Abstract: The present disclosure provides methods and compositions, e.g., kits, for detecting homologous recombination deficiency in a cancer patient. In certain embodiments, the methods disclosed are based on genomic copy number summarization and deep learning model to detect homologous recombination deficiency from extremely low coverage whole genome sequencing data.

Abstract: A method of preparing a dye-functionalized flexible upconversion-luminescence solid-phase sensor, including: preparation of upconversion-luminescence nanoparticles, preparation of an upconversion nanoparticle-doped solid-phase sensor, and preparation of a dye-functionalized flexible upconversion-luminescence solid-phase sensor. A method for detecting a gaseous pollutant is also provided, including: preparing a dye-functionalized flexible upconversion-luminescence solid-phase sensor through the above method; establishing a prediction model; and substituting a fluorescence intensity of a sample into the prediction model to calculate the gaseous pollutant concentration in the sample.

Abstract: An anesthesia machine, anesthesia control method and system are provided. The anesthesia machine controls the infusion device, or the control terminal controls the anesthesia machine and infusion device, such that the doctor controls the inhalation and intravenous infusion of anesthetics for patient with only one device, without walking back and forth between multiple devices, which improves the efficiency of anesthesia control.

Abstract: The present disclosure relates to a hierarchical constraint (HC) based method and system for classifying fine-grained graptolite images. The method includes: constructing a graptolite fossil dataset; extracting features in graptolite images; calculating the similarity between graptolite images, and performing weighting according to a genetic relationship among species to obtain a weighted HC loss function (HC-Loss) of all graptolite images; calculating cross-entropy loss; taking a weighted sum of HC-Loss and CE-Loss as a total loss function in a training stage; and performing model training. The system of the present disclosure includes a processor and a memory.

Abstract: Disclosed are compounds, compositions, and methods for treating and/or preventing infection by viruses that utilize the angiotensin converting enzyme 2 (ACE2) as a cellular receptor such as sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Particularly disclosed are recombinant ACE2-Fc fusion proteins and ACE2 variants that exhibit anti-SARS-CoV-2 binding activity and decouple anti-SARS-CoV-2 activity from side effects such as cardiovascular effects, where the fusion proteins and variants exhibit reduced ACE2 enzymatic activity.

Abstract: A bidirectional signal conversion circuit is configured to perform a signal conversion between a first port and a second port, and includes a switch, a first pull-up resistor, a second pull-up resistor, a first output-response enhancement circuit, and a second output-response enhancement circuit. The switch is coupled between the first port and the second port, and operates according to a bias. The first (second) pull-up resistor is coupled between the first (second) port and a high (low) voltage terminal having a high (low) voltage. The first (second) output-response enhancement circuit includes a first (second) alternative-current (AC) coupling circuit and a first (second) output-stage circuit. When the first (second) port and the second (first) port functions as an input port and an output port respectively, the first (second) output-response enhancement circuit is operable to accelerate the transient response of the output port.

Abstract: The present invention relates to a wall-mounted screen bracket, comprising a screen bracket main body and a tray, the tray is arranged on the screen bracket main body, an extension socket installation structure and a threading opening are arranged on the tray, the extension socket is arranged and fixed in the extension socket installation structure, and the power cord of the extension socket is connected with the outside world through the threading opening. The present invention is also concerned with a wall-mounted screen bracket system, which includes the wall-mounted screen bracket and an extension socket arranged on the extension socket installation structure.

Abstract: A package structure includes a first redistribution layer, a semiconductor die, and through vias. The first redistribution layer includes dielectric layers, first conductive patterns, and second conductive patterns. The dielectric layers are located in a core region and a peripheral region of the first redistribution layer. The first conductive patterns are embedded in the dielectric layers in the core region, wherein the first conductive patterns are arranged in the core region with a pattern density that gradually increases or decreases from a center of the core region to a boundary of the core region. The second conductive patterns are embedded in the dielectric layers in the peripheral region. The semiconductor die is disposed on the core region over the first conductive patterns. The through vias are disposed on the peripheral region and electrically connected to the second conductive patterns.

Abstract: A positive electrode active material of a lithium ion battery includes lithium manganese iron phosphate and a ternary material. A negative electrode active material is graphite. The lithium ion battery meets the following formulas: 1.08 ? M 3 * ? 3 * y / M 1 * ? 1 * A 1 + M 2 * ? 2 * A 2 * x ? 1.12 ? and 0.49 ? M 1 * 1 - ? ? 1 * A 1 + M 2 * 1 - ? 2 * A 2 * x / M 3 * 1 ? - ? 3 * y ? 1.

Abstract: The present disclosure relates to nanoparticles and methods for polynucleotide transfection.

Abstract: A rotary engine includes a housing, a crank dual-slider connecting rod mechanism, and rotary casings. The vertically arranged sliding grooves are provided in the housing. The crank dual-slider connecting rod mechanism is mounted on the housing. Sliders of the crank dual-slider connecting rod mechanism are respectively located in the sliding groove. The sliders are driven by a rotation of a crank to periodically compress a gas in the sliding grooves. The two rotary casings configured to rotate synchronously are mounted on an outer side of the housing. Each of the rotary casings is provided with a combustion chamber. Any of the rotary casings is in a transmission connection with a main shaft via a transmission system. The rotary casings drive the main shaft to rotate through a combustion of a compressed gas in the combustion chambers. The rotary engine achieves a good seal.

Abstract: The treatment system provides a feature that may reduce cost of the electrochemical plating process by reusing the virgin makeup solution in the spent electrochemical plating bath. The treatment system provides a rotating filter shaft which receives the spent electrochemical plating bath and captures the additives and by-products created by the additives during the electrochemical plating process. To capture the additives and the by-products, the rotating filter shaft includes one or more types of membranes. Materials such as semi-permeable membrane are used to capture the used additives and by-products in the spent electrochemical plating bath. The treatment system may be equipped with an electrochemical sensor to monitor a level of additives in the filtered electrochemical plating bath.

Abstract: The present disclosure provides a high-pressure helium shale porosity testing device and method. The device comprises a reference cylinder, a pressure cylinder, a sample cylinder, a differential pressure sensor, a pressure gauge, an venting and vacuumizing system, a temperature control system and a tubing and valve system, wherein the reference cylinder is respectively connected with a helium source, the pressure cylinder and the sample cylinder through the tubing and valve system, the differential pressure sensor is configured to measure changes of pressure difference between the sample cylinder and the pressure cylinder, the pressure gauge is configured to measure pressure at the pressure cylinder, the sample cylinder is further connected with the venting and vacuumizing system through the tubing and valve system, and the temperature control system is used for controlling the temperature of the whole device.

Abstract: A method includes forming a fin on a substrate, forming an insulating material over the fin, recessing the insulating material to form an isolation region surrounding the fin, wherein an upper portion of the fin protrudes above the isolation region, performing a trimming process to reduce a width of the upper portion of the fin, and forming a gate structure extending over the isolation region and the upper portion of the fin.

Abstract: In an example, an apparatus comprises a lead frame that includes a first row of leads, a first pad coupled to the first row of leads, and a second row of leads parallel to the first row of leads. The lead frame also includes a second pad coupled to the second row of leads. The first and second pads are separated by a gap, and each of the first and second pads has a substantially uniform thickness. The apparatus also includes a device coupled to the first and second pads. The first and second pads are exposed to an exterior of the apparatus.

Abstract: The present disclosure provides a detection system and a detection method. The microphone of the detection system receives the response signal formed according to the shape of the sealed cavity. The conversion unit transfers the response signal in the time domain to the frequency domain signal in the frequency domain. The calculation unit obtains every frequency value corresponding to the frequency gradient being zero of each frequency waveform which is chosen of the response signal. The average unit averages every frequency value corresponding to the frequency gradient being zero of each chosen frequency waveform into the average frequency value and outputs an average frequency value. The determination unit determines whether the average frequency value is located in the corresponding frequency tolerance range, so that the wearing status of the in-ear earphone is confirmed.

Abstract: A semiconductor device structure, along with methods of forming such, are described. The structure includes a first and second gate electrode layers, and a dielectric feature disposed between the first and second gate electrode layers. The dielectric feature has a first surface. The structure further includes a first conductive layer disposed on the first gate electrode layer. The first conductive layer has a second surface. The structure further includes a second conductive layer disposed on the second gate electrode layer. The second conductive layer has a third surface, and the first, second, and third surfaces are coplanar. The structure further includes a third conductive layer disposed over the first conductive layer, a fourth conductive layer disposed over the second conductive layer, and a dielectric layer disposed on the first surface of the dielectric feature. The dielectric layer is disposed between the third conductive layer and the fourth conductive layer.

Abstract: Disclosed are compounds of Formula (I?) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: A method for forming a fin field effect transistor device structure includes forming a first fin structure in an input/output region of the substrate with a fin top layer and a hard mask layer over the first fin structure. The method also includes forming a dummy oxide layer across the first fin structure. The method also includes forming a dummy gate structure over the dummy oxide layer across the first fin structure. The method also includes forming spacers on opposite sides of the dummy gate structure. The method also includes removing the dummy gate structure over the first fin structure. The method also includes removing the dummy oxide layer and trimming the first fin structure. The method also includes forming a first oxide layer across the first fin structure. The method also includes forming a first gate structure over the first oxide layer across the first fin structure.

Abstract: A method includes providing a structure having two fins extending from a substrate; an isolation structure isolating bottom portions of the fins; source/drain (S/D) features over each of the fins; a dielectric fin oriented lengthwise parallel to the fins and disposed between the two fins and over the isolation structure; a dummy gate stack over the isolation structure, the fins, and the dielectric fin; and one or more dielectric layers over sidewalls of the dummy gate stack. The method further includes removing the dummy gate stack to result in a gate trench within the one or more dielectric layers, wherein the dielectric fin is exposed in the gate trench; trimming the dielectric fin to reduce a width of the dielectric fin; and after the trimming, forming a high-k metal gate in the gate trench.