Abstract: A series of PRMT5 inhibitor compounds are described. The compounds are useful as PRMT5 inhibitor compounds and in the treatment of PRMT5 mediated diseases, disorders, and symptoms thereof.

Abstract: A computer-implemented method of controlling power consumption in a multi-processor computing device comprises determining a first value for a first power setting associated with a first processor based on a sound level generated by the multi-processor computing device; determining a second value for the first power setting based on a power consumption level of the multi-processor computing device; comparing the first value to the second value; and causing the first processor to perform one or more operations based on the lesser of the first value and the second value.

Abstract: Disclosed are the use of a benzoate compound as shown in formula I, a geometric isomer thereof, a pharmaceutically acceptable salt thereof and/or a solvate thereof or a hydrate thereof, and a pharmaceutical composition containing the above-mentioned compound in the prevention and treatment of SARS-CoV-2 infections.

Abstract: The present disclosure relates to a BLUETOOTH scanning control method, a mobile terminal, and a storage medium. The method comprises: after receiving a BLUETOOTH scanning instruction, setting filter attribute information, wherein the filter attribute information is device attribute information of a BLUETOOTH device, which information is to be obtained by means of filtering in the present BLUETOOTH scanning operation; and acquiring the filter attribute information, performing BLUETOOTH scanning according to the filter attribute information, and displaying BLUETOOTH device information obtained by means of scanning. In the present embodiment, during BLUETOOTH scanning, a BLUETOOTH scanning operation is performed according to BLUETOOTH device information corresponding to the set filter attribute information, so as to obtain a BLUETOOTH device obtained by means of filtering and display the BLUETOOTH devices obtained by means of filtering, thereby reducing a scanning period, and achieving the aim of fast scanning.

Abstract: A method of updating a trained cardinality estimation model includes receiving a cardinality estimation model with cardinality labels and detecting a drift in underlying data or predicates of the cardinality estimation model. The type of the detected drift is determined and new test queries that mimic test queries for the detected drift are synthesized. A portion of the synthesized test queries is selected to reduce annotation cost and used to update the cardinality estimation model.

Abstract: A leather defect detection system comprises a worktable, a conveying mechanism, an image capture module, a model training computing device and an embedded computing device, the worktable is used to place a to-be-detected leather; the conveying mechanism is movably disposed on the worktable; the image capture module is disposed on the conveying mechanism, when the conveying mechanism is actuated, relative positions of the image capture module and the to-be-detected leather change synchronously to capture a plurality of to-be-detected images respectively; the model training computing device uses a plurality of historical leather images captured by the image capture module to perform calculation to establish a defect identification model, and the defect identification model is transcoded into the embedded computing device, so that the embedded computing device is capable of directly using the transcoded defect identification model to perform defect identification on the to-be-detected images.

Abstract: The invention relates to antibody therapies in veterinary medicine, in particular full-length antibodies and antibody fragments, by providing methods to improve the production of heterodimeric antibodies for veterinary medicine as well as providing related products and uses.

Abstract: A semiconductor device includes a first nitride-based semiconductor layer, a second nitride-based semiconductor layer, a group of negatively-charged ions, and a field plate. The gate electrode and the drain electrode disposed above the second nitride-based semiconductor layer to define a drift region therebetween. The group of negatively-charged ions are implanted into the drift region and spaced apart from an area directly beneath the gate and drain electrodes to form at least one high resistivity zone in the second nitride-based semiconductor layer. The field plate is disposed over the gate electrode and extends in a region between the gate electrode and the high resistivity zone.

Abstract: Provided are compounds represented by general formula (I), which can be used for treating ATR kinase-mediated diseases, such as proliferative diseases, such as cancer. Further provided are a pharmaceutical composition of the compound represented by general formula (I), a use thereof in treating ATR kinase-mediated diseases, and a preparation thereof.

Abstract: A supramolecular nano-drug based on irinotecan and niraparib, and a preparation method and application thereof are provided. The nano-drug is a stable supramolecular nanostructure with a regular geometric appearance, which is formed by self-assembling irinotecan and niraparib through supramolecular acting forces, such as hydrogen bonds, and hydrophobic Van Der Waals force by a dynamic supramolecular self-assembly method. The supramolecular nano-drug formed in the present disclosure is capable of significantly improving the sensitivity of colorectal cells to the irinotecan, and the quantity of DNA damages induced in the colorectal cells is significantly higher than that induced by the irinotecan as a single chemotherapeutic drug. The supramolecular nano-drug of the present disclosure can not only induce death of colorectal cancer cells in vitro, but also play a role in treating the colorectal cancer in vivo after being administrated intravenously.

Abstract: Compounds which are oxadiazaborole derivatives are disclosed, including compounds of the following genus: The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

Abstract: Solid forms comprising 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.

Abstract: A prediction model training method includes transmitting a model to be trained by a plurality of training devices, the model to be trained including feature extraction layers and prediction layers, classifying the plurality of training devices into at least one group based on extracted user features, receiving, from the plurality of training devices, model parameters including first parameters corresponding to the feature extraction layers and second parameters corresponding to the prediction layers, performing global federated aggregation based on the first parameters, performing intra-group federated aggregation for each of the at least one group, based on the second parameters of one or more of the plurality of training devices in a respective group, and transmitting, to the plurality of training devices, the global federated aggregation result and the intra-group federated aggregation result.

Abstract: The invention disclose a pixel in an image sensor capable of detecting infrared light and associated fabrication method. The image sensor includes a semiconductor substrate has a first photodiode and a second photodiode adjacent to the first photodiode. A planarized dielectric layer having a recessed region is disposed on a first side of the semiconductor substrate. A first color filter disposed on the planarized dielectric layer aligned with the first photodiode and configured to transmit light of a first wavelength range. A second color filter disposed in the recessed region and on the planarized dielectric layer. The second color filter is aligned with the second photodiode, and configured to transmit light of a second wavelength range that is different from the first wavelength range. A first depth-wise thickness of the first color filter is less than a second depth-wise thickness of the second color filter.

Abstract: A non-curable thermally conductive material contains: (a) a matrix material containing: (i) 90 to 98 wt % of a non-functional non-crosslinked organosiloxane fluid having a dynamic viscosity of 50 to 350 centiStokes; and (ii) 2 to less than 10 wt % of a crosslinked hydrosilylation reaction product of an alkenyl terminated polydiorganosiloxane having a degree of polymerization greater than 300 and an organohydrogensiloxane crosslinker with 2 or more SiH groups per molecule where the molar ratio of SiH groups to alkenyl groups is 0.5 to 2.0; (b) greater than 80 wt % to less than 95 wt % thermally conductive filler dispersed throughout the matrix material; and (c) treating agents selected from alkyltrialkoxy silanes where the alkyl contains one to 14 carbon atoms and monotrialkoxy terminated diorganopolysiloxanes having a degree of polymerization of 20 to 110 and the alkoxy groups each contain one to 12 carbon atoms dispersed in the matrix material.

Abstract: The present disclosure provides methods and systems for fusing chroma intra prediction modes. An exemplary method includes: generating a plurality of predicted chroma samples associated with a pixel, by using a plurality of chroma intra prediction modes respectively; and determining a first predicted chroma sample, based on a weighted sum of the plurality of predicted chroma samples.

Abstract: The present disclosure provides a signal processing method and apparatus, a device, and a storage medium. The method includes: acquiring a signal set to be processed that carries base station information and base station access time; determining a first signal subset that further carries position information in the signal set to be processed; determining position information of a base station of a first type deployed in a subway station according to the base station information and the position information that are carried by the signal of the first signal subset; and determining position information of a base station of a second type deployed in a subway tunnel according to the position information of the base station of the first type, and the base station information and base station access time that are carried by the signal of the signal set to be processed.

Abstract: A device and a method for producing hydrogen and byproduct oxygen by using green electricity electrolyzed water are provided. The device comprises an oxygen purifying system, a heat exchange system, an air separation compression and expansion system, an air separation rectification system and a liquid oxygen storage system. The method comprises the following steps: first, purifying oxygen prepared by electrolyzing water by green electricity to remove impurities such as hydrogen, carbon monoxide, carbon dioxide and water in the oxygen, then feeding the pure oxygen into the heat exchange system, performing heat exchange liquefaction to obtain liquid oxygen, coupling the liquid oxygen generated by rectification of the air separation rectification system, and obtaining pressurized oxygen through the heat exchange system and the air separation compression and expansion system.

Abstract: The amphibious unmanned patrol vehicle includes a buoy, a waterproof cable and a submersible amphibious vehicle. An end of the waterproof cable is connected to a first controller of the buoy; and another end thereof is connected to a second controller of the submersible amphibious vehicle. A bottom end of the buoy is connected to a top end of the submersible amphibious vehicle which is configured to realize movement and operation of a whole system. The waterproof cable is configured to connect the submersible amphibious vehicle, and the buoy configured to ensure real-time communication between the submersible amphibious vehicle and an external environment during operation of the submersible amphibious vehicle. A height difference between an upper surface and a lower surface of the automatic reeling and unreeling cable device is equal to a thickness of the waterproof cable. The length of the waterproof cable is adjusted automatically in real time.

Abstract: Methods, systems, and devices for wireless communications are described. A user equipment (UE) may monitor one or more first conditions pertaining to non-cellular communications between the UE and a non-cellular network while the UE is operating in a dual networking mode for steering, switching, or splitting traffic (e.g., an access traffic steering, switching, and splitting (ATSSS) mode) between the non-cellular network and a cellular network. The UE may predict an availability status of at least the non-cellular network based on at least one of the one or more first conditions. In some cases, the UE may determine whether to change dual networking modes based on the availability status and may communicate in accordance with the same or a different dual networking mode using at least one of the cellular network, the non-cellular network, or a combination thereof based on the prediction.