Abstract: Provided are a new drug candidate discovery system and a computer program implementing a new drug candidate discovery platform. A new drug candidate discovery system may include an automatic data preprocessing module configured to receive a target protein information from a user through a web interface, and perform preprocessing on a protein structure file obtained based on the target protein information; a simulation setting module configured to predict an Enzymatically Active Pocket for Docking Calculation (EAPDC) from the protein structure file using an artificial intelligence language model, and determine a docking calculation site; and a docking simulation module configured to perform a docking simulation for the docking calculation site.

Abstract: Techniques for improving the performance of an autonomous vehicle (AV) by automatically annotating objects surrounding the AV are described herein. A system can obtain sensor data from a sensor coupled to the AV and generate an initial object trajectory for an object using the sensor data. Additionally, the system can determine a fixed value for the object size of the object based on the initial object trajectory. Moreover, the system can generate an updated initial object trajectory, wherein the object size corresponds to the fixed value. Furthermore, the system can determine, based on the sensor data and the updated initial object trajectory, a refined object trajectory. Subsequently, the system can generate a multi-dimensional label for the object based on the refined object trajectory. A motion plan for controlling the AV can be generated based on the multi-dimensional label.

Abstract: The present invention relates to the technical field of hydrogen fuel power generation, specifically a hydrogen fuel high-speed rotating magnetohydrodynamic power generation device. The device comprises a shaft portion, a cover plate portion, a thin plate portion and a combustion propelling portion. The device craftily utilizes hydrogen electrochemical reaction and direct combustion of unionized hydrogen to complete the hydrogen catalytic ionization reaction while providing jet thrust for rotation. Advantages are that it is more efficient than hydrogen fuel cells, has high power density, which is suitable for high-power and high-energy power needs, utilizes no key special components and does not require auxiliary systems such as heat dissipation, breaking limitations of proton exchange membrane on hydrogen fuel cells and low efficiency of a Carnot cycle on hydrogen internal combustion engines.

Abstract: A method for prepring a porous aerogel scaffold includes: adding a photoinitiator and polyethylene glycol diacrylate in a buffer solution, dissolving by heating and evenly mixing, adding Pluronic F127 into the mixed solution, and standing at a low temperature to obtain an aerogel scaffold material; printing a hydrogel scaffold by using a 3D printing technology, and performing UV irradiation so that a cross-linking of the hydrogel scaffold is caused to form a three-dimensional scaffold with a stable structure, performing low-temperature soaking to remove Pluronic F127, and then freeze drying the three-dimensional scaffold to obtain the porous aerogel scaffold. Wherein, Pluronic F127 serves as a sacrificial material which is removed after the 3D printing of the hydrogel scaffold is completed, and then a porous structure can be formed in the scaffold in combination with a freeze drying technology, which facilitates the survival, growth and proliferation of cells during the three-dimensional culture.

Abstract: A glass composition can include from 60 mol % to 69 mol % SiO2, from 10 mol % to 18 mol % Al2O3, from 2.3 mol % to 6.9 mol % Li2O, from 2.1 mol % to 6.7 mol % Na2O, and from 1.1 mol % to 9 mol % alkaline earth metal oxides. The glass composition can comprise a liquidus viscosity greater than or equal to 150 kP. The glass composition can include from 0.25 mol % to 1 mol % K2O, from 0.5 mol % to 4 mol % P2O5, and/or 0.5 mol % to 3.6 mol % B2O3. The glass composition can form anorthoclase or a feldspar solid solution. The glass composition can include MgO+Li2O?(CaO+SrO+Na2O+K2O) is from ?0.5 to ?4. The glass composition can include volume electrical resistivity is greater than or equal to 2×1015 Ohm-centimeters. The glass composition may have a fracture toughness of greater than or equal 0.75 MPa?m.

Abstract: A wake-up method and apparatus for a smart device, a storage medium and an electronic device are provided. The method includes: selecting, from a plurality of smart devices, at least one smart device that is allowed to be awakened by a wake-up signal as at least one candidate device; when there are multiple candidate devices, determining a target wake-up angle and target wake-up energy corresponding to each of the multiple candidate devices; and determining a target device from the multiple candidate devices according to the target wake-up angle and the target wake-up energy, wherein the target device is used for responding to the wake-up signal.

Abstract: The present invention belongs to the field of biomedicine, which discloses a class of lipid compounds containing carbamate bond and applications thereof. The lipid compounds have the following structures: wherein the definitions of the various groups are described in the specification. The lipid nanoparticulate carriers prepared from the compounds described in the present invention exhibit excellent biocompatibility and safety as well as unexpected improvements in transfection efficiency, making them suitable for biomedical industrialization.

Abstract: The disclosure provides methods and electronic device for information processing. The method of applies to a terminal using a first communication protocol for information comprises: The method generates rendering information corresponding to the display storage buffer on the terminal, based on a pre-requested display storage buffer of a server. The method further generates through an application backend based on an extension protocol of the first communication protocol, submission information containing texture information for generating a display image according to the rendering information and the display storage buffer.

Abstract: A refrigerator with a reserved installation space arranged in a bottom heat dissipation compartment includes a cabinet with a heat dissipation compartment set at its rear bottom; a compressor, a duct assembly, and an evaporating tray sequentially arranged within the heat dissipation compartment along a horizontal direction of the cabinet, and the heat dissipation compartment reserves an installation space on one side away from the duct assembly relative to the evaporating tray, the installation space is equipped with one or more mating structures, each of which is used to install an auxiliary functional component. This design optimizes the layout of devices within the confined space of the heat dissipation compartment to fulfill the purpose of reserving installation space. This provides installation space for expanding the functionality of different refrigerator models, enhancing product competitiveness and saving development costs.

Abstract: A server includes a server module and an expansion module, the server module includes a first tray provided with a first connecting mechanism, a first circuit board mounted on the first tray, and a top cover covered on the first tray for enclosing the first circuit board between the first tray and the top cover; the expansion module includes a second tray provided with a second connecting mechanism matching with the first connecting mechanism and a second circuit board mounted on the second tray, the second circuit board is electrically connected to the first circuit board. A server system is also provided.

Abstract: The present disclosure relates to methods of treating a cellular proliferative disorder (e.g., cancer) comprising administering: (a) an anti-human PD-1 antibody or antigen binding fragment thereof; and (b) an Immunoconjugate of Formula (I): wherein: Ab is an antibody that binds to Trop-2; and n is an integer from 1 to 10. Also disclosed are therapeutic combinations and kits containing such agents for the treatment of cancers.

Abstract: This disclosure provides wireless communication methods, components, devices and systems for applying spectral masks and spectral flatness parameters in conjunction with transmission of millimeter wave (mmWave) signals in wireless communication networks. In some examples, in conjunction with transmission of an mmWave signal, a wireless communication device can apply a derivative spectral mask featuring transitional offset ranges that correspond to transitional frequency offset ranges of a spectral mask for a nominal carrier signal, scaled according to a ratio between a bandwidth of the mmWave signal and a bandwidth of the nominal carrier signal. In some examples, the derivative spectral mask can feature an in-band frequency offset range that is wider than a scaled width of an in-band frequency offset range of the spectral mask for the nominal carrier signal.

Abstract: A compound comprising a ligand LA, having a structure of Formula I, is provided. In Formula I, A1 to A8 are each independently CR or N; at least two adjacent ones of A1 to A8 are CR and the Rs are joined together to form a six-membered ring fused to ring A or ring C; X is O, S, or Se; each R and RB is independently hydrogen or a substituent; any adjacent substituents are optionally joined or fused into a ring; the ligand LA is coordinated to a metal M; the metal M is bonded to ring A through a M-C bond; the metal M can be coordinated to other ligands; and the ligand LA is optionally linked with other ligands. Formulations, OLEDs, and consumer products containing such compounds are also disclosed.

Abstract: This disclosure provides methods, devices and systems for increasing the transmit power of wireless communication devices operating on power spectral density (PSD)-limited wireless channels. Some implementations more specifically relate to LTF designs that support distributed transmissions. In some aspects, a transmitting device may obtain a sequence of values representing an LTF of a PPDU and may map the sequence of values to a number (N) of noncontiguous subcarrier indices of a plurality of subcarrier indices spanning a wireless channel according to a distributed tone plan. In some implementations, the transmitting device may modulate the sequence of values on N tones, representing a logical RU, and map the N tones to the N noncontiguous subcarrier indices, respectively. In some other implementations, the sequence of values may be obtained based on relative locations of the N noncontiguous subcarrier indices in the wireless channel.

Abstract: The present invention provides a lipid nanoparticle (LNP) formulation comprising at least one sialic acid (SA)-containing lipid. The LNP formulation is capable of effectively binding cell surface Siglecs, transfecting certain cells in vitro and targeting certain cells in vivo. The present invention also provides methods of using the LNP compositions described herein for pharmaceutical applications. For example, the LNPs provided herein are useful for the intracellular delivery of a nucleic acid therapeutic to a subject.

Abstract: Methods and systems for monitoring an alternator are disclosed. A method of monitoring an alternator comprises: receiving alternator output data indicating an electrical output of an alternator; estimating an expected excitation current in a rotor of the alternator from the alternator output data; estimating an equivalent open circuit voltage of the alternator from the expected excitation current estimated; plotting a characteristic test curve for the alternator using the estimated equivalent open circuit voltage and the measured excitation current in the rotor of the alternator; and assessing a condition of the rotor of the alternator using the characteristic test curve.

Abstract: Techniques for generating and presenting search filter recommendations are disclosed. A system determines a composition of search filter tiles, including a relative number of machine learning-generated search filter tiles and non-machine learning-generated search filter tiles, based on recommendation criteria. The recommendation criteria include an amount of user search history data that exists. The system applies search filter recommendation policies to generate a set of search filter recommendations, including hard-coded search filters, search filter recommendations generated by a user-specific machine learning model, search filter recommendations generated by a machine learning model trained on data from multiple different users, and algorithm-based recommendations. The system generates different sets of search filter recommendations made up of different ratios of recommendations from different sources based on determining if search filter criteria are met.

Abstract: A composite includes a substrate and a target material, wherein the target material includes indium oxide (In2O3), tin oxide (SnO2), and gallium oxide (Ga2O3), and a method for making the same. The method includes positioning the substrate and a target in a chamber and applying radio frequency (RF) power to the chamber to sputter ions of target material from the target onto the substrate.

Abstract: A suspension for a vehicle may include: a main frame; a lower leaf spring installed on either side of the main frame; an upper leaf spring disposed above the lower leaf spring so as to be spaced apart from the lower leaf spring; a connection bracket supported by the upper leaf spring, and rotatably mounted on the main frame; an eye clip mounted on an end portion of the lower leaf spring, and connected to a wheel; and a rubber bush mounted on either side of the upper leaf spring, and connected to a vehicle body.

Abstract: The present invention enables accelerated feature vector crafting with a high level of trustworthiness. Heretofore, a system (10) is set up from a data source verification apparatus (12) for verifying the at least one data source (14-1, . . . , 14-n) that generates the new specimen data and a feature vector crafting apparatus (18) for crafting at least one new feature vector from the new specimen data. The feature vector crafting apparatus (18) receiving data after verification of data sources (14-1, . . . , 14-n). The feature vector crafting apparatus (18) automatically generates new feature vectors from new data for forwarding there to an artificial intelligence infrastructure (20).