a BCAR4 gene fusion in a biological sample from the subject. If expression of the BCAR4 gene fusion is detected, a HER2-targeted cancer treatment is administered to the subject; if expression of the BCAR4 gene fusion is not detected, a cancer treatment that is not HER2-targeted is administered to the subject. Methods of predicting response to a HER2-targeted cancer treatment and detecting BCAR4 or BCAR4 gene fusion activation are also provided.

Abstract: Systems and methods are described for merging customer profiles, such as may be implemented by a computer-implemented contact center service. In some aspects, a subset of profiles may be determined that satisfy merging criteria, where individual profiles include a plurality of data fields. At least one value in a first data field that conflicts between at least two profiles may be identified. Next a merged value may be selected for the first data field based on data deduplication criteria, where the data deduplication criteria includes at least one indicator of accuracy of values of the plurality of data fields. As a result of a determination that at least the subset of profiles of the group of profiles meet the merging criteria, at least the subset of profiles may be combined into a combined profile using the merged value.

Abstract: Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies.

Abstract: The present disclosure provides novel heteroaryl compounds of formula (VII). Such compounds are useful for the treatment of cancers.

Abstract: One or more servers can implement a method including generating an information resource comprising a content package including first content, metadata of a content extension, and a script for displaying the first content, and transmitting the information resource to a client device to cause the client device to: display the first content within an inline frame; identify an interaction with a user interface feature; transmit, responsive to identifying the interaction, a content extension request based on the metadata of the content extension; receive, responsive to the content extension request, a second content item; responsive to identifying the interaction, expand the inline frame from the first size to a second size; and display, in the expanded inline frame, the second content item, the second content item different from the first content item.

Abstract: A method for data-driven professional network expansion techniques is implemented via a computing system including a processor. The method includes executing, via a network, an enterprise application on a remote computing system operated by a user associated with an enterprise and surfacing a professional networking UI on a display of the remote computing system during execution of the enterprise application. The method includes accessing enterprise-level data corresponding to the user and the enterprise, extracting parameters associated with the user and the enterprise from the enterprise-level data, and automatically generating, based on the extracted parameters, the user's professional network and a list of suggested professional contacts.

Abstract: A door interface system for a vehicle door includes a sensor and a visual indicator. The sensor may be a proximity sensor and may be positioned proximate to the visual indicator such that it will detect an object proximate to the proximity sensor. The visual indicator may convey the position of the sensor and/or a status of the vehicle door. The door interface system is configured to control the vehicle door based at least in part on detecting an object proximate the visual indicator.

Abstract: The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.

Abstract: A snow melting system and method for operating a snow sensor is provided. The snow melting system includes a controller, a heating system, and a snow sensor. The snow sensor comprises a support structure and a cap. The support structure includes a proximal end and a distal end, where a first plane defined by the distal end is angled with respect to a second plane defined by the proximal end. The cap is disposed at the distal end of the support structure and comprises a top surface, a side surface arranged orthogonal to the top surface, and a chamfer that extends between the side surface and the top surface.

Abstract: A methodology of detecting pathogens captured respectively from the inhalation and the exhalation in human breathing is disclosed. More particularly, a method is described for simultaneously detecting pathogens captured on sensors placed respectively inside an inhalation channel and an exhalation channel of a nose respirator.

Abstract: A nose respirator device with a holder connected to a base, the holder has a top sitting across the nasal bridge and two arms extending downward to join with the base, which sits across the subnasale and contains two open cavities with upper openings capable of being inserted into each nostril. Each cavity can be further divided by a separator into two channels for inhalation and exhalation, respectively. One-way air flow in each channel can be further ensured with valves, which open only in one direction upon the push of air current. Filters can be fitted into each cavity or channel for air cleaning. One or more attachments can be fitted onto the base for additional purposes, which include extra filtration and disinfection. The area within the holder and the base can be covered with a sheet, which can also be used for device classification and user identification.

Abstract: An optical system for responding to distortions in incident light in a free space optical communication system includes a machine learning output storing at least an indication of multiple images and corresponding positioning or orientation attributes for one or more optical elements; a sensor configured to generate an image; and a component configured to adjust the one or more optical elements based on the generated image. Various other methods, systems, and apparatuses are also disclosed.

Abstract: In one embodiment, a method includes receiving an image on a computing device. The computing device may further execute a classification algorithm to determine whether a target feature is present in the received image. As an example, the classification algorithm may determine whether a building is depicted in the received image. In response to determining that a target feature is present, the method further includes using a segmentation algorithm to segment the received image for the target feature. Based on a determined footprint size of the target feature, a distribution of statistical information over the target feature in the image can be calculated.

Abstract: In one embodiment, a method includes receiving an image on a computing device. The computing device may further execute a weakly-supervised classification algorithm to determine whether a target feature is present in the received image. As an example, the weakly-supervised classification algorithm may determine whether a building is depicted in the received image. In response to determining that a target feature is present, the method further includes using a weakly-supervised segmentation algorithm of the convoluted neural network to segment the received image for the target feature. Based on a determined footprint size of the target feature, a distribution of statistical information over the target feature in the image can be calculated.

Abstract: An optical system for responding to distortions in incident light in a free space optical communication system includes a machine learning output storing at least an indication of multiple images and corresponding positioning or orientation attributes for one or more optical elements; a sensor configured to generate an image; and a component configured to adjust the one or more optical elements based on the generated image. Various other methods, systems, and apparatuses are also disclosed.

Abstract: An optical system for responding to distortions in incident light in a free space optical communication system comprises a machine learning output storing at least an indication of multiple images and corresponding positioning or orientation attributes for one or more optical elements; a sensor configured to generate an image; and a component configured to adjust the one or more optical elements based on the generated image.

Abstract: In one embodiment, a method includes receiving an image on a computing device. The computing device may further execute a weakly-supervised classification algorithm to determine whether a target feature is present in the received image. As an example, the weakly-supervised classification algorithm may determine whether a building is depicted in the received image. In response to determining that a target feature is present, the method further includes using a weakly-supervised segmentation algorithm of the convoluted neural network to segment the received image for the target feature. Based on a determined footprint size of the target feature, a distribution of statistical information over the target feature in the image can be calculated.

Abstract: A method to detect a number of individual users included in a composite set of movie ratings having ratings from a plurality of individual users includes accessing the composite set of movie ratings and movie profiles and loading the composite set and movie profiles into a rating analysis engine. Processing the composite set along with the movie profiles determines a number of partitions present in the composite set, wherein the number of partitions is determined iteratively using subspace clustering of ratings from the composite set. The determined number of partitions is output and corresponds to the number of individual users included in the composite set of movie ratings.