Abstract: A system may include a bottom layer and a sensing layer disposed on a first side of the bottom layer. The first sensing layer may include a first sensing element and a second sensing element. The first sensing element and the second sensing element may include one of: a force sensing element, a strain sensing element, a motion sensing element, or an environmental sensing element. The first sensing element and the second sensing element may be of a different type of sensing element. The system may also include a communications interface configured to couple the sensing layer with a host controller.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: Provided is yarn for a cell culture scaffold. The yarn for a cell culture scaffold according to an exemplary embodiment of the present invention includes slitting yarn produced by cutting a compressed nanofiber web to a predetermined width. Accordingly, by creating microenvironments suitable for migration, proliferation and differentiation of cells, cell viability may be enhanced and cells may be three-dimensionally proliferated. In addition, a scaffold according to the present invention has a mechanical strength sufficient for prevention of disruption of the scaffold which occurs during cell culture, such that cells may be stably proliferated. Further, the scaffold according to the present invention uses slitting yarn formed of the compressed nanofiber web, thereby having pores with various sizes, and therefore cell proliferation and cell viability may be enhanced by creation of an extracellular matrix-like environment.

Abstract: According to various embodiments, a wearable device may be provided. The wearable device may include: a display panel having integrally formed a first display portion and a second display portion; and a driver circuit configured to control the first display portion with a first frequency and to control the second display portion with a second frequency.

Abstract: The present disclosure is broadly concerned with the field of cancer immunotherapy. For example, the present disclosure generally related to a binding molecule comprising antibody variable light (VL) regions, variable heavy (VH) regions, constant heavy 1 (CH1) regions, and light chain constant (CL) regions that are configured to form two antigen binding Fab regions and an antigen binding Fv region so that the binding molecule binds to two different antigens.

Abstract: A method for preventing or treating hyperlipidemia includes administrating a composition consisting of a Salvia miltiorrhiza extract, a Crataegus pinnatifida extract, a Polygonum multiflorum extract, and a Ligusticum chuanxiong extract to a subject in need thereof. The composition may reduce an amounts of serum cholesterol and LDL-cholesterol and increase an amount of HDL-cholesterol, significantly reduce an amount of serum triglyceride compared with existing statin-based drugs, thereby exhibiting prophylactic and therapeutic effects of hyperlipidemia with various symptoms even without the co-administration of other drugs; and reduce an amounts of hepatic cholesterol and triglyceride, thereby exhibiting an effect of inhibiting fatty liver.

Abstract: Fabricating a layer including lithium lanthanum zirconate (Li7La3Zr2O12) layer includes forming a slurry including lanthanum zirconate (La2Zr2O7) nanocrystals, a lithium precursor, and a lanthanum precursor in stoichiometric amounts to yield a dispersion including lithium, lanthanum, and zirconium. In some cases, the dispersion includes lithium, lanthanum, and zirconium in a molar ratio of 7:3:2. In certain cases, the slurry includes excess lithium. The slurry is dispensed onto a substrate and dried. The dried slurry is calcined to yield the layer including lithium lanthanum zirconate.

Abstract: A method includes receiving, at a network control component, an enhanced subscriber profile identifier (E-SPID) associated with at least one machine type communications (MTC) user device from a home subscriber server (HSS). The method includes determining whether the E-SPID is in a first range of E-SPID values, wherein the first range of E-SPID values corresponds to a delay that exceeds a threshold, and interacting with a self-organizing network (SON) controller that interacts an operation administration maintenance (OAM) component to control and define a modified E-SPID based on network traffic and coverage in response to a determination that the E-SPID is in the first range of E-SPID values. The method further includes sending the modified E-SPID to at least one enhanced evolved node b (eNodeB) associated with the at least one MTC user device, wherein the at least one enhanced eNodeB is operable to perform access control and scheduling for the at least one MTC user device based on the E-SPID.

Abstract: A network-based service is disclosed for disambiguating search queries based on a location-based clustering of search results corresponding to the query. In one embodiment, a user may submit a query for travel items, such as hotel accommodations. The service can determine, based on the query, an initial set of hotels providing such accommodations. The service can then cluster the hotels according to their geographic positions. If the service identifies multiple clusters, the user can be prompted to select a specific cluster to receive additional information regarding the cluster. Illustratively, if a user submits a query for a hotel in “Springfield,” the service may ask the user to select among multiple clusters of results, each corresponding to a different city named “Springfield” in which results have been located.

Abstract: An electronic device including a waterproof structure is provided. The electronic device includes a housing that includes a first face, a second face that faces in a direction substantially opposite to the first face, and a side surface that at least partially encloses a space between the first face and the second face, a middle plate arranged between the first face and the second face inside the housing to be substantially parallel to the first face, extending from the side surface, and including at least one opening, a printed circuit board arranged between the middle plate and the second face, a display arranged between the middle plate and the first face, and including a face directed toward the second face, and a seal member configured to hermetically seal the at least one opening of the middle plate, and arranged between the face of the display and the middle plate.

Abstract: The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising a histone H3 peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

Abstract: A method of manufacturing a package, comprising embedding the semiconductor chip with an encapsulant comprising a transition metal in a concentration in a range between 10 ppm and 10,000 ppm; selectively converting of a part of the transition metal, such that the electrical conductivity of the encapsulant increases; and plating the converted part of the encapsulant with an electrically conductive material.

Abstract: A method of forming a protective film on at least one electronic module is provided. The method includes the following steps. A protective material is disposed on at least one electronic module such that the protective material and the electronic modules are in contact with each other. The electronic modules and the protective material disposed on the electronic modules are disposed in a chamber, and a first ambient pressure is provided in the chamber. The protective material in the chamber is heated to a first temperature to soften the protective material disposed on the electronic modules. After the protective material is softened, a second ambient pressure greater than the first ambient pressure is provided in the chamber, wherein a gas in the chamber directly pressurizes the protective material such that the protective material conformally covers a top of the electronic modules.

Abstract: Provided are a hexuronate C4-epimerase variant with improved activity in converting D-fructose by D-tagatose of hexuronate C4-epimerase and a method for production of D-tagatose using them.

Abstract: A battery module according to the present disclosure includes a first busbar electrically connected to a first electrode lead of a first battery cell, a second busbar electrically connected to a second electrode lead of a second battery cell, a short part which moves to the first busbar and the second busbar and comes into contact with the first busbar and the second busbar by the application of an expansion force caused by volume increase of the first battery cell to electrically connect the first busbar to the second busbar, causing a short, and a cartridge which receives or supports at least part of the first electrode lead, the second electrode lead, the first busbar, the second busbar and the short part.

Abstract: Disclosed are product (e.g., panels), slurry, and methods relating to a pregelatinized starch having a mid-range viscosity (i.e., from about 20 centipoise to about 700 centipoise), and an extruded pregelatinized starch.

Abstract: The present disclosure provides a mobile App to provide a runtime environment on a mobile device. As part of start up processing, the mobile App can receive a resource bundle that contains an entry point application module and one or more resource modules. In some embodiments, the resource bundle contains no resource modules. The mobile App can load the entry point application module without loading the resource modules into the runtime environment, and start code execution. When a request for a resource module is encountered during code execution, the mobile App can access the requested resource module and load it into the runtime environment.

Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.