Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: The present invention relates to a metal oxide nanoparticle ink composition, a method of producing the same, and a method of forming a conductive layer pattern by using the metal oxide nanoparticle ink composition, and more particularly, to a metal oxide nanoparticle ink composition for forming a conductive layer by irradiating an ink composition thin film containing nickel oxide nanoparticles with a sintering laser, a method of producing the same, and a method of forming a conductive layer pattern by using the metal oxide nanoparticle ink composition.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: The present invention relates to a metal oxide nanoparticle ink composition, a method of producing the same, and a method of forming a conductive layer pattern by using the metal oxide nanoparticle ink composition, and more particularly, to a metal oxide nanoparticle ink composition for forming a conductive layer by irradiating an ink composition thin film containing nickel oxide nanoparticles with a sintering laser, a method of producing the same, and a method of forming a conductive layer pattern by using the metal oxide nanoparticle ink composition.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

Abstract: In a bilateral bite block, a broad upper component extends bilaterally between a front end and a back end for overlying a person's tongue and at least some of the person's lower molars and for underlying at least some of the person's upper molars. Molar blocks extend downward from both sides of the broad upper component and are disposed for contacting the person's lower molars. A groove is disposed within a top surface of a handle and the broad upper component for receiving an endotracheal tube. An aperture is disposed within the groove in the broad upper component for grasping a received endotracheal tube that can extend within the groove from the handle to beyond the back end of the upper component so that a received endotracheal tube that extends within the groove can contact the person's tongue and thereby enhance the grasp of the endotracheal tube.

Abstract: Apparatus that allows at least one feature of a patient's face to be observed while the patient is in a prone position includes a facial cushion, a video camera and a monitor. The facial cushion provides cranial support for a patient in a prone position during a medical procedure. The cushion has a frontal aperture that is dimensioned so that the facial feature of a patient wearing the facial cushion and in a prone position are visible through the at least one aperture. The video camera has a lens disposed for providing a sequence of video signals representing sequential images of the facial features that are visible through the frontal aperture. The monitor is coupled to the video camera for enabling the images of the at least one facial feature to be monitored. The images are monitored by a video monitor and/or a computer.

Abstract: Apparatus that allows at least one feature of a patient's face to be observed while the patient is in a prone position includes a facial cushion, a video camera and a monitor. A self supporting facial cushion provides cranial support for a patient in a prone position during a medical procedure. The cushion has a frontal aperture that is dimensioned so that the facial feature of a patient wearing the facial cushion and in a prone position are visible through the at least one aperture. A portion of the facial cushion that contacts a supporting surface when the facial cushion is self supported defines a tunnel through which at least the lens of the video camera can be inserted for movement from outside the facial cushion to a position beneath the patient's face.

Abstract: Apparatus for supporting a person's head in a selected position includes a flexible shaft that will maintain its shape when reconfigured for enabling a person's head to be supported in a selected position and a first coupler attached to one end of the shaft for coupling a replaceable chinrest to the one end of the shaft in a releasable restraining engagement. The first coupler includes a protuberance that is shaped for fitting within a cavity of the replaceable chinrest. The first coupler is rotatable about the longitudinal axis of the shaft. A second coupler is attached to the other end of the shaft for coupling a replaceable support base to the other end of the shaft in a releasable restraining engagement. The second coupler includes a protuberance having a shape that is functionally equivalent to the shape of the protuberance of the first coupler.

Abstract: A protective eye guard includes a flexible facial mask, a pair of eye covers, a sponge-like material and a layer of shielding material. The facial mask is configured and sized to overlay the portion of a patient's face surrounding the eyes and has a pair of openings overlying the eyes. The eye covers overlie the openings in the facial mask. Within the openings, a pair of enclosed chambers overlying the patient's eyes are defined beneath the respective eye covers. The sponge-like material is disposed in each chamber for absorbing a liquid that disperses and absorbs the energy of a laser beam. The layer of shielding material is an aluminum foil, which is disposed beneath the sponge-like material and overlies the openings for shielding the patient's eyes from the liquid and for also further shielding the patient's eyes from said laser beam.

Abstract: Apparatus that allows at least one feature of a patient's face to be observed while the patient is in a prone position includes a facial cushion, a video camera and a monitor. The facial cushion provides cranial support for a patient in a prone position during a medical procedure. The cushion has a frontal aperture that is dimensioned so that the facial feature of a patient wearing the facial cushion and in a prone position are visible through the at least one aperture. The video camera has a lens disposed for providing a sequence of video signals representing sequential images of the facial features that are visible through the frontal aperture. The monitor is coupled to the video camera for enabling the images of the at least one facial feature to be monitored. The images are monitored by a video monitor and/or a computer.

Abstract: There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.

Abstract: There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.

Abstract: Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.

Abstract: There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.

Abstract: The method of the invention for extracting electrons in a vacuum consists in: making a cathode presenting at least one junction (9) between a metal (7) acting as an electron reservoir and an n-type semiconductor (8) possessing a surface potential barrier with a height of a few tenths of an electron volt, and presenting thickness lying in the range 1 nm to 20 nm; injecting electrons through the metal/semiconductor junction (9) to create a space charge in the semiconductor (8) sufficient to lower the surface potential barrier of the semiconductor to a value that is less than or equal to 1 eV relative to the Fermi level of the metal (7); and using the bias source creating an electric field in the vacuum to control the height of the surface potential barrier (Vp) of the n-type semiconductor in order to control the emission of the electron flux towards the anode.

Abstract: and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.