Abstract: A protein analysis platform includes a platform body comprising: a gel working unit provided in a top portion of the platform body and comprising a gel accommodation area for accommodating at least one gel; at least one electrophoresis tank provided along a side of the gel accommodation area and provided with at least one electrode; and a blotting layer stack provided in a bottom portion of the gel working unit and comprising an electrode layer; wherein a removable bottom plate is provided between the gel working unit and the blotting layer stack and detachably corresponds to a bottom side of the gel accommodation area. The protein analysis platform is used for western blotting or next-generation western blotting, wherein the protein analysis platform can quickly complete steps such as gel casting, electrophoresis, and blotting in one platform.

Abstract: Methods are provided for identifying Alzheimer's disease cells or subjects, based on the methylation status of multiple methylation markers in genomic DNA. Also provided are methods for identifying therapeutic agents for treating Alzheimer's disease by monitoring changes in the methylation status of multiple methylation markers.

Abstract: A dust collecting attachment includes a dust suction portion and a main body. The main body has a dust collection passage communicated with the dust suction portion. The dust suction portion has a negative pressure by exerting a suction force to the dust collection passage from a hose. The dust suction portion includes an inner pipe through which a tip tool passes, a first dust suction flow passage, and a second dust suction flow passage. The first dust suction flow passage opens a first suction opening to a side of a workpiece in an outside in a radial direction of the inner pipe and is communicated with the dust collection passage. The second dust suction flow passage opens a second suction opening to an opposite side of the workpiece in the outside in the radial direction of the inner pipe and is communicated with the dust collection passage.

Abstract: A dust collecting attachment includes a dust suction portion and a main body. The dust suction portion has a suction opening through which a tip tool is allowed to pass. The main body has a dust collection passage communicated with the dust suction portion and connectable to an external hose. The main body includes a suction space, an air vent hole, and an air vent operation portion. The suction space is communicated with the dust collection passage and has a suction port opening to a workpiece. The air vent hole opens the suction space to outside. The air vent operation portion normally closes the air vent hole and opens the air vent hole by a predetermined operation. The air vent operation portion is operated together with an operation of removing the main body from the workpiece to open the air vent hole.

Abstract: The present disclosure relates to enriching nucleic acid from a sample. In some embodiments, the present disclosure provides methods for enriching at least one targeted nucleic acid, identifying genome-wide gene editing off-targets, and evaluating gene editing efficiency from a sample comprising a plurality of single-strand nucleic acid fragments. Others example embodiments are also described herein.

Abstract: Disclosed herein is a nanocomposite comprising a core-shell nanoparticle and a core-shell quantum dot. The core-shell nanoparticle comprises a phosphor core, a shell layer, and a cleavable peptide. The core-shell quantum dot comprises a center core, an intermediate layer, an outer layer, a silica layer, and an arginylglycylaspartic acid (RGD) peptide. The core-shell nanoparticle and the core-shell quantum dot are linked to each other via forming a peptide bond between the cleavable peptide and the RGD peptide. Also disclosed are the uses of the nanocomposite in making a diagnosis of tumors.

Abstract: The present invention relates to a reaction platform, which comprises: a machine body with a bottom plate for placing non-porous substrates; and a coater module configured on the top of the machine body and capable of maintaining a preset of a predetermined height for moving along the surface of non-porous substrate, wherein the coater module has one or more slits, and a target liquid can be directly injected or sucking in from the outside of the coater module through the slit, and spreading the target liquid onto a surface of the non-porous substrate while moving along the non-porous substrate; wherein the surface of the non-porous substrate has a target to be coated. The reaction platform of the present invention can not only save time, labor and cost, but also have accurate and reproducible experimental results, showing better results than traditional methods.

Abstract: A sample preparation mould and a sample preparation method for the triaxial test of MSW are provided. In the present invention, the cylindrical main mould comprises two curved steel pieces, and the two sides of each curved steel piece have a stretched connection part; the two curved steel pieces are connected with each other and clamped by two steel clamps; porous stones are arranged at two ends of the cylindrical main mould and fixed separately by a top limiting lantern ring and a bottom lantern ring; the top limiting lantern ring is detachably connected to the top hopper, from which MSW materials are input; the cylindrical main mould is radially constrained in four positions, and the two ends thereof are axially constrained, thereby significantly improving stability during compacting and hence ensuring the axial and radial sizes of the MSW sample.

Abstract: Disclosed herein is a micro-reactor for synthesizing a molecule, for example, compound, a nanoparticle, or a quantum dot. According to embodiments of the present disclosure, the apparatus comprises a processor, a storage unit, a reaction unit, a detector, and a collector, in which the storage unit and the reaction unit are independently controlled by the process. Optionally, the present micro-reactor further comprises a diagnostic device for performing a diagnostic test on a biological sample by use of the molecule. Also disclosed wherein are methods of diagnosing and treating a disease in a subject with the aid of the present micro-reactor.

Abstract: The lack of blood-brain barrier (BBB) penetrating ability has hindered the delivery of many therapeutic agents for tauopathy therapeutic treatment. A circular bifunctional aptamer reported here has been able to enhance the in vivo BBB penetration for improved therapy. The circular aptamer includes one transferrin receptor (TfR) aptamer to facilitate TfR-aptamer recognition-induced transcytosis across BBB endothelial cells, and one Tau protein aptamer selected to inhibit Tau phosphorylation and other tauopathy-related pathological events in the brain. This bispecific construct exhibits strong specificity towards Tau and enhanced plasma stability in comparison to linear Tau aptamer. In vivo administration of circular Tau-TfR aptamer results in a rapid uptake into relevant brain regions after crossing the BBB, such as hippocampus and cortex.

Abstract: Disclosed herein is a micro-reactor for synthesizing a molecule, for example, compound, a nanoparticle, or a quantum dot. According to embodiments of the present disclosure, the apparatus comprises a processor, a storage unit, a reaction unit, a detector, and a collector, in which the storage unit and the reaction unit are independently controlled by the process. Optionally, the present micro-reactor further comprises a diagnostic device for performing a diagnostic test on a biological sample by use of the molecule. Also disclosed wherein are methods of diagnosing and treating a disease in a subject with the aid of the present micro-reactor.

Abstract: Disclosed herein is a nanocomposite comprising a core-shell nanoparticle and a core-shell quantum dot. The core-shell nanoparticle comprises a phosphor core, a shell layer, and a cleavable peptide. The core-shell quantum dot comprises a center core, an intermediate layer, an outer layer, a silica layer, and an arginylglycylaspartic acid (RGD) peptide. The core-shell nanoparticle and the core-shell quantum dot are linked to each other via forming a peptide bond between the cleavable peptide and the RGD peptide. Also disclosed are the uses of the nanocomposite in making a diagnosis of tumors.

Abstract: The present disclosure provides a data processing method. The data processing method includes acquiring a first original image and performing a first processing on the first original image to obtain a first processed image, a resolution parameter of the first processed image and the resolution parameter of the first original image having a first difference; and acquiring a second original image and performing a second processing on the second original image to obtain a second processed image. The resolution parameter of the second processed image and the resolution parameter of the second original image have a second difference. The second difference is different from the first difference. The first original image and the second original image are two frames in a plurality of consecutively acquired original images.

Abstract: A sample preparation mould and a sample preparation method for the triaxial test of MSW are provided. In the present invention, the cylindrical main mould comprises two curved steel pieces, and the two sides of each curved steel piece have a stretched connection part; the two curved steel pieces are connected with each other and clamped by two steel clamps; porous stones are arranged at two ends of the cylindrical main mould and fixed separately by a top limiting lantern ring and a bottom lantern ring; the top limiting lantern ring is detachably connected to the top hopper, from which MSW materials are input; the cylindrical main mould is radially constrained in four positions, and the two ends thereof are axially constrained, thereby significantly improving stability during compacting and hence ensuring the axial and radial sizes of the MSW sample.

Abstract: The present invention relates to an equipment for enabling and accelerating uniform reaction between a to-be-reacted substance contained in a porous substrate and a reactant, and the equipment comprises: a machine body having a draining bottom plate on which the porous substrate can be placed; and a coating head which is provided above the machine body, can be moved horizontally along the porous substrate while maintaining a predetermined height, and has one or more slits, wherein each slit has an injection opening at one end and a liquid output opening at the other end.

Abstract: The present invention provides a method for enhancement of the uniform reaction on the porous materials. Comparing with the conventional Western blotting method, the present invention is successfully demonstrated capability on increasing the immune-detection signal intensity and only needs one order of magnitude less of the processing time by applying two orders of magnitude less dosage usage-amount compared to those operated in the conventional method.

Abstract: The present disclosure provides a data processing method. The data processing method includes acquiring a first original image and performing a first processing on the first original image to obtain a first processed image, a resolution parameter of the first processed image and the resolution parameter of the first original image having a first difference; and acquiring a second original image and performing a second processing on the second original image to obtain a second processed image. The resolution parameter of the second processed image and the resolution parameter of the second original image have a second difference. The second difference is different from the first difference. The first original image and the second original image are two frames in a plurality of consecutively acquired original images.

Abstract: The present invention provides a method for enhancement of the uniform reaction on the porous materials. Comparing with the conventional Western blotting method, the present invention is successfully demonstrated capability on increasing the immune-detection signal intensity and only needs one order of magnitude less of the processing time by applying two orders of magnitude less dosage usage-amount compared to those operated in the conventional method.

Abstract: A glasses frame structure includes a chassis, a pair of temples, a pair of hinges, and a plurality of fasteners. The chassis has a pair of front rims and a pair of side rims respectivey next to the front rims. Each of the side rims of the chassis can receive a first side lens. Each temple has a rimmed portion adjacent to one of the side rims of the chassis. The rimmed portion of each of the temples can receive a second side lens. The hinges can pivotally connect the temples to the chassis. Some of the fasteners can fix the hinges and the first side lenses to the chassis, while some of the fasteners can fix the hinges and the second side lenses to the temples. With the glass frame structure, the side lenses can be installed more easily and firmly.

Abstract: A coating module is suitable to coat a liquid onto a substrate and includes two plates and a diversion structure, in which there is a slot between the plates, and the slot has a slot inlet and a slot outlet, and one of the plates has an injecting port. The diversion structure makes the injecting port communicated with the slot inlet, in which the liquid is configured to enter the diversion structure via the injecting port, and flow to the slot inlet through the diversion structure, then flow into the slot via the slot inlet and then outflows from the slot via the slot outlet to be coated onto the substrate.