Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: A method for determining tobacco-specific nitrosamines (TSNAs) in cigarette smoke using one-step clean-up coupled with LC-MS/MS is provided, including the following steps: collecting a particulate matter of mainstream cigarette smoke with a Cambridge filter pad, mixing the particulate matter of mainstream cigarette smoke, an internal standards solution and water in a 50 mL plastic centrifuge tube, and vortexing the resulting mixture at room temperature to allow extraction; transferring an extraction solution after filtration to a new centrifuge tube, adding dichloromethane, and vortexing the resulting mixture; centrifuging to collect a dichloromethane extraction solution in a lower layer to another centrifuge tube, and placing the centrifuge tube in a water bath to remove dichloromethane; dissolving the resulting extraction solution in water, and transferring the resulting solution to an autosampler vial for LC-MS/MS analysis.

Abstract: An example electrostatic machine includes a number of stator plates, each having a stator electrode and rotationally fixed to a housing, a shaft at least partially defined within the housing and configured to rotate about an axis, and a number of rotor plates, each having a rotor electrode and rotational fixed to the shaft. The electrostatic machine includes a dielectric fluid disposed in the housing, and that fills a gap between the stator plates and the rotor plates. The electrostatic machine includes a seal associated with the shaft, where the seal includes a material compatible with the dielectric fluid.

Abstract: An augmented reality (AR) calibration process for an eyewear device that customizes an AR user interface (UI) for the wearer. Physiological characteristics such as arm length and hand size are determined from images captured by the eyewear device for use in adjusting the UI controls before rendering the UI.

Abstract: A data processing method and apparatus, and a related product. The data processing method comprises: when a decoded processing instruction is a vector extension instruction, determining a source data address, a destination data address and an extension parameter of data corresponding to the processing instruction; according to the extension parameter, extending first vector data of the source data address, so as to obtain extended second vector data; storing the second vector data to the destination data address, wherein the source data address and the destination data address comprise consecutive data addresses. Vector extension and storage are implemented by means of an extension parameter in a vector extension instruction, so as to obtain extended vector data, thereby simplifying processing, and reducing data overhead.

Abstract: An outdoor electric cabinet and an air duct structure thereof are provided. The air duct structure is used to guide airflow to an air inlet side of a fan. The air duct structure includes an air inlet port, a flow-guiding cavity and an air distribution assembly. The air inlet port is configured to introduce external airflow into the air duct structure. The flow-guiding cavity is formed between the air inlet port and the air inlet side of the fan. The air distribution assembly is arranged in the flow-guiding cavity to uniformly distribute an air suction force of the air inlet port. The airflow suction force at the air inlet port is distributed more uniformly by the air distribution assembly, which effectively weakens the maximum wind speed on the shortest path.

Abstract: The embodiments of the present disclosure provide an antibody or antigen-binding fragment against SARS-CoV-2 spike(S) protein, comprising: three complementarity determining regions (HCDRs) of a heavy chain variable region or one or more variants thereof, the heavy chain variable region set forth as SEQ ID NO. 30 or SEQ ID NO. 46, each of the one or more variants having at most two amino acid changes compared to the corresponding CDR; and three complementarity determining regions (LCDRs) of a light chain variable region or one or more variants thereof, the light chain variable region set forth as SEQ ID NO. 32 or SEQ ID NO. 48, each of the one or more variants having at most two amino acid changes compared to the corresponding CDR.

Abstract: The present disclosure relates to a data processing method, a data processing apparatus, and related products. The data processing apparatus includes an address determining unit and a data storage unit. The address determining unit is configured to determine a source data address and a plurality of discrete destination data addresses of data corresponding to a processing instruction when the decoded processing instruction is a discrete store instruction, where the source data address may include continuous data addresses.

Abstract: A method for detecting a topological structure of a grounding grid under extremely cold condition, includes the following steps: in a substation in an extremely cold area, determining a measuring area S on a ground surface of a grounding grid according to the positions of branches and nodes of the grounding grid in a selected area, acquiring dynamic current values of the branches and nodes through a current sensor based on TMR tunnel magnetoresistance, and then indirectly acquiring the magnetic induction intensity of the measuring area S through conversion; calculating moduli of first to third derivatives of magnetic induction intensities; and determining specific positions and laying depths of the branches of the grounding grid according to peak distances between main lobe peaks and side peaks between strong peaks of the moduli. According to the method, the calculation amount is greatly reduced, and the detection method has strong anti-interference.

Abstract: Systems and techniques are described for depth sensing. For example, a method can include obtaining a first depth image of a scene. The first depth image of the scene is associated with a first illumination configuration including illuminating the scene with a first type of illumination. The method can include obtaining a second depth image of the scene, wherein the second depth image is associated with a second illumination configuration, different from the first illumination configuration. The second illumination configuration includes illuminating the scene with a second type of illumination. The method can include determining, based on the second depth image, multipath interference (MPI) associated with the first depth image. The method can further include generating based on determining the MPI associated with the first depth image an adjusted depth image including one or more pixels from the first depth image and one or more adjusted pixels.

Abstract: A method for processing breast tissue image data includes processing the image data to generate a set of image slices collectively depicting the patient's breast; for each image slice, applying one or more filters associated with a plurality of multi-level feature modules, each configured to represent and recognize an assigned characteristic or feature of a high-dimensional object; generating at each multi-level feature module a feature map depicting regions of the image slice having the assigned feature; combining the feature maps generated from the plurality of multi-level feature modules into a combined image object map indicating a probability that the high-dimensional object is present at a particular location of the image slice; and creating a 2D synthesized image identifying one or more high-dimensional objects based at least in part on object maps generated for a plurality of image slices.

Abstract: Provided are control method and device of an energy-storage coordinated floating wind turbine, relating to the technical field of wind turbines. The control method of an energy-storage coordinated floating wind turbine can construct a primary frequency regulation model of a floating wind farm based on a frequency response unit, construct a second frequency regulation model according to an energy storage system, further construct, according to the primary frequency regulation model and the second frequency regulation model, a frequency regulation model of a hybrid power system containing the floating wind farm, the energy storage system, and a pre-set thermal power unit, and design an overall frequency regulation control strategy of the hybrid power system based on the frequency regulation model of the hybrid power system.

Abstract: Systems and methods for trajectory planning for an autonomous vehicle, may include: computing features for each of the plurality of candidate trajectories; computing scores for the features of the candidate trajectories, wherein the scores are based on parameter values associated with their corresponding final trajectories; determining, based on the computed scores, a trajectory of the candidate trajectories to be used as a warm-start trajectory for trajectory optimization and applying the warm-start trajectory to develop a final trajectory for the vehicle; and autonomously operating the autonomous vehicle in accordance with the final trajectory.

Abstract: A resource mapping method and apparatus are described that reduce resource mapping complexity. The method includes an access network device obtaining resource mapping information of at least one terminal, and sending the resource mapping information to the at least one terminal respectively. The resource mapping information indicates a resource element RE to which each of the at least one terminal performs mapping in each RMB in a first resource mapping block RMB set. An RE to which a first terminal performs mapping in each RMB in the first RMB set is determined based on a first interleaved sequence, and the first interleaved sequence is determined based on a base sequence. The first terminal is any one of the at least one terminal, and the first RMB set includes at least one RMB.

Abstract: The present invention relates to the field of elevator braking, in particular to an action state detection method and system for an elevator brake, comprising: acquiring matching pairs of brake linings in the same braking state; constructing normal record data sets based on the matching pairs; grouping the normal record data sets based on braking power corresponding to samples in the normal record data sets to determine a median of elevator running speed corresponding to the samples in each group; dividing the operating state levels of the elevator brake according to the size of the median; constructing a data training set; training a constructed network model to obtain a trained network model; acquiring the operating state levels of an elevator to be detected by the trained network model, evaluating the elevator brake according to the operating state levels, and controlling the elevator.

Abstract: A host of a storage system is coupled to multiple SSDs. Each SSD is configured with a migration cache, and each SSD corresponds to one piece of access information. The host obtains migration data information of to-be-migrated data in a source SSD, determines a target SSD, and sends a read instruction carrying information about to-be-migrated data and the target SSD to the source SSD. The source SSD reads a data block according to the read instruction from a flash memory of the source SSD into a migration cache of the target SSD. After a read instruction is completed by the SSD, the host sends a write instruction to the target SSD to instruct the target SSD to write the data block in the cache of the target SSD to a flash memory of the target SSD.

Abstract: A method for detecting an occluded image. The method includes: after an image is captured by a camera, obtaining the image as an image to be detected; inputting the image to be detected into a trained occluded-image detection model, the occluded-image detection model is trained based on original occluded images and non-occluded images by using a trained data feature augmentation network; determining whether the image to be detected is an occluded image based on the occluded-image detection model; and outputting an image detection result.

Abstract: Surface pressure measurements on rotating models are important for flow phenomenon identification, understanding flow mechanisms and model aerodynamic design. The disclosure discloses a periodic pressure field measurement system based on the superposed lifetime of pressure sensitive paint, including pressure sensitive paint, a pulse light source, a camera, a synchronizer and a computer. A lifetime superposition method is disclosed in the disclosure for measuring periodic pressure fields of pressure sensitive paint.

Abstract: A method includes obtaining at least one of application context relocation (ACR) capability information supported by an edge application server (EAS), ACR capability information supported by an edge enabler client (EEC), ACR capability information supported by an application client (AC), or ACR capability information supported by an edge enabler server (EES). The method also includes selecting ACR mode information for the AC based on the at least one of the ACR capability information supported by the EAS, the ACR capability information supported by the EEC, the ACR capability information supported by the AC, or the ACR capability information supported by the EES. The ACR mode information indicates an identifier indicating the AC and an ACR scenario selected for the AC.