Abstract: The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure of formula I: Pharmaceutical compositions containing these compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Inflammation associated with conditions such as IBD and IBS, ocular and otic inflammation, other disorders and conditions such as pruritis, edema, hyponatremia, hypokalemia, ileus, tussis and glaucoma are treatable or preventable with the pharmaceutical compositions of the invention.

Abstract: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits, and systems related to the methods are also described.

Abstract: A method for preparing a coupled polymer, the method comprising the steps of: (i) polymerizing monomers to form a reactive polymer, and (ii) reacting the reactive polymer with a boronic ester containing a cyano group.

Abstract: A stylized QR code generating apparatus is provided, which includes: an image adjusting module having an image detecting unit and a shape distorting unit; and a code stylizing module having a boundary matching unit and a boundary adjusting unit. The image detecting unit detects an error value generated in a QR code when a predetermined image is embedded in the QR code, and the shape distorting unit distorts a plurality of meshes converted from the image to adjust a shape of the image and thereby correct the error value in the QR code. The boundary matching unit matches a plurality of first boundary sections of the QR code with second boundary sections of a predetermined pattern, and the boundary adjusting unit adjusts the first boundary sections to the matched second boundary sections, respectively.

Abstract: A color imaging element, a photosensor and a photoelectric transducer which use a protein and are capable of being stably used for a long time, and methods of manufacturing them are provided. A zinc-substituted cytochrome c552 is immobilized on a gold electrode with a self-assembled monolayer in between to form a blue-light photoelectric transducer. Alternatively, a cytochrome c552 is immobilized on a gold electrode with a self-assembled monolayer in between, and a fluorescent protein absorbing blue light is bonded to the cytochrome c552, thereby forming a blue-light photoelectric transducer. These photoelectric transducers each are used as a color imaging element or a blue-light photoelectric transducer of a photosensor.

Abstract: The present invention relates to a stress-enhanced transistor and a method for forming the same. The method for forming the transistor according to the present invention comprises the steps of forming a mask layer on a semiconductor substrate on which a gate has been formed, so that the mask layer covers the gate and the semiconductor substrate; patterning the mask layer so as to expose at least a portion of each of a source region and a drain region; amorphorizing the exposed portions of the source region and the drain region; removing the mask layer; and annealing the semiconductor substrate so that a dislocation is formed in the exposed portion of each of the source region and the drain region.

Abstract: The present invention relates to a method for producing 3-hydroxypropionic acid by culturing in a glycerol-containing medium a mutant microorganism obtained by inserting or amplifying a gene encoding propanediol utilization protein in a microorganism having the abilities to produce coenzyme B12 and produce 3-hydroxypropionic acid using glycerol as a carbon source. According to the present invention, 3-hydroxypropionic acid can be produced in high yield from glycerol without having to add expensive coenzyme B12 as a cofactor.

Abstract: A system is provided for configuring a Session Initiation Protocol (SIP) device. The system includes at least one SIP server in communication with the SIP device over an Internet Protocol (IP) network. The at least one SIP server includes a database that stores SIP device configuration data and a receiver that receives a first SIP message to initiate SIP device configuration. The at least one SIP server also includes a transmitter that transmits configuration data to the SIP device in response to receiving the first SIP message. The receiver also receives a second message from the SIP device indicating whether the SIP device was successfully configured based on the configuration data.

Abstract: The present application discloses a MOSFET and a method for manufacturing the same. The MOSFET is formed on an SOI wafer, comprising: a shallow trench isolation for defining an active region in the semiconductor layer; a gate stack on the semiconductor layer; a source region and a drain region in the semiconductor layer on both sides of the gate stack; a channel region in the semiconductor layer and sandwiched by the source region and the drain region; a back gate in the semiconductor substrate; a first dummy gate stack overlapping with a boundary between the semiconductor layer and the shallow trench isolation; and a second dummy gate stack on the shallow trench isolation, wherein the MOSFET further comprises a plurality of conductive vias which are disposed between the gate stack and the first dummy gate stack and electrically connected to the source region and the drain region respectively, and between the first dummy gate stack and the second dummy gate stack and electrically connected to the back gate.

Abstract: Compositions relating to a combination of two types of separation matrix; and to variant host cells which contain at least one essential host protein that is fused to an affinity binding tag or has been mutated to replace at least two of a plurality of histidines or basic amino acids are provided. Methods are also provided that relate to isolating a recombinant protein from a lysate.

Abstract: A device and a method for generating input control signals of a serialized compressed scan circuit are provided. A control signal generating device receives a test clock signal from a clock input port and a state enable signal from a state enable bus, and correspondingly generates a shift enable signal, a capture enable signal and a strobe signal. A clock gating device is coupled to the control signal generating device, and receives the shift enable signal, the capture enable signal and the strobe signal. When the shift enable signal is enabled, the clock gating device controls the test clock signal as a serialized scan clock signal. When the strobe signal or the capture enable signal is enabled, the clock gating device controls the test clock signal as a scan clock signal.

Abstract: An electric vehicle and a power system and a motor controller for an electric vehicle are provided. The power system includes a power battery; a charging-discharging socket; a bidirectional DC/DC module connected with the power battery; a driving control switch connected with the power battery and the bidirectional DC/DC module; a bidirectional DC/AC module connected with the driving control switch and the power battery; a motor control switch connected with the bidirectional DC/AC module and a motor; a charging-discharging control module connected with the bidirectional DC/AC module and the charging-discharging socket; and a controller module connected with and configured to control the driving control switch, the motor control switch and the charging-discharging control module according to a current operation mode of the power system.

Abstract: The present invention discloses a charging control circuit, comprising an external power source, a switching circuit, and a charging path circuit comprising a first output circuit and a second output circuit, wherein the external power source is configured to charge a secondary battery through the first output circuit and charge a load through the second output circuit, and the switching circuit is configured to decouple the secondary battery from the load when the external power source is available. Meanwhile, the present invention discloses a charging control method and an electronic device; according to the present invention, because the two output circuits are coupled to the secondary battery and the load, respectively, the load will not divide up the charging current, thereby effectively shortening the charging time and prolonging the service life of the secondary battery.

Abstract: A method and apparatus are described including collecting network information, determining an association, bandwidth allocation and routing scheme based on the collected network information, notifying a mesh access point of the association, the bandwidth allocation and the routing scheme and notifying a client node of its association information. Also described are a method and apparatus including measuring link quality and channel conditions, reporting results of the measuring act to a controller, receiving a routing decision and data forwarding instructions from the controller and forwarding the routing decision and the data forwarding instructions to a client node. Further described are a method and apparatus including measuring link quality and channel conditions, reporting results of the measuring act to a controller, receiving association instructions from the centralized controller and updating previously stored association instructions with the received association instructions.

Abstract: Recombinant microbial cells and methods for producing 5-hydroxytryptophan (5HTP) using such cells are described. More specifically, the recombinant microbial cell comprises an exogenous gene encoding an L-tryptophan hydroxylase, and means for providing tetrahydrobiopterin (THB). Related sequences and vectors for use in preparing such recombinant microbial cells are also described.

Abstract: A device and method include a broadband light source in communication with a waveguide to provide a light signal for interrogating each of a plurality for sensors within the waveguide. An analyzer modulates the light signal with a microwave signal and demodulates and evaluates light signals reflected by the sensors. An amplitude and a phase of each reflected signal from each sensor is distinguished in the time domain and the modulated signal is reconstructed in the frequency domain.

Abstract: Therapeutic compositions containing natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing natriuretic peptides are further described.

Abstract: A process of producing chlorine gas by catalytic oxidation of hydrogen chloride including: incorporating an oxidizing agent such as ozone, hydrogen peroxide solution etc.

Abstract: Multi-stage parallel super-high-speed ADC and DAC of a logarithmic companding law has a voltage follower switch having zero voltage drop, and also has a lossless threshold switch group, wherein a quantization voltage of A/D conversion or D/A conversion is directly obtained through voltage-dividing resistance thereof. The ADC and DAC simplify a conversion process and reduce a conversion error. The ADC and DAC provide multi-stage multi-bit parallel super-high-speed A/D conversion and D/A conversion with logarithmic companding law of a high conversion rate and the low conversion error.

Abstract: In one aspect, a method for de-noising vibratory data of a test component is disclosed. The method may generally include obtaining data related to a plurality of modeled mode shapes of a finite element model of a test component, obtaining data related to a plurality of experimental mode shapes of the test component from a plurality of non-contact vibration measurement devices and de-noising with a computing device the plurality of experimental mode shapes using the plurality of modeled mode shapes to create a plurality of de-noised mode shapes for the test component.