Abstract: The present disclosure discloses a microneedle formulation, a microneedle patch, and preparation methods thereof. The microneedle formulation includes the following components in mass percentage: 15-55% of microneedle scaffold material, 0.05-5% surfactant with cyclic structure, 0-15% of active components, and the remaining being deionized water. The microneedle patch is prepared from the aforementioned microneedle formulation.

Abstract: The present disclosure relates to the field of computer technologies, and discloses an audio processing method and apparatus, an electronic device, and a storage medium. The method includes: obtaining media data to be processed and audio metadata of the media data to be processed; performing first loudness compensation on the media data to be processed based on the audio metadata to obtain first media data, where the first loudness compensation includes loudness compensation for dynamic range control; determining a second loudness compensation value corresponding to peak limiting based on an audio feature of the first media data; and performing second loudness compensation and peak limiting on the first media data based on the second loudness compensation value to determine target media data for playback.

Abstract: The present disclosure relates to the technical field of biotechnology, in particular to carbonyl reductase mutant and its application. Specifically, the present disclosure provides a carbonyl reductase mutant for catalyzing the preparation of (R)-8-chloro-6-hydroxyoctanoic acid ethyl ester from 8-chloro-6-oxooctanoic acid ethyl ester. The mutant protein is a non natural protein and undergoes mutations in three core amino acids related to enzyme catalytic activity in the initial carbonyl reductase. The advantageous effect of the present disclosure is that the carbonyl reductase mutant provided by the present disclosure has the characteristic of efficiently catalyzing the preparation of the precursor substance (R)-8-chloro-6-hydroxyoctanoic acid from 8-chloro-6-oxooctanoic acid ethyl ester, and can efficiently catalyze the oxidation-reduction reaction of 8-chloro-6-oxooctanoic acid, with a product space-time yield of 99.9 g·L?1·h?1 or more.

Abstract: A processing cartridge includes a photosensitive unit including a photosensitive component; a developing unit including a developing component, where the developing unit can move between a contact position where the developing component contacts the photosensitive component and a separated position where the developing component is separated from the photosensitive component relative to the photosensitive unit; a drum coupling for receiving a rotational driving force and transmitting the rotational driving force to the photosensitive component; a developing coupling for receiving the rotational driving force and transmitting the rotational driving force to the developing component; a force-applying component, where the force-applying component can move between an extended position where the developing component is separated from the photosensitive component and a retracted position where the developing component is in contact with the photosensitive component; and an elastic member for moving the force-applyi

Abstract: Provided herein are methods using an anisotropic structure within or in proximity to a biological sample. Such methods can include identifying a location of an analyte in a biological sample or reducing mislocalization of an analyte in a biological sample.

Abstract: A method of forming a molecular separation device is provided. The method comprises growing or depositing a silica MFI zeolite coating on a ceramic support. The method further comprises growing a ZIF-8 coating on the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite comprises applying a first reactant fluid including a metal salt and a second reactant fluid including an imidazole reactant to the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite further comprises reacting the first and second reactant fluid with the silica MFI zeolite coating to produce the ZIF-8 coating. In certain implementations, at least a portion of the ZIF-8 coating is interspersed with a portion of the silica MFI coating. A molecular separation device including the ZIF-8 coating and the silica MFI zeolite is also disclosed.

Abstract: A method for transmitting data, including obtaining, by a transmitting end, coding parameter information of first data, where the coding parameter information indicates information related to physical layer data processing of the transmitting end, the physical layer data processing includes performing first coding on a transport block (TB), and the first coding is a coding mode in which compression and channel coding are separated, or the physical layer data processing includes separately performing second coding on a plurality of sub-TBs obtained based on the TB, and the second coding is a coding mode in which compression and channel coding are combined, and determining, by the transmitting end, whether to transmit the coding parameter information to a receiving end.

Abstract: Disclosed herein are a Cas12i polypeptide and use thereof in a CRISPR-Cas system. Specifically disclosed herein are a Cas12i polypeptide, a Cas12i fusion polypeptide, a guide RNA, a complex formed by the Cas12i polypeptide or fusion polypeptide with the guide RNA, a nucleic acid, a vector, a vector system, a delivery system, a kit, a composition, and a method for modifying a nucleic acid using the components described above.

Abstract: According to some embodiments of the disclosure, a user equipment (UE) may: determine a first physical uplink control channel (PUCCH) resource for a first PUCCH transmission in a first time unit, wherein the first PUCCH transmission carries hybrid automatic repeat request acknowledgement (HARQ-ACK) information bits for at least one semi-persistent scheduling (SPS) physical downlink shared channel (PDSCH) reception, and the first PUCCH resource is on a first frequency domain part; and in the event that the first PUCCH resource overlaps a symbol not intended for an uplink transmission on a second frequency domain part, defer the first PUCCH transmission.

Abstract: An anti-twist structure of a voice coil motor includes a base, a lens housing, a first elastic sheet, a second elastic sheet, a magnet, and a yoke member. The lens housing has first margin wall and a second margin wall, and a first protrusion extends from the first margin wall. The height of the second protrusion is lower than the height of the first protrusion. The yoke member has a first wall, a connection wall, and a second wall. The first wall is disposed above the first protrusion, and the second wall is disposed above the second protrusion. The lens housing has a deflectable angle relative to a horizontal reference line. When the lens housing deflects to a maximum value of the deflectable angle, the first margin wall abuts against the second wall and/or the first protrusion abuts against the first wall.

Abstract: An electronic device including: at least one power management integrated circuit (PMIC) configured to convert energy generated by at least one component of the electronic device into electrical energy; a memory storing at least one instruction; and at least one processor electrically connected to the memory and configured to execute the at least one instruction, where the at least one processor is configured to: determine an operation state of the at least one component; determine whether to drive at least one corresponding PMIC, based on the operation state; and drive the at least one corresponding PMIC based on the determination of whether to drive the at least one PMIC.

Abstract: A display screen and an electronic device are provided. The display screen includes a frame, a cover plate, and a display module. The cover plate and the display module are stacked on the frame. The display module includes a light-emitting unit. A surface of the cover plate is provided with an anti-glare layer formed by etching for scattering light emitted by the light-emitting unit and/or the display module includes a light-homogenizing structure for scattering the light emitted by the light-emitting unit.

Abstract: The present disclosure provides a method and system for monitoring a coal shearer status based on digital twinning, and an electronic device, and relates to the technical field of real-time status monitoring. The method includes: obtaining physical parameters, real-time driving data, and real-time status data of a coal shearer physical entity, where the physical parameters include geometric parameters, material properties, and positional parameters; the real-time driving data includes a real-time position, a real-time speed, and a real-time angle of a rocker arm; and the real-time status data includes real-time vibration information; building a coal shearer digital twin model on a Unity3D engine according to the physical parameters of the coal shearer physical entity; and updating a status of the coal shearer digital twin model based on the real-time driving data and the real-time status data. The present disclosure achieves visual monitoring of a coal shearer status.

Abstract: The disclosure provides a method and device for correction of the multi-channel capacitive sensor. The method includes: under calibrating mode, inputting the calibration signal from the calibration capacitance network module to the multi-channel capacitive sensor, and measuring the output complex voltage at each calibration frequency point; selecting any channel as a reference channel, combining each-channel three-admittance parameters with the output complex voltages at each calibration frequency point, calculating each-channel amplitude-phase correction coefficient relative to the reference channel; under operating mode, inputting a carrier signal to the multi-channel capacitive sensor through the multiple DoF sensitive probe, and measuring the output complex voltages under actual operation; and multiplying the output complex voltages by the correction coefficients, thereby obtaining the multiple sensing channel output signals.

Abstract: A network bandwidth estimation method and apparatus, an electronic device and a storage medium are provided. The method includes: sending a bandwidth test file to a service terminal, and respectively acquiring network state parameters before and after sending the bandwidth test file, wherein a volume of the bandwidth test file is less than a preset file volume threshold; determining a first network bandwidth and a second network bandwidth based on the network state parameters and the volume of the bandwidth test file; inputting the network state parameters, the first network bandwidth, and the second network bandwidth into a current latest network bandwidth estimation model to obtain a target network bandwidth estimation result.

Abstract: Methods, systems, and devices for controlling a medical instrument are discussed herein. For example, image data can be received from a first instrument that is configured to access an anatomical site via a first access path. The image data can be representative of the anatomical site and a second instrument that is configured to access the anatomical site via a second access path. A visual representation of the image data can be displayed in a user interface and a first directional input signal can be received from an input device. An orientation of the first instrument relative to the second instrument can be determined. Movement of the second instrument can be controlled based at least in part on the first directional input signal and the orientation of the first instrument relative to the second instrument.

Abstract: A tethering user equipment (UE) device, such as a cell phone, may be tethered to a tethered device, such as augmented reality (AR) glasses. The tethered device may execute a Web Real-time Communication Protocol (WebRTC) endpoint application, and the tethering UE device may execute a WebRTC endpoint support function. The tethering UE device may access WebRTC signaling functions of a WebRTC operator network on behalf of the tethered device to send and receive AR media data of a WebRTC communication session. The tethered device may present received AR media data (e.g., audio, video, and image data) and may collect and send user movement data (e.g., view orientation, physical movement data, controller interaction data, or the like) to the tethering UE device to cause the tethering UE device to send the user movement data to other devices participating in the WebRTC communication session.

Abstract: Presented herein are system and methods for handling processing of data in cloud environments. A server receives a first dataset generated in response to a function of a first application. A server generates a set of identifiers defining a sequence of processing of the first dataset associated with the function. The identifiers include a first identifier indicating the first application as a predecessor for the first dataset and a second identifier indicating a second application as a successor for the first dataset. The server identifies the second application corresponding to the second identifier as the successor for processing the first dataset. The server communicates at least a portion of the first dataset with a second server hosting the second application to receive a second dataset generated by the second application. The server stores the second dataset in the cloud environment.

Abstract: An apparatus includes a transceiver configured to receive, over a wireless communication channel, at least one controlled-noise signal. The apparatus also includes a processor, operatively coupled to the transceiver. The processor is configured to train, based on the at least one controlled-noise signal, a noise prediction model for the wireless communication channel, and generate, based on the trained noise prediction model, a noise prediction for the wireless communication channel. The processor is also configured to determine, based on the received at least one controlled-noise signal and the noise prediction, a score function for the wireless communication channel.

Abstract: An example user equipment (UE) device for exchanging media data via a network includes a memory configured to store media data; and a processing system comprising one or more processors implemented in circuitry, the processing system being configured to: receive data from a second network device via a radio access network (RAN), the data from the second network device including a local Internet protocol (IP) address type for the second network device and a maximum transmission unit (MTU) size for the second network device; establish a media communication session with the second network device; send data representing the local IP address type and the MTU size for the second network device to a gateway device associated with the RAN; and receive packets of a protocol data unit (PDU) set of the media communication session originating from the second network device via the RAN.