Patents by Inventor An-Hsiang A. Chu

An-Hsiang A. Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycosylation reactions using phenyl(trifluoroethyl)iodonium salts
    Patent number: 9422325
    Abstract: Provided are methods for the preparation of glycosylation products, including those represented by formula I: Sugar-O—R???I comprising the step of combining R?—OH, a glycosyl sulfide glycosyl donor (“thioglycoside donor”), a hypervalent iodine alkyl-transfer activating reagent, and a base. In an embodiment, the hypervalent iodine alkyl-transfer activating reagent is (phenyl(trifluoroethyl)iodonium triflimide).
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: August 23, 2016
    Assignee: Trustees of Tufts College
    Inventors: Clay S. Bennett, An-Hsiang A. Chu
  • Stereoselective glycosylation reactions
    Patent number: 9359394
    Abstract: Disclosed is a method for selective synthesis of 1,2-cis-?-linked glycosides which does not require the use of the specialized protecting group patterns normally employed to control diastereoselectivity. Thioglycoside acceptors can be used, permitting iterative oligosaccharide synthesis. The approach eliminates the need for lengthy syntheses of monosaccharides possessing highly specialized and unconventional protecting group patterns.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: June 7, 2016
    Assignee: Trustees of Tufts College
    Inventors: Clay S. Bennett, An-Hsiang A. Chu
  • Glycosylation Reactions Using Phenyl(trifluoroethyl)iodonium Salts
    Publication number: 20150099870
    Abstract: Provided are methods for the preparation of glycosylation products, including those represented by formula I: Sugar-O—R???I comprising the step of combining R?—OH, a glycosyl sulfide glycosyl donor (“thioglycoside donor”), a hypervalent iodine alkyl-transfer activating reagent, and a base. In an embodiment, the hypervalent iodine alkyl-transfer activating reagent is (phenyl(trifluoroethyl)iodonium triflimide).
    Type: Application
    Filed: October 3, 2014
    Publication date: April 9, 2015
    Inventors: Clay S. Bennett, An-Hsiang A. Chu