Abstract: The purpose of the invention is to provide a novel hematopoiesis-promoting agent and a medicament comprising the hematopoiesis-promoting agent as an active ingredient for preventing or treating anemia, in particular refractory anemia. The present invention provides a hematopoiesis-promoting agent comprising an S-adenosylmethionine synthase inhibitor.

Abstract: A method and apparatus for receiving a notification of missing packets include receiving a set of data packets transmitted by a device and having a corresponding set of sequence numbers, identifying one or more data packets having corresponding sequence numbers that fall within the set of sequence numbers and are yet to be received, receiving an indication from the device that the one or more data packets will not be transmitted by the device, and processing the set of data packets without the one or more data packets in response to receiving the indication.

Abstract: A display device includes a pixel disposed in a display region. The pixel includes a light-emitting element connected between a first power source and a second power source; a first transistor connected between the first power source and the light-emitting element to control a driving current flowing in the light-emitting element in response to a voltage of a first node; and at least one switching transistor to transmit a data signal or a voltage of an initialization power source to the first node. The switching transistor includes a first channel region, a first conductive region and a second conductive region which are respectively disposed at opposite sides of the first channel region, and a first wide band-gap region disposed between the first channel region and the second conductive region.

Abstract: Described herein are methods of treatment of cancer by administering a therapeutically effective amount of a cytotoxic alkylating agent and a nanoparticle formulation containing an inhibitor of poly (ADP-ribose) polymerase 1. Also disclosed are treatment regimens involving parenteral administration of a therapeutically effective amount of a cytotoxic alkylating agent and a nanoparticle formulation containing an inhibitor of poly (ADP-ribose) polymerase 1.

Abstract: Provided are various embodiments relating to feline erythropoietin (EPO) polypeptide analogs with one or more additional glycosylation sites and methods of producing and using the same to treat anemia in companion animals. Also provided are various embodiments relating to EPO polypeptides having a mutation in the second binding site, polypeptides comprising an extracellular domain of EPO receptor, and methods of using the same for treating polycythemia in mammals.

Abstract: The present disclosure relates to novel, scalable methods of making substituted tricyclic compounds that are useful to treat and/or prevent HBV and/or HBV-HDV infection and related conditions in a subject.

Abstract: An eyeglass clip includes a first arm including a distal portion; a proximal portion; and a contact portion interconnecting the distal portion and the proximal portion, wherein a first bend is defined between the proximal portion and the contact portion and a second bend is defined between the distal portion and the contact portion; a second arm adjacent to the first arm, the second arm defining a free end, the second arm being planar wherein the free end of the first arm and the free end of the second arm diverge from one another; and a return bend connecting the first arm and the second arm at an end opposite to the free end of each of the first arm and second arm, the return bend defining an eyelet between the first arm and the second arm. The contact portion of the first arm is parallel to the second arm.

Abstract: A method of manufacturing a three-dimensional article includes: (1) Loading a metal platen into a build chamber, the metal platen defines an upper surface; (2) Performing concurrent processes including operating a movement mechanism to vertically translate the platen, operating a laser system to impinge a radiation beam upon the upper surface of the platen, and receiving a signal from an acoustic sensor that is positioned within the build chamber; (3) Analyzing the signal including determining a height of optimal laser convergence for the platen; and (4) Based upon the analysis, adjusting the laser convergence height to a build plane height.

Abstract: An elastomeric composition is disclosed. The elastomeric composition includes, per 100 parts by weight of rubber (phr): about 30 to about 50 phr of polybutadiene having a cis-1,4 linkage content of at least 95%; about 40 to about 70 phr of styrene/butadiene copolymer; about 0 to about 20 phr of natural rubber or polyisoprene; about 0 to about 30 phr of a processing oil; about 10 to about 30 phr of a hydrocarbon resin; about 50 to about 75 phr of a filler; a curative agent; an antioxidant; a silane coupling agent; and about 5 to about 30 phr of a butyl copolymer rubber containing about 85 to about 99.5 mol % C4-C7 isoolefin(s) and from about 0.5 to about 15 mol % C4-C14 conjugated dienes.

Abstract: An optical filter comprises an array of waveguides fabricated on an optical integrated circuit (PIC). The array comprises individual waveguides, each of which receive light inputs, e.g., individual taps of a multi-tap optical filter used in an interference cancellation circuit. Typically, the output(s) of the individual waveguides are located at an exit (edge) of the PIC. At least one second waveguide in the array is patterned on the PIC in a converged configuration such that the light transiting these waveguides co-propagates and interacts across given portions of the respective waveguides before exiting the waveguide array along a common facet, thereby generating or inhibiting one of intermodulation products, and harmonics. This structural configuration enables the generation of various modes of transmission at the PIC exit, enabling more efficient transfer of the energy, e.g., to an associated photodetector (PD) that provides conversion of the energy to the RF domain.

Abstract: The disclosed exemplary embodiments include computer-implemented systems, apparatuses, and processes that dynamically implement and manage hash-based consent and permissioning protocols. By way of example, an apparatus may obtain consent data that identifies one or more elements of data accessible to an application program executed by a device. The apparatus may generate a consent document for the application program based on at least a portion of the consent data, and may compute a consent hash value representative of the consent document. The apparatus may also generate and transmit permissioning data that includes at least the consent hash value to the device. The permissioning data may, for example, include information that instructs the executed application program to store the consent hash value within a local memory of the device and to associate the consent hash value with an access token of the executed application program.

Abstract: Example implementations relate to concurrent alternating-current and direct-current. In one example, a device comprises a power module connected to a first power outlet, the power module connected to a second power outlet, and a controller to the power module to concurrently provide alternating-current (AC) power to the first power outlet and direct-current (DC) power to the second power outlet by switching a transistor including switching circuitry in response to an absence of AC input power to the device.

Abstract: Methods for providing an acidizing treatment and stabilizing a fracture in a subterranean formation in the same treatment are described. The methods relate to acid generating agents, which generate an acid in situ and to curing or crosslinking an acid-catalyzed, curable resin with an in situ generated acid. The method further comprises the steps of introducing a first treatment fluid comprising a first base fluid and an in situ acid generating agent into the subterranean formation; and introducing a second treatment fluid comprising a second base fluid and an acid-catalyzed, curable resin into the subterranean formation.

Abstract: Embodiments presented herein are directed to radio frequency (RF) grounding in process chambers. In one embodiment, a dielectric plate is disposed between a chamber body and a lid of a process chamber. The dielectric plate extends laterally into a volume defined by the chamber body and the lid. A substrate support is disposed in the volume opposite the lid. The substrate support includes a support body disposed on a stem. The support body includes a central region and a peripheral region. The peripheral region is radially outward of the central region. The central region has a thickness less than a thickness of the peripheral region. A flange is disposed adjacent to a bottom surface of the peripheral region. The flange extends radially outward from an outer edge of the peripheral region. A bellows is disposed on the flange and configured to sealingly couple to the dielectric plate.

Abstract: Provided are improved fungal strains and use thereof, wherein the fungal strains are capable of producing an altered level of proteins, enzymes, variants and other substances of interest.

Abstract: Features are disclosed for accurately authenticating a delivery agent for unattended delivery of an item. The systems and methods described confirm the location of the delivery agent and proximity to the delivery location using short range wireless communications between a monitoring device at the delivery location and a communication device associated with the delivery agent. Access may also be conditioned on user specified “do not disturb” rules indicating when remote access is authorized. The authentication may be dynamically assessed such as based on a type of item being delivered.

Abstract: Methods of encoding and decoding for video data are described in which multi-level significance maps are used in the encoding and decoding processes. The significant-coefficient flags that form the significance map are grouped into contiguous groups, and a significant-coefficient-group flag signifies for each group whether that group contains no non-zero significant-coefficient flags. If there are no non-zero significant-coefficient flags in the group, then the significant-coefficient-group flag is set to zero. The set of significant-coefficient-group flags is encoded in the bitstream. Any significant-coefficient flags that fall within a group that has a significant-coefficient-group flag that is non-zero are encoded in the bitstream, whereas significant-coefficient flags that fall within a group that has a significant-coefficient-group flag that is zero are not encoded in the bitstream.

Abstract: A system for improving the overall performance of an energy generation system to a home includes an engagement platform, an energy generation system, an electronic device, and a home digital assistant. By drawing data across a disparate array of sources, including data from before the energy generation system is put online, the system generates and provides users and components of the energy generation system with personalized interactions, thereby effecting improvements in energy efficiency beyond those realized in behavior-agnostic control and monitoring systems.

Abstract: An improved aerosol dispensing apparatus includes an aerosol container, a discharge piece movably mounted to the aerosol container, a flow control valve mounted within the discharge piece, a battery, and an electronically controlled metering valve electronically connected to the battery and in fluid communication with the flow control valve. The flow control valve is movable between an open position wherein a volume of an aerosol formulation is directed from the aerosol container through the flow control valve to the metering valve, and a closed position, wherein the metering valve is configured to precisely control a flow of the aerosol formulation outward of the discharge piece. A solenoid is electronically connected to the battery and is movable between an actuated position wherein the solenoid urges the flow control valve into the open position, and an un-actuated position wherein the flow control valve remains in the closed position.

Abstract: Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.