Abstract: Apparatus and method of managing genomic sequencing data. In an embodiment, a data management controller is communicatively coupled to an external data repository over a communication network. The data management controller is configured to detect a first event triggering initial analysis on raw sequence data encoded in a standard file format and stored in the external data repository. The data management controller is configured to launch one or more analysis tools to perform the initial analysis on the raw sequence data stored in the external data repository, and to output initial analysis results. The data management controller is configured to determine whether the initial analysis results pass quality control, and control electronic storage of the raw sequence data when the initial analysis results pass quality control by storing the raw sequence data in archive storage, and deleting the raw sequence data from the external data repository.

Abstract: The invention relates to peptides, proteins, nucleic acids, and cells for use in immunotherapeutic methods. In particular, the invention relates to the immunotherapy of cancer. The invention provides T cell receptors (TCRs), tumor infiltrating lymphocytes (TILs), and vaccines that recognize HERV-K. The invention provides TCR sequences generated from tumor infiltrating lymphocytes that recognize HERV-K antigens as peptides bound to the Major Histocompatibility Complex (MHC), resulting in an interaction between the HLA-peptide complex and the CDS TCR. Peptides bound to molecules of the MHC, or peptides as such, can also be targets of antibodies, soluble TCRs, and other binding molecules.

Abstract: A simple shear assembly includes: a base plate detachably mounted on a loading platform, and a stacked ring group opposite to the base plate; wherein the stacked ring group comprises: a plurality of stacked rings capable of sliding relative to each other; each of the stacked rings comprises a mounting frame and a holding frame provided within the mounting frame; the mounting frame comprises a support portion and a protective portion fixed to a top part of the support portion; the protective portion comprises a limiting groove and a rolling surface provided in the limiting groove; a support portion of an above adjacent stacked ring is rolled and supported on the rolling surface, in such a manner that all the stacked rings freely stagger with each other to perform interface simple shear. The protective portion can prevent the stacked rings from overturning.

Abstract: A display substrate comprises a display region comprising a first display sub-region and a second display sub-region adjoining the first display sub-region, a plurality of first-type sub-pixels located in the first display sub-region that are divided into sub-pixel groups, each sub-pixel group comprising at least two adjacent first-type sub-pixels in a row direction, each first-type sub-pixel comprising a light-emitting element and a pixel circuit configured to drive the light emitting element to emit light; and a plurality of power lines connected to the first-type sub-pixels. The power lines comprise first-type and second-type power lines. The first-type power lines extend in the row direction and are connected to pixel circuits of the first-type sub-pixels in the row direction, and the second-type power lines extend in a column direction and are connected to pixel circuits of the first-type sub-pixels in the column direction. The row direction and the column direction intersect.

Abstract: A FinFET LDMOS device includes a semiconductor substrate; juxtaposed first well and second well in the semiconductor substrate; semiconductor fins extending on the semiconductor substrate along a first direction, the semiconductor fins including a first fin portion in the first well and a second fin portion in the second well; an extra semiconductor body adjoining the first fin portion and the second fin portion and extending along a second direction; a source region on the first fin portion; a drain region on the second fin portion; a gate covering the semiconductor fin and extending along the second direction, wherein the gate partially overlaps the first fin portion and partially overlaps the second fin portion, and the extra semiconductor body is covered by the gate; and a single-diffusion break structure embedded in the second fin portion and between the gate and drain region.

Abstract: A light emitting diode (LED) pixel array and method of fabrication thereof. A semiconductor wafer template includes a successively stacked first n-GaN layer, first MQW layer, p-GaN layer, and dielectric layer. A plurality of apertures is formed through the dielectric layer, extending to the p-GaN layer. A plurality of mesas is formed by forming, within each aperture, a second MQW layer and a second n-GaN layer above each second MQW layer. The second n-GaN layer and second MQW layer of each mesa form a respective mesa LED with the p-GaN layer. The first n-GaN layer and first MQW layer form a lower LED with the p-GaN layer.

Abstract: A control method for an electric heating appliance having a first switch module, a second switch module, and a load, a control terminal of the first switch module being accessing a target pulse width modulation (PWM) signal, an output terminal of the first switch module being connected to a control terminal of the second switch module, an input terminal of the second switch module accessing a power supply voltage, an output terminal of the second switch module being connected to the load, and an output signal of the first switch module controlling the second switch module to be in an on state or an off state, includes: determining a first PWM signal, the first PWM signal being a signal loaded onto the control terminal of the first switch module in a state in which the first switch module operates independently, so as to drive the first switch module.

Abstract: There is provided mechanisms for operating a DPD for a non-linear electronic device. A method is performed by a DPD controller. The method comprises receiving an input signal destined to be input to the non-linear electronic device. The method comprises selecting a basis function that represent non-linear input-output characteristics of the non-linear electronic device. The basis function is defined by kernels of a pruned Volterra series, and comprises higher-than-order-1 polynomial terms, polynomial cross-terms, memory cross-terms, and common tap delays shared by all polynomial terms. The method comprises obtaining an output signal by subjecting the input signal to a linearization function defined by the basis function. The method comprises providing the output signal as input to the non-linear electronic device.

Abstract: Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least one Myristica extract, at least one Astragalus extract, and at least one Poria extract.

Abstract: An oscillating tool includes a housing; a motor in the housing; a first blade clamp; a blade clamp shaft; and a second blade clamp on the blade clamp shaft. The blade clamp shaft includes a latching portion to engage a seat. The oscillating tool also includes a blade clamp spring configured to bias the latching portion into engagement with the seat.

Abstract: A manufacturing method for an array substrate, an array substrate, and a display apparatus. The manufacturing method comprises: step S100, providing a base substrate; step S200, forming a driving circuit layer on one side of the base substrate the driving circuit layer comprising a plurality of wires and a plurality of bonding pads; step S300, forming a removable protective layer on the side of the driving circuit layer away from the base substrate; and step S400, connecting functional devices to the bonding pads, the removable protective layer being decomposed and removed in step S400. Between step S200 and step S300, there are no steps of forming an inorganic protective layer and patterning the inorganic protective layer.

Abstract: An electronic device includes: a substrate including a through hole; a connecting element disposed in the through hole; a first insulating layer disposed on the substrate and including a first via; a first conductive element disposed on the first insulating layer and electrically connected to the connecting element through the first via; a second conductive element disposed under the substrate and electrically connected to the connecting element; and a semiconductor disposed between the substrate and the first insulating layer.

Abstract: A method of forming an integrated circuit structure includes forming a patterned passivation layer over a metal pad, with a top surface of the metal pad revealed through a first opening in the patterned passivation layer, and applying a polymer layer over the patterned passivation layer. The polymer layer is substantially free from N-Methyl-2-pyrrolidone (NMP), and comprises aliphatic amide as a solvent. The method further includes performing a light-exposure process on the polymer layer, performing a development process on the polymer layer to form a second opening in the polymer layer, wherein the top surface of the metal pad is revealed to the second opening, baking the polymer, and forming a conductive region having a via portion extending into the second opening.

Abstract: This application provides a communication method and apparatus. The method includes: A terminal device receives a wake-up signal from a network device, where the wake-up signal includes a first identifier; and when the first identifier is an identifier of the terminal device, the terminal device receives paging-related information based on a length of the first identifier or initiates random access based on a length of the first identifier. In the technical solutions provided in this application, the terminal device may receive the paging-related information or initiate random access based on the length of the identifier of the terminal device in the wake-up signal, to reduce power consumption.

Abstract: Provided is an array substrate. The array substrate includes a base substrate, a gate line, a data line, a discharge line, a first pixel electrode, a first thin film transistor, a second thin film transistor and a first connection line. A control electrode of the first thin film transistor and a control electrode of the second thin film transistor are both connected to the gate line. The first electrode of the first thin film transistor is connected to the data line. Both the second electrode of the first thin film transistor and the first electrode of the second thin film transistor are connected to the first pixel electrode by the first connection line. The second electrode of the second thin film transistor is connected to the discharge line.

Abstract: The invention is directed to compositions and processes concerning efficient downstream processing of products derived from organic acids pretreatment of plant materials.

Abstract: A method for controlling a movable object includes determining, based on current location information of an obstacle, whether the obstacle is located within a certain distance range from the movable object, and in response to determining that the obstacle is located within the certain distance range from the movable object: determining, based on the current location information of the obstacle, whether the obstacle meets a first distance criterion or a second distance criterion, to obtain a determination result, and performing a first adjustment or a second adjustment on one or more movement characteristics of the movable object based on the determination result. The first adjustment is different from the second adjustment. One of the first adjustment and the second adjustment includes changing a movement direction of the movable object from a first direction to a second direction. The first direction is opposite to the second direction.

Abstract: The present disclosure provides an antenna and a temperature control system of the antenna. The antenna includes a feed unit layer, a phase shifter layer, an amplifying circuit disposed between the feed unit layer and the phase shifter layer, and a temperature control unit disposed on a side of the amplifying circuit. The amplifying circuit is configured to amplify a microwave signal fed from the feed unit layer and transmit the microwave signal to the phase shifter layer; the phase shifter layer is configured to shift a phase of the microwave signal by a preset phase shift amount; and the temperature control unit is configured to adjust a temperature of the amplifying circuit to adjust an operating temperature of the antenna. The temperature control unit is in direct contact with the amplifying circuit.

Abstract: Provided is a sulfonamide derivate represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing said derivative, and the use thereof as a therapeutic agent, especially as a Lysine Acetyl Transferase (KAT) inhibitor and the use of same in the preparation of a medicament for the treatment and/or prevention of cancer.

Abstract: The present disclosure provides a filter, an adapter, and a microvolume ultrafiltration bottle. The filter comprises a tubular structure that penetrates vertically. The inner wall of the tubular structure gradually converges from top to bottom towards the centerline to form an inverted tapered inner cavity structure, with a tapered hole at the bottom of the inverted tapered inner cavity structure. A filter disc connection part is arranged at the lower end of the tubular structure, and a bottom flow guiding channel or bottom flow guiding zone is arranged between the tapered hole and the filter disc connection part. The inner wall of the lower end of the adapter is connected with the filter. The microvolume ultrafiltration bottle comprises a bottle body and the adapter arranged at the bottle mouth and extending downwards into the bottle body, with the filter connected with the bottom of the adapter.