Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

Abstract: The present application is directed to the use of a VEGF-C inhibitor, a VEGFR-2 inhibitor and/or a VEGFR-3 inhibitor as a prophylactic or therapeutic for the treatment of eye disorders such as a maculopathy and pathogenic ocular neovascularization. The application is also directed to the use of a VEGF-C measurement from a biological sample from a mammalian subject as a predictive marker, a selected marker, a responsive marker or a tracking marker for a disease or condition selected from the group consisting of a maculopathy and pathogenic ocular neovascularization.

Abstract: Provided is an intermetallic dielectric layer structure of a silicon-on-insulator device, comprising a silicon-rich oxide layer (54) covering a metal interconnect, a fluorine-silicon glass layer on the silicon-rich oxide layer, and a non-doped silicate glass layer on the fluorine-silicon glass layer; the thickness of the silicon-rich oxide layer (54) is 700 angstroms ±10%; the silicon-rich oxide layer having a greater thickness captures movable ions on an unsaturated bond, such that it is difficult for the movable ions to pass through the silicon-rich oxide layer, thus blocking the movable ions. The present invention has good performance in an integrity evaluation of the gate oxide layer, and avoids damage to the device caused by the aggregation of movable ions at an interface. Also provided are a silicon-on-insulator device and a method of manufacturing the intermetallic dielectric layer of the silicon-on-insulator device.

Abstract: Energy-filtered cold electron devices use electron energy filtering through discrete energy levels of quantum wells or quantum dots that are formed through band bending of tunneling barrier conduction band. These devices can obtain low effective electron temperatures of less than or equal to 45K at room temperature, steep electrical current turn-on/turn-off capabilities with a steepness of less than or equal to 10 mV/decade at room temperature, subthreshold swings of less than or equal to 10 mV/decade at room temperature, and/or supply voltages of less than or equal to 0.1 V.

Abstract: A method and apparatus for accessing an enterprise resource planning system via a mobile device is described. In one embodiment, the method includes parsing data from a host application access application into at least one object in an application-specific format, converting the data into an intermediate format that is compatible with a mobile device and communicating the converted data to the mobile device.

Abstract: The present disclosure provides a cache cleaning method, a cache cleaning apparatus and a client, which improves a cache cleaning efficiency in a client and improves a user experience effectively. The method includes: detecting an amount of used caches in a mobile terminal; if the amount of used caches is larger than a preset threshold, sending a cache application request to an operating system of the mobile terminal so as to trigger a preset cache release rule in the operating system; and after the operating system releases corresponding caches according to the preset cache release rule, sending a cache release request to the operating system such that the operating system releases caches allocated for the cache application request according to the cache release request. The present disclosure may be used in a cache management technique of a mobile terminal.

Abstract: Embodiments of the present disclosure disclose a display apparatus and a method of manufacturing the display apparatus. A display panel includes a liquid crystal cell, a lower polarization filter, and a layer of which at least a pair of edges protrude beyond the liquid crystal cell. Adhesive layers are disposed on side surfaces of the display module. In any one of the side surfaces of the display module, the adhesive layer is adhered to side surfaces of the backlight module, of the lower polarization filter, and of the liquid crystal cell, and a surface, facing towards the backlight module, of the edge of the layer protruding beyond the liquid crystal cell, and has a thickness in a direction perpendicular to the side surface of the liquid crystal cell to which the adhesive layer is adhered, and the thickness is less than or equal to a selected thickness.

Abstract: A wireless device, such as an wireless access point, receives signals detected by a plurality of antennas of a wireless device to produce a plurality of antenna-specific receive signals potentially representing a wireless transmission received from each of one or a plurality of devices. A signal processing component of the wireless device, such as a modem, performs several operations on the antenna-specific receive signals, including building a first space-time equalizer to be applied to the plurality of antenna-specific receive signals to recover a transmission from a first device by both equalizing channel effects and canceling out effects associated with transmissions from devices other than the first device, and building a second space-time equalizer to be applied to the plurality of antenna-specific receive signals to recover a transmission from a second device by both equalizing channel effects and canceling out effects associated with transmissions from devices other than the second device.

Abstract: A pixel circuit and driving method, an array substrate, a display panel, and a display device are provided. The pixel circuit includes a voltage clamping unit, an energy storage unit, and a reference voltage terminal. The voltage clamping unit connects to the reference voltage terminal and a first terminal of the energy storage unit. The voltage clamping unit forms a voltage divider circuit to supply a divided reference voltage from the reference voltage terminal to the first terminal of the energy storage unit or pulls and clamps the voltage at the first terminal of the energy storage unit to a reference voltage at the reference voltage terminal.

Abstract: Methods and systems are provided for allocating resources including VoIP (voice over Internet Protocol) and Non-VoIP resources. In some embodiments, multiplexing schemes are provided for use with OFDMA (orthogonal frequency division multiplexing access) systems, for example for use in transmitting VoIP traffic. In some embodiments, various HARQ (Hybrid Automatic request) techniques are provided for use with OFDMA systems. In various embodiments, there are provided methods and systems for dealing with issues such as Handling non-full rate vocoder frames, VoIP packet jitter handling, VoIP capacity increasing schemes, persistent and non-persistent assignment of resources in OFDMA systems.

Abstract: Membranes of the present disclosure possess very thin barrier layers, with high selectivity, high throughput, low fouling, and are long lasting. The membranes include graphene and/or graphene oxide barrier layers on a nanofibrous supporting scaffold. Methods for forming these membranes, as well as uses thereof, are also provided. In embodiments, an article of the present disclosure includes a nanofibrous scaffold; at least a first layer of nanoporous graphene, nanoporous graphene oxide, or combinations thereof on at least a portion of a surface of the nanofibrous scaffold; an additive such as crosslinking agents and/or particles on an outer surface of the at least first layer of nanoporous graphene, nanoporous graphene oxide, or combinations thereof.

Abstract: A coin-operated washing/drying machine including a cabinet and a coin box assembly disposed within the cabinet. A supporting structure is fixedly disposed within the cabinet. At least a bottom surface of the coin box assembly is fixedly connected with the supporting structure by a fastener. The fastener passes through from the interior of the coin box assembly and is fixedly connected with the supporting structure. The supporting structure is disposed within the cabinet; the bottom surface of the coin box assembly is fixedly connected with the supporting structure; the fasteners such as screws are thus invisible from an overall appearance. Since the coin box assembly is fixed to the supporting structure by the bottom surface to cause such a fixing structure to be hidden in the bottom surface of the coin box assembly, thereby achieving a good anti-theft effect.

Abstract: The present invention provides inhibitors and/or antagonists of plasma kallikrein. Also provided are methods of utilizing the inhibitors as therapeutics.

Abstract: A method and system are provided having an uplink control structure and a pilot signal having minimal signal overhead for providing channel estimation and data demodulation in a wireless communication network. The uplink control structures enable mobile terminals to communicate with corresponding base stations to perform various functions including obtaining initial system access, submitting a bandwidth request, triggering a continuation of negotiated service, or providing a proposed allocation re-configuration header. A dedicated random access channel is provided to communicatively couple the base station and the mobile terminal so that the mobile terminal can select a random access signaling identification. A resource request is received at the base station to uplink resource information from the mobile terminal and an initial access information request is received from the mobile terminal to configure the base station connection.

Abstract: Provided herein are systems and methods for cooling an electric drivetrain of an electric vehicle. The electric drivetrain can include an inverter, a gearbox and a motor. A first cooling system can use ethylene glycol and water (EGW) based coolant, and can include an EGW coolant loop to distribute the EGW based coolant to remove heat from a cold plate of the inverter, a housing of the gearbox, and a housing of the motor. A second cooling system can use an oil based coolant, and can include an oil coolant loop to distribute the oil based coolant to remove heat from internal components and the housing of the gearbox, and to remove heat from internal components and the housing of the motor. The second cooling system can include an oil coolant pump to control a flow of the oil based coolant through the oil coolant loop.

Abstract: Vaccine compositions useful for vaccination against a target influenza strain, and method and kits for using the same. The vaccines comprise a live attenuated influenza virus that is synthetically constructed based upon a backbone platform derived from a bat influenza strain, and heterologous surface proteins HA and NA derived from the target influenza strain. The live attenuated virus is non-reassortant with native, circulating influenza strains, and can be used to create vaccines for humans and other animals.

Abstract: The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.

Abstract: The present invention provides a microfluidic device and its use for cell motility classification. The microfluidic device comprises a fluid inlet, a sample inlet and a channel connecting the fluid inlet and the sample inlet, wherein the channel comprises at least two sections of different sizes, and the channel allows fluid flow from the fluid inlet to the sample inlet.