Abstract: The present invention relates to isolated polypeptides having alpha-amylase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains.

Abstract: Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.

Abstract: A circuit includes a period calculator and a pulse width calculator. The period calculator is configured for receiving a first predetermined digital code and a second predetermined digital code, and for calculating a first calculated period value according to the first predetermined digital code, and calculating a second calculated period value according to the second predetermined digital code. The first predetermined digital code has a first predetermined period value, and the second predetermined digital code has a second predetermined period value. The pulse width calculator is configured for receiving a predetermined pulse width, and calculating a first pulse width code corresponding to the predetermined pulse width according to the first predetermined period value, the second predetermined period value, the first calculated period value, the second calculated period value and the predetermined pulse width.

Abstract: A post insulator includes an insulating post including a first end and a second end that are opposite to each other, a high-voltage-end grading ring connected to the first end of the insulating post, the high-voltage-end grading ring being insulated from the insulating post, a grounding-end grading ring connected to the second end of the insulating post, the grounding-end grading ring being insulated from the insulating post, and a charge control ring disposed on an outer surface of the insulating post, the charge control ring being insulated from the insulating post, and the charge control ring being configured to accumulate surface charges.

Abstract: Methods, apparatus and systems for backward compatible multi-access protocol data unit session (PDU) registration and deregistration are described. One method of digital communication includes establishing, by a session management function operating in a communication network, a PDU session for a wireless device and transmitting, upon successfully establishing the PDU session, a registration request to a network-side function to register a context of a PDU session of the wireless device with the network-side function, wherein the registration request identifies a set of session management functions that includes the session management function.

Abstract: A lid controller hub (LCH) comprising processing components located in the lid of a mobile computing device, such as a laptop, processes sensor data generated by input sensors (microphones, cameras, touchscreen) and provides for improved and enhanced experiences over existing devices. For example, the LCH provides hardened privacy and the synchronization of touch display activities with the display refresh rate, the latter providing for a smoother and more responsive touch experience over existing designs. The LCH enables continuous gestures comprising touch gesture and in-air gesture portions as well as multi-plane gestures in which an initial touch gesture places the device into a mode or context in which it recognizes and acts upon subsequent in-air gestures. Touch operations of a mobile computing device can be based on user presence, user engagement, and a level of user interaction with the device.

Abstract: Disclosed are a polyvinyl thioether ester, a preparation method therefor and use thereof. The polyvinyl thioether ester is obtained by subjecting a binary acetylenic acid ester-based internal-alkyne monomer and a dithiol monomer as starting materials to a solution polymerization reaction. The staring materials of the polymerization reaction are easy to obtain, and no by-products are produced during the process of the polymerization reaction. The polymerization reaction has a wide substrate applicability and a good functional group compatibility, such that various functional groups can be conveniently introduced. No catalyst is used in the polymerization reaction, and, the influence of a catalyst residue on the optical and electrical properties and the biological properties of a polymer material can be eliminated.

Abstract: Implementations of the present disclosure provide coloring methods that sort and pre-color nodes of G0-linked networks in a multiple-patterning technology (MPT)-compliant layout design by coordinate. In one embodiment, a method includes identifying target networks in a circuit layout, each target network having two or more linked nodes representing circuit patterns, and each target network being presented in an imaginary X-Y coordinate plane, assigning a first feature to a first node in each target network, the first node is determined using a coordinate-based method, and assigning the first feature and a second feature to remaining nodes in each target network in an alternating manner so that any two immediately adjacent linked nodes in each target network have different features.

Abstract: The disclosure describes a low-orbit satellite deorbit control method and system based on a particle swarm algorithm. The method includes: constructing an objective function according to a position parameter and a perturbation acceleration of each of particles in a particle swarm as well as a preset Lagrangian multiplier and a penalty factor; determining an objective fitness of each particle and a population fitness of the particle swarm based on the objective function, updating the position parameter and the velocity of each particle, and obtaining a population optimal fitness at a maximum number of iterations; updating the Lagrangian multiplier and the penalty factor according to the population optimal fitness, comparing the objective deviation value with a preset convergence condition, and determining an objective population fitness and an objective position parameter according to a comparison result to obtain an objective deorbit mode.

Abstract: A polyethylene composition having from about 0.5 to about 20 wt % of alpha-olefin derived units other than ethylene-derived units, with the balance including ethylene-derived units, total internal unsaturations (Vy1+Vy2+T1) of from about 0.15 to about 0.40 per 1000 carbon atoms, an MI of from about 0.1 to about 6 g/10 min, an HLM1 of from about 5.0 to about 40 g/10 min, a density of from about 0.890 to about 0.940 g/ml, a Tw1-Tw2 value of from about ?50 to about ?23° C., an Mw1/Mw2 value of from about 2.0 to about 3.5, an Mw/Mn of from about 4.5 to about 12, an Mz/Mw of from about 2.5 to about 3.0, an Mz/Mn of from about 15 to about 25, and a g?(vis) greater than 0.90.

Abstract: The present invention discloses a crystalline aluminum phosphite, a preparation method thereof and an application thereof as or for the preparation of a flame retardant or a flame retardant synergist. The preparation method has the following processes: 1, reacting aluminum hydrogen phosphite with an aluminum-containing compound in water at 80-110° C. to obtain a precipitate in the presence of no strong acid or a small amount of strong acid; 2, washing and filtering the precipitate; 3, drying the precipitate at 100-130° C.; 4, continuously heating the dried solid step by step at a low speed, where the material temperature is increased to not exceeding 350° C. from room temperature at about 5-10 h, with a temperature rise rate not exceeding 5° C./min.

Abstract: A holding brake monitoring circuit system, an elevator system, and a holding brake monitoring method. The holding brake monitoring circuit system includes a plurality of opening sensors corresponding to holding brakes, wherein the number of the opening sensors is an even number greater than 3, and the opening sensors are configured to be paired to form at least two working groups, and each of the working groups is configured to output an output signal for judging status of the holding brake(s).

Abstract: Devices, systems and methods for unified rounding in sub-block based prediction are described. In a representative aspect, a method of video processing includes generating, for a processing of a current block of video, a pairwise merge candidate based on a pair of motion candidates, and performing, based on the pairwise merge candidate, a conversion between the current block and a bitstream representation of the video. In another representative aspect, a method of video processing includes generating, for a current block of video coded using a geometry partition mode, a uni-prediction motion candidate based on a scaled motion vector and a List0 motion vector, and performing, based on the uni-prediction motion candidate, a conversion between the current block and a bitstream representation of the video.

Abstract: The present disclosure provides an anti-lost device, comprising a first casing, an electronic component, a second casing, and a metal ring. The first casing comprises a first accommodating part. The electronic component is disposed at the first accommodating part. The second casing comprises a second accommodating part corresponding to the first accommodating part. The first casing is connected to the second casing. The metal ring is interconnected between the first casing and the second casing and is disposed at an outside of the first accommodating part and the second accommodating part. The metal ring comprises an extension part extending to an outside of the first casing and the second casing. The extension part comprises a through hole. The metal ring can improve the load-bearing and tensile strength of the anti-lost device.

Abstract: The present disclosure belongs to the technical field of gene therapy, and specifically relates to a series of lipid compounds as well as lipid vectors, nucleic acid lipid nanoparticle compositions, and pharmaceutical preparations containing the same. The compound having the structure of formula (I) provided by the present disclosure may be used in combination with other lipid compounds to prepare a lipid vector, which exhibits pH responsiveness, has high encapsulation efficiency for nucleic acid drugs, and greatly enhances the in-vivo delivery efficiency of nucleic acid drugs. Moreover, it is possible to select lipid compounds with different structures as lipid vectors to adjust the enrichment of nucleic acid drugs in different organs, thereby having good market application prospect.

Abstract: Calibration of eye tracking is improved by collecting additional calibration pairs when user is using apps with eye tracking. A user input component is presented on a display of an electronic device, detecting a dwelling action for user input component, and in response to detecting the dwelling action, obtaining a calibration pair comprising an uncalibrated gaze point and a screen location of the user input component, wherein the uncalibrated gaze point is determined based on an eye pose during the dwelling action. A screen gaze estimation is determine based on the uncalibrated gaze point, and in response to determining that the calibration pair is a valid calibration pair, training a calibration model using the calibration pair.

Abstract: A hybrid integrated optoelectronic chip including an optoelectronic chip and a silicon photonic chip, a material of the optoelectronic chip being different from a material of the silicon photonic chip. The optoelectronic chip includes at least one first waveguide. The silicon photonic chip includes at least one second waveguide and an installation recess. The optoelectronic chip is installed in the installation recess, and the first waveguide is optically connected to the second waveguide.

Abstract: A blower includes an air tube, an electric motor, a fan, a housing, and a circuit board. The air tube is provided with an air duct extending along a first straight line. The electric motor is arranged in the air duct. The fan is operative to be driven by the electric motor. The housing is provided with a handle configured to be held by a user and a joining portion configured for connecting to a power source. And the circuit board is electrically connected to the electric motor. The air tube is provided with an air inlet at one end of the air duct and an air outlet at another end of the air duct. The fan is arranged in the air duct, and when the fan rotates, a blowing airflow entering the air duct from the air inlet is generated.