Abstract: A novel acylated insulin analog is provided as well as a side chain compound that can be used to prepare the acylated insulin analog, a pharmaceutical composition thereof, a pharmaceutical use, an administration method and a preparation method. The acylated insulin analog can be used for the treatment of diabetes. It has the effect as a weekly preparation or a longer-acting insulin preparation and can be used for the treatment once a week or less frequently, increasing the compliance of diabetic patients.

Abstract: The present application provides a model gradient update method and device, for use in improving the accuracy of model training. A central server repeatedly executes a gradient update process until a stop condition is satisfied. One gradient update process comprises: receiving first gradients respectively sent by multiple nodes, the first gradients being obtained by each node using sample data to train a model to be trained of the node one or more times; obtaining a second gradient one the basis of the multiple first gradients and the probability of each node in the present gradient update process, the probability of each node in the present gradient update process being determined by an Actor-Critic network one the basis of the probability of each node in the last gradient update process; and sending the second gradient to the multiple nodes, respectively.

Abstract: The present application discloses a four-terminal resistance testing structure. A test key includes a resistor string formed by connecting two or more tested resistors in series. Two ends of each tested resistor are respectively provided with one first pad. At least one of the two first pads of each tested resistor is shared as the first pad of an adjacent tested resistor. Each tested resistor includes two force terminals and two sense terminals. The two force terminals are formed by the first pads at the two ends of the tested resistor, and each of the two sense terminals is composed of a pad located at a position adjacent to the corresponding force terminal. The present application can reduce the number of pads and thus save the area on the premise of ensuring the measurement accuracy.

Abstract: The present disclosure discloses a Lactobacillus plantarum ZUST49 and a bacterial agent, and use thereof, and belongs to the technical field of microorganisms. An aspect of the present disclosure provides a Lactobacillus plantarum ZUST49 and a bacterial agent containing the Lactobacillus plantarum ZUST49, and another aspect provides use of the Lactobacillus plantarum ZUST49 and the bacterial agent containing the Lactobacillus plantarum ZUST49. The Lactobacillus plantarum ZUST49 of the present disclosure may convert glucoraphanin into sulforaphane, especially in a human or animal intestinal environment. After an enteric probiotic preparation prepared from the strain of the present disclosure is orally taken, the Lactobacillus plantarum ZUST49 may efficiently convert the glucoraphanin into the sulforaphane in an intestinal tract, which not only solves a problem that stability of the sulforaphane cannot be improved in the prior art, but also effectively exerts a probiotic effect.

Abstract: A device and a method for measuring a rotation angle of a spherical hinge joint with a football-shaped structure are provided. The measuring device includes a driving electrode, and an induction electrode system. During measurement, the driving electrode and induction electrode system are both installed in a measured spherical hinge joint. The spherical hinge joint includes a ball socket base, and a ball head installed in the ball socket base. The driving electrode is fixed to the ball head. The induction electrode system includes multiple regular hexagonal spherical electrode plates, and one or more regular pentagonal spherical electrode plates. Five regular hexagonal spherical electrode plates are all arranged around any one regular pentagonal spherical electrode plate, respective regular hexagonal spherical electrode plates and respective regular pentagonal spherical electrode plate are assembled to form a spherical shell structure.

Abstract: Three-dimensional (3D) semiconductor devices and fabricating methods are disclosed. The semiconductor device includes an array of vertical transistors. Each vertical transistor includes a semiconductor body extending in a vertical direction, and an all-around gate structure laterally surrounding the semiconductor body. Each row of the vertical transistors in a first lateral direction share a common word line extending in the first lateral direction and comprising the all-around gate structures of the row of the vertical transistors. Adjacent rows of the vertical transistors are misaligned along a second lateral direction perpendicular with the first lateral direction. The array of vertical transistors are aligned along a third lateral direction different from the first lateral direction and the second lateral direction.

Abstract: A memory cell includes a thin film transistor over a semiconductor substrate. The thin film transistor includes a memory film contacting a word line; and an oxide semiconductor (OS) layer contacting a source line and a bit line, wherein the memory film is disposed between the OS layer and the word line; and a dielectric material separating the source line and the bit line. The dielectric material forms an interface with the OS layer. The dielectric material comprises hydrogen, and a hydrogen concentration at the interface between the dielectric material and the OS layer is no more than 3 atomic percent (at %).

Abstract: A paging indication method, apparatus, and system are provided, which relate to the field of communications technologies, to solve a problem that power consumption of UE is high because the UE blindly detects a PDCCH periodically. A specific solution includes: receiving, by UE, indication information from a network side device, where the indication information is used to indicate a detection parameter used by the UE to detect a paging message, and the detection parameter is used to determine a detection manner used by the UE to detect the paging message; and determining the detection manner based on the detection parameter. The embodiments of the present invention are applied to a process in which the UE determines a detection manner used to detect the paging message.

Abstract: An optical system and the adjusting device thereof. The optical system includes an optical device. The adjusting device is configured for adjusting a location of a center of the optical device. The adjusting device includes a first adjusting element which is movable along a first axis and is propped against the optical device, a second adjusting element which is movable along a second axis and is propped against the optical device, and a third adjusting element which is movable along a third axis and is propped against the optical device. The center of the optical device is spaced apart from where the first axis and the second axis meet and/or where the first axis and the third axis meet.

Abstract: A method for saving power is provided. The method is used in a slave device. The method includes receiving a first system power management interface (SPMI) write command from an external device via a SPMI bus when the slave device is in sleep mode. The method includes turning on a system clock in response to the first SPMI write command indicating to turn on the system clock. The method includes allowing the external device to access the slave device.

Abstract: Embodiments of the present disclosure provide a reference signal transmitting method and apparatus. The method includes: reference signal parameters are received, the reference signal parameters at least include the number P of ports of a reference signal and a modulation and coding scheme of the reference signal, and the number P of ports of the reference signal is determined according to the modulation and coding scheme; and the reference signal is received according to the reference signal parameters. The problem that in the related technologies, channel estimation is performed through demodulation reference signals, and when transmitted modulation information is demodulated on an estimated channel, there is an excessive demodulation reference signal overhead can be solved.

Abstract: Wireless communication between a base station and at least one user equipment comprises the following. Each user equipment periodically measures channel quality of communication with the base station and transmits a channel quality indicator to the base station. The base station schedules communication with the at least one user equipment based upon the periodically transmitted channel quality indicators.

Abstract: The present application relates to a modified immune effector cell, wherein the functions of a T cell antigen receptor (TCR) and major histocompatibility complexes (MHCI, MHCII) in the modified immune effector cell are inhibited in a T cell, and the modified immune effector cell comprises a chimeric antigen receptor (CAR) targeting IL13R?2. The modified immune effector cell of the present application knocks out TCR and HLA-A genes expressed by the cell while recognizing surface antigens of tumor cells, so that multiple effects of improving the anti-tumor effect of CAR-T cells, prolonging the survival time of the cells, and reducing the immune rejection response caused by allogeneic cell therapy are achieved.

Abstract: An information transmission method, a terminal, and a non-transitory computer-readable storage medium are provided. The information transmission method includes: receiving by the terminal, first information from a network side device. The first information includes a configuration of at least one subband.

Abstract: Provided are a vacuum distillation furnace, and a method for preparing high-purity copper particles. In view of the fact that high-purity copper prepared by the traditional method in the current industrial production has an unsatisfactory purity, a high impurity content, and a complicated composition, a vacuum distillation method is adopted. During the vacuum distillation method, most of valuable metals in a copper matrix are volatilized and enter into a gas phase, such that the metals are separated from the copper matrix, thereby allowing the purification of copper; and copper powder particles volatilized to a condensation plate have a smooth surface and a purity of 5 N grade or more.

Abstract: In some embodiments, the present disclosure relates to a memory device that includes gate electrode layers arranged over a substrate. A first memory cell is arranged over the substrate and includes first and second source/drain conductive lines that extend through the gate electrode layers. A barrier structure is arranged between the first and second source/drain conductive lines. A channel layer is arranged on outermost sidewalls of the first and second source/drain conductive lines. A first dielectric layer is arranged between the barrier structure and the channel layer. A memory layer is arranged on sidewalls of the channel layer. The first dielectric layer has a first maximum width measured between outermost sidewalls of the first dielectric layer. The first source/drain conductive line has a second maximum width measured between the outermost sidewalls of the first source/drain conductive line. The second width is greater than the first width.

Abstract: The present disclosure provides a method for topography simulation of a physical structure under a topography-changing process. The method includes initializing a voxel mesh as a three-dimensional (3D) representation of a physical structure by a central processing unit (CPU), generating a batch of particles, simulating a flight path of one of the particles with a ray-tracing method by a parallel processing thread in a graphics processing unit (GPU), identifying a surface normal of a voxel unit in the voxel mesh that intersects the flight path by the parallel processing thread in the GPU, passing parameters describing the one of the particles hitting the voxel mesh from the GPU to the CPU, determining a surface reaction between the one of the particles and the voxel unit by the CPU, and updating the voxel mesh based on the determining of the surface reaction.

Abstract: The present invention relates to a method for analyzing a sequence of a target polynucleotide. Full polymerization is achieved by means of multiple times of polymerization of a nucleotide mixture and polymerase, and a marker is detected while the polymerization reaction is performed. Furthermore, the present invention relates to a kit, capable of being used for analyzing or sequencing a polynucleotide.

Abstract: A semiconductor memory structure includes a ferroelectric layer and a channel layer formed over the ferroelectric layer. The structure also includes a source structure and a drain structure formed over the channel layer. The structure further includes a first isolation structure formed between the source structure and the drain structure. The source structure extends over the cap layer and towards the drain structure.

Abstract: A method for determining well wall collapse of a single well for a fractured-vuggy reservoir is provided. The method includes following steps: S1, treating the single well of the fractured-vuggy reservoir as an isolated reservoir; S2, calculating a water influx rate for the fractured-vuggy reservoir; S3, substituting a formula of the water influx rate into a material balance equation; S4, calculating a change of an oil productivity index without considering the well wall collapse; S5, establishing an optimizing model for obtaining the oil productivity index; S6, calculating the formation pressure at any time in production through step S3; S7, calculating the oil productivity index at any time through the formation pressure, and establishing an optimal objective function; and S8, calculating a difference between the oil productivity index at any time and the theoretically calculated oil productivity index at any time, and determining whether the difference meets an accuracy requirement.