Abstract: In certain embodiments novel PAC1 receptor agonists are provided wherein the agonists comprise a targeting sequence that binds to the PAC1 receptor and said targeting sequence is attached to an amino acid sequence comprising a fragment of the maxadilan amino acid sequence, wherein the targeting sequence comprises a full-length 38 amino acid PACAP peptide or an N-terminus fragment thereof containing the amino acid sequence HSDGIF, wherein said targeting sequence optionally comprises an amino acid insertion between residues 11 and 12 of said PACAP peptide or fragment thereof; and the fragment of the maxadilan amino acid sequence comprises a fragment of the maxadilan sequence effective to activate PAC1 signaling.

Abstract: A protective helmet apparatus of modular construction to be worn by anesthetized patients for facial support during surgery. The helmet apparatus is assembled using one of a plurality of interchangeable, substantially transparent helmet casings, which are removably attachable to a plurality of dismountable facial cushions providing even support to the facial surface of a patient. The removable facial cushions are dimensioned on and interior surface to accommodate different sized facial structures of different patients to yield maximum pressure diffusion on the face and chin of the patient and are replaceable when worn. The exterior surface of the facial cushions are dimensioned for cooperative engagement with the interior surface of the helmet casing. A plurality of different facial cushions and helmet casings are modular in design and dimension to be interchangeable with each other thus providing accommodate the broad differences in facial structure and size of patients using them for surgery.