Abstract: Provided are a nanopore preparation and detection method and detection apparatus thereof. The method comprises: forming a nanopore by aggregating a plurality of protein monomers, with a signal detection region of the nanopore being formed in a narrow passage portion of the nanopore; and forming a positive charge cluster in the signal detection region of the nanopore, wherein the charge interaction between the positive charge cluster and negatively charged single molecule analytes that pass through the nanopore can lengthen the residence time of the single molecule analytes in the nanopore. Accordingly, the effective detection of analytes at a single-molecular level is realized, such that single molecule analytes that cannot generate an effective detection signal due to an interaction time with a. nanopore being too short can be effectively detected, the prevalence of single molecule analytes can be significantly improved, and different analytes and detection requirements are accommodated.

Abstract: Provided is a method for delaminating a composite by immersing the composite into a delamination solution; wherein the composite comprises a metal substrate and a coating applied on one side or both sides of the metal substrate, wherein the coating comprises a polymeric binder; and wherein the polymeric binder comprises an aqueous copolymer. The use of delamination solution comprising a strong base allows for complete delamination of the composite in a highly efficient and extremely fast manner. Furthermore, the delamination method disclosed herein circumvents complex separation processes, contamination and corrosion of the metal substrate and enables an excellent materials recovery. An application of the method for delaminating an electrode for a battery is disclosed herein.

Abstract: A bracket, a thrombelastography device, and a support system are disclosed. The bracket comprises: a fixed support part (101), a movable support part (102), and a connection part (103). The connection part comprises a first fixing connection member (1031) and a second fixing connection member (1032). The first fixing connection member is fixedly connected to the fixed support part; the second fixing connection member is fixedly connected to the movable support part; the first fixing connection member is connected to the second fixing connection member in point contact fashion, such that the first fixing connection member and the second fixing connection member can rotate relative to each other; the movable support part is fixedly connected to a supported object; when driven by the supported object, the movable support part rotates relative to the fixed support part by means of the point contact between the first fixing connection member and the second fixing connection member.

Abstract: A method, an apparatus, and a computer program product for wireless communication are provided. The apparatus may schedule a mini-slot for transmission of unicast data to a particular user equipment. The mini-slot may be scheduled in a portion of a downlink common burst portion of a slot. The apparatus may transmit a signal, including the unicast data, within the mini-slot.

Abstract: Techniques are disclosed for promulgating service information and topology information in a network in a high availability manner. An example device is configured to create a first service and topology exchange protocol (STEP) document. The first STEP document includes service information and topology information. The example device is configured to send the first STEP document to a first STEP repository for forwarding to at least one subscribing network device. The example device is also configured to send the first STEP document to a second STEP repository for forwarding to the at least one subscribing network device.

Abstract: Provided in the present invention is an enzyme reaction solution for constructing a sequencing library and the use thereof. The enzyme reaction solution comprises an enzyme composition and a reaction buffer, wherein the enzyme composition comprises a nucleic acid endonuclease, a DNA polymerase, and a polynucleotide kinase; and the reaction buffer comprises a metal salt, a substrate, and a buffer medium aqueous solution. The present application aims to optimize the formulation of an enzyme reaction solution. The cleavage, terminal repair and addition of A to the terminal of a nucleic acid sample is achieved by a one-step reaction. In a suitable buffer system, the enzyme digestion reaction rate and the terminal repair reaction rate reach a balance. In the case where the initial amount of the sample is 100 pg to 1 µg and the processing time is the same, a sequencing library with a consistent length distribution is obtained.

Abstract: Presented are systems and methods for signal transmission. A wireless communication device may receive downlink control information (DCI) from the wireless communication node. The DCI may comprise a plurality of blocks, each one or more blocks of the plurality of blocks for a respective wireless communication device. The wireless communication device may receive the DCI to trigger an aperiodic sounding reference signal (SRS). The wireless communication device may receive a configuration from the wireless communication node via higher layer signaling. The wireless communication device may receive the configuration to configure parameter srs-TPC-PDCCH-Group as typeA, typeB, typeC or typeD.

Abstract: A combination comprising a tricycle compound and use thereof in the preparation of a medicament for treating HBV. The combination is a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof and any one drug in the following groups a-c: a. a hepatitis B surface antigen inhibitor, b. a reverse transcriptase inhibitor, and c. a hepatitis B surface antigen inhibitor and a reverse transcriptase inhibitor.

Abstract: A full-path circuit delay measurement device for a field-programmable gate array (FPGA) and a measurement method are provided. The measurement device includes two shadow registers and a phase-shifted clock, where the two shadow registers take an output of a measured combinational logic circuit as a clock and sample the phase-shifted clock SCLK as data; the two shadow registers are respectively triggered on rising and falling edges of the output of the measured combinational logic circuit to sample the phase-shifted clock; outputs of the two shadow registers are delivered by an OR gate as an input into a synchronization register; a clock of the synchronization register serves as a clock MCLK of the measured combinational logic circuit; an output of the synchronization register serves as that of the circuit delay measurement device; the phase-shifted clock SCLK and the clock MCLK of the measured combinational logic circuit have the same frequency.

Abstract: The present disclosure provides an anti-PD-L1/anti-B7-H3 multispecific antibody capable to effectively block the interaction between PD-L1 and its receptor PD-1, and suppress the T-cell inhibitory effect of B7-H3 protein. The multispecific antibody may have high binding affinity to both of a PD-L1 protein and a B7-H3 protein.

Abstract: Certain aspects of the present disclosure provide techniques for determination, selection, configuration, and/or indication of resource allocation patterns for scheduling services, such as reliable low-latency services (e.g., ultra-reliable low latency communications (URLLC)) and other services in a wireless network, such as new radio (NR) (e.g., a 5G network). A method of wireless communication by a user equipment (UE) is provided. The method generally includes determining a resource allocation pattern that defines resources, from a plurality of configured resource allocation patterns, wherein at least one of the plurality of configured resource allocation patterns comprises a plurality of resource elements with at least a first resource element associated with a first resource allocation restriction and at least a second resource element associated with a second resource allocation restriction and communicating based on the determined resource allocation pattern.

Abstract: An audio playback device includes an audio playback apparatus and a charging storage box that satisfies placement of the audio playback apparatus, the audio playback apparatus includes a piece of connecting soft rubber, a sound nozzle fixedly connected to a side end portion of the connecting soft rubber, a speaker fixedly mounted inside the sound nozzle, a circuit component housing fixedly mounted at another side end portion of the connecting soft rubber, and a piece of memory metal cooperatively installed in the connecting soft rubber. The present device adopts ear clip type wearing, one end of the sound nozzle is inserted into the ear, the circuit component housing is placed behind the ear, since the soft rubber has a certain elasticity and with the unique shape of the sound nozzle, the audio playback apparatus can be firmly clamped on the ear.

Abstract: To clean components in semiconductor manufacturing equipment, such as an optical system or an electron beam system, a component is heated in a chamber. A supercritical fluid formulation is applied to the component in the chamber, which removes molecular and/or particulate contaminants. The supercritical fluid formulation can include one or more of carbon dioxide, water, HCF, alkane, alkene, nitrous oxide, methanol, ethanol, or acetone.

Abstract: The present invention provides novel scaffolded HIV-1 vaccine immunogens. Some of the scaffolded immunogens contain a soluble gp140 trimer linked to the N-terminus of the nanoparticle subunit and a T-helper epitope that is fused via a short peptide spacer to the C-terminus of the nanoparticle subunit. Some other immunogens of the invention contain a soluble gp140 trimer protein that is linked to a stable nanoparticle via a short peptide spacer that is a T-helper epitope. Some of the scaffolded immunogens contain a gp140 trimer immunogen presented on a nanoparticle platform formed with I3-01 protein, E2p, or variants of protein 1VLW. Also provided in the invention are nucleic acids that encode the various vaccine immunogens described herein, and expression vectors and host cells harboring the nucleic acids. The invention further provides methods of using the scaffolded HIV-1 vaccine immunogens for preventing or treating HIV infections.

Abstract: Some embodiments provide a method for a first smart NIC of multiple smart NICs of a host computer. Each of the smart NICs is for performing virtual networking operations for a set of data compute machines executing on the host computer. The method determines that the first smart NIC is elected to communicate with a network management and control system that configures the virtual networking operations. The method receives a set of configuration data for the virtual networking operations from the network management and control system. The method provides the received set of configuration data to the other smart NICs of the host computer.

Abstract: A flexible display device is provided. The display device includes an outer frame, a first supporting plate, a second supporting plate, a roller device, rotating shaft assemblies, and a transmission assembly. When the second supporting plate and the first supporting plate are expanded relatively or merged with each other, the transmission assembly guides the roller device and the rotating shaft assemblies to rotate simultaneously, ensuring smooth transmission of screens in a stretching process or a contracting process, and improving service life of a flexible display screen.

Abstract: This application discloses a control circuit of a PTZ camera and control method. The control circuit includes: a motor drive circuit, a monitoring circuit, a gimbal motor, and a microprocessor. The motor drive circuit, the gimbal motor, and the microprocessor are electrically connected to the monitoring circuit respectively. The gimbal motor is configured to drive a rotor of the camera to rotate. The monitoring circuit is configured to acquire a first signal between the motor drive circuit and the gimbal motor, and output a second signal to the microprocessor according to the first signal. The microprocessor is configured to obtain an in-place status of the gimbal motor according to the second signal. The motor drive circuit is configured to control an operating state of the gimbal motor according to the in-place status. As a result, the deviation caused by back-and-forth rotation of the gimbal motor can be eliminated in time.

Abstract: The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.

Abstract: A device is disclosed which includes at least one integrated circuit die, at least a portion of which is positioned in a body of encapsulant material, and at least one conductive via extending through the body of encapsulant material.

Abstract: This disclosure provides methods, devices, and systems for physical uplink shared channel (PUSCH) repetition based on support signaling, such as an uplink grant that includes a time domain resource assignment for transmitting one or more data repetitions that may cross a slot boundary. The UE may identify directions (for example, uplink, downlink, flexible) for one or more symbols spanning a transmission duration of the time domain resource assignment. The directions may be determined using a dynamic slot format indication (SFI), or semi-static SFIs may be used as a fallback (when dynamic slot format indications do not meet a target reliability). The uplink grant may include an indication of which symbol directions can be used for the one or more data repetitions. A subset of the one or more symbols for scheduling the one or more data repetitions may be determined based on the identified directions.