Abstract: A method for optimizing design and manufacture of a self-supporting structure based on multi-axis 3D printing are provided, which comprises the following steps: using a structural topology optimization method based on an SIMP model to achieve the optimal configuration design of a complex structure, converting an image into a binary image, and post-processing the result of topology optimization; determining an overhanging angle of a structure boundary, and determining the printing direction of different printing partitions according to the classification; performing integrated optimization of angle constraints; extracting structural information, establishing a 3D solid model, and then partitioning and slicing the model, and generating a printing path for self-supporting multi-axis 3D printing manufacturing. The present disclosure has the beneficial effects that the self-supporting structure is generated in the optimization process, no additional support is needed in the printing process.

Abstract: An integrated optimal designing and manufacturing method involving structure layout, geometry and 3D printing is provided, the method includes: building a minimum connection base structure, establishing a layout optimization model after screening out components that violate an overhang angle constraint, adding all components to the layout optimization model in batches; considering a manufacturing constraint about an overhang angle of each component, merging the components and fusing nodes in a layout by iterative optimization, and processing crossed components; extracting structure information, building a 3D solid model, and then slicing the solid model and generating a printing path for 3D printing. Considering the overhang angle constraint of the components in the printing manufacturing, the self-supporting structure is generated optimally, and no additional support is needed in the printing process; the structure is normalized by multiple iterations of component fusion and node movement processing.

Abstract: The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

Abstract: The present disclosure provides an extracorporeal focused ultrasound treatment device for a pelvic disease. The treatment device includes an ultrasonic transducer and a treatment couch. Sound emitting surface of the ultrasonic transducer is a spherical surface having a first notch, a second notch and a third notch, the first notch and the second notch are respectively positioned at two intersections of the spherical surface and a diameter perpendicular to the main great circle, and the third notch connects the first notch with the second notch; a cross-section of the sound emitting surface parallel to the main great circle is in a shape of an arc; and an ultrasonic wave generated by the sound generation unit is focused at a center of the sphere corresponding to the sound emitting surface. The treatment couch is configured for a human body to lie in a lithotomy position.

Abstract: Provided are a control system of an electromagnetic relay and an electromagnetic relay. The control system of an electromagnetic relay includes an electromagnet coil, a first resistor, and a first voltage control element. A first terminal of the electromagnet coil is connected to a first terminal of a first power circuit through the first resistor. A second terminal of the electromagnet coil is connected to a second terminal of the first power circuit. The first voltage control element is connected in parallel to the electromagnet coil. The first voltage control element can control the magnitude of the voltage across the electromagnet coil, so that the force to which armature iron is subjected gradually changes.

Abstract: A signal connector includes a backplane connection part and a subcard connection unit. A first signal terminal pair and a first shielding piece are disposed on the backplane connection part. A second signal terminal pair and a second shielding piece are disposed on the subcard connection unit. When the backplane connection part and the subcard connection unit cooperate with each other, the first signal terminal pair is combined with the second signal terminal pair in a one-to-one manner. The first shielding piece and the second shielding piece form a shielding cavity in which the first signal terminal pair and the second signal terminal pair are wrapped.

Abstract: A pyridopyrimidinone derivative as represented by formula I, and a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt thereof or a prodrug thereof. The pyridopyrimidinone derivative has a good SOS1 inhibitory effect.

Abstract: Disclosed is a method for evaluating thicknesses of cobalt-rich crusts on seamounts, which comprises following steps: dividing a study area of cobalt-rich crusts into geological grid units, assigning crust thickness values to geological grid units; obtaining the crust thicknesses of the geological sampling stations in a preset influence range in the adjacent areas based on geological sampling station information; estimating the crust thicknesses in a certain distance range of the stations by a “distance-slope” spatial interpolation method, and through a spatial similarity of a crusts spatial distribution caused by a relationship between the distance and the slope, assigning values to grid units outside adjacent areas and within an influence range of the spatial similarity relationship; assigning values to the geological grid units that failed to obtain crust thickness value through an expected assignment method, and obtaining the crust thicknesses of the study areas.

Abstract: Disclosed are compounds of Formula (I?) methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer.

Abstract: A maintenance base station includes at least one function component, a man-machine interaction component and a controller. The man-machine interaction component is configured to receive a user input and determine a man-machine interaction signal based on the user input. The man-machine interaction signal indicates a device type and a device task type. A device indicated with the device type at least includes a cleaning robot or the function component of the maintenance base station. The controller electrically connecting the function component and the man-machine interaction component, and is configured to receive the man-machine interaction signal and call the corresponding device to work based on the man-machine intction signal.

Abstract: An optical device and the prism module thereof are provided. The prism module includes a first prism, a second prism, and a third prism. The second prism is disposed beside the first prism. The third prism is adhered to the second prism. First light enters the first prism, is reflected plural times in the first prism, enters the second prism, and is emitted from the second prism. Second light enters the second prism, is reflected plural times in the second prism, and is emitted from the second prism. Third light sequentially passes through the third prism and the second prism, enters the first prism, is reflected plural times in the first prism, and is emitted from the first prism.

Abstract: A dual-purpose blowing-suction machine includes a casing, an air suction opening, an air blowing opening, a dust barrel, an air duct, and a motor. The dust barrel is in communication with the air suction opening, and the motor is provided with an air inlet hole in communication with the air duct and an air outlet cavity in communication with the air blowing opening. The dual-purpose blowing-suction machine provides an inner cavity in the casing, and the casing is provided with an air inlet in communication with the inner cavity; and a front through hole is provided between the dust barrel and the air duct, a rear through hole is provided between the air duct and the inner cavity, and a baffle that switches opening and closing of the front through hole and the rear through hole is arranged in the air duct.

Abstract: The disclosure relates to a protein-type nanoparticle for multi-specific antibody delivery, a preparation method, and its application. The protein-type nanoparticle includes a polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interactions. The protein is at least one of albumin, globulin and cell wall protein. The protein-type nanoparticle of the present disclosure has excellent stability and biocompatibility. The protein-type nanoparticle is used to prepare a multi-specific antibody delivery platform (?Fc-NP) by binding anti-IgG-Fc antibody or anti-IgG-Fc antibody fragment, which can stably, quickly and easily bind to multiple specific antibodies through antigen-antibody interaction and enhance the therapeutic effect of specific antibodies.

Abstract: An integrated circuit (IC) structure includes a semiconductor substrate, a first gate line, a second gate line, and a first auxiliary gate portion. The semiconductor substrate comprises a semiconductor fin. The semiconductor fin extends substantially along a first direction. The first gate line and the second gate line extend substantially along a second direction different form the first direction from a top view. The first auxiliary gate portion connects the first gate line to the second gate line from the top view.

Abstract: The present disclosure provides a bimetallic coordination metal-organic framework material, a preparing method thereof, and an application thereof. In the bimetallic coordination metal-organic framework material, carboxyl groups and soft groups of ligands are coordinated with coordination metal ions to assemble a structure having space and functions divided into covalent charge carrier layers and charge storage ion layers. Further, through the conjugation effect, the bimetallic coordination metal-organic framework material has unique electromagnetic properties, good electrical conductivity, and magnetic coupling performance. Thus, the bimetallic coordination metal-organic framework material is used as superconducting materials, conductive materials, semiconductor materials, or electromagnetic materials.

Abstract: A method for fabricating semiconductor devices is disclosed. The method includes forming a gate trench over a semiconductor channel, the gate trench being surrounded by gate spacers. The method includes sequentially depositing a work function metal, a glue metal, and an electrode metal in the gate trench. The method includes etching respective portions of the electrode metal and the glue metal to form a gate electrode above a metal gate structure. The metal gate structure includes a remaining portion of the work function metal and the gate electrode includes a remaining portion of the electrode metal. The gate electrode has an upper surface extending away from a top surface of the metal gate structure.

Abstract: A three-dimensional scanning system includes a scanning apparatus configured to acquire first raw image data of a scanning target. The three-dimensional scanning system further includes a first field programmable gate array (FPGA) module provided in the scanning apparatus and configured to perform computational preprocessing on the first raw image data to obtain valid first feature data. The three-dimensional scanning system further includes a modeling terminal connected to the scanning apparatus and configured to perform modeling processing based on the first feature data to generate a three-dimensional model of the scanning target.

Abstract: Provided is a fusion protein, comprising a protein having a hydrophobic region, a peptide linker, a protein fusion receptor. The peptide linker links the protein having a hydrophobic region to the protein fusion receptor. The protein fusion receptor is an Fc receptor fragment that specifically recognizes an Fc fragment of an antibody, and the protein having a hydrophobic region is a serum albumin. Also provided is a nano-assembly consisting of the fusion protein and a hydrophobic degradable polyester and a derivative thereof. Also provided is an application of the nano-assembly having excellent stability in an antibody delivery platform. The constructed nano-assembly platform is creatively applied in the preparation of immunotherapeutic drugs or therapeutic drugs for tumors or autoimmune diseases or inflammations.