Abstract: A method for the enzymatically catalyzed synthesis of a diol from an amino acid includes enzymatically hydroxylating the amino acid, enzymatically deaminating the amino acid, the deamination resulting in the formation of an oxo group at the position of the amino group, enzymatically decarboxylating the amino acid, and enzymatically hydrogenating the oxo group resulting from the deamination reaction.

Abstract: Provided is a genetically modified microorganism for the production of a derivative of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate, the microorganism further having a gene coding for a mutant phosphoserine aminotransferase having an improved L-homoserine aminotransferase activity converting by transamination L-homoserine into 4-hydroxy-2-ketobutyrate. Also provided is a method for the production of derivatives of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate by culturing the genetically modified microorganism in a culture medium and recovering the desired derivative.

Abstract: The present invention concerns a genetically modified microorganism for the production of a derivative of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate, said microorganism further comprising a gene coding for a mutant phosphoserine aminotransferase having an improved L-homoserine aminotransferase activity converting by transamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate selected in the group consisting of 1,3-propanediol, 3-hydroxypropionaldehyde, 3-hydroxypropionate and 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a culture medium and recovering the desired derivative.

Abstract: A biotechnological production of tryptophan and derivatives thereof, as well as a method for an enhanced microbial L-tryptophan synthesis. In one aspect the invention provides a bacterial cell being genetically modified to express anindole-3-glycerol phosphate synthase, IGPs, the IGPs being less sensitive to inhibition or even being activated by anthranilate compared to the wild type IGPs of the bacterial cell.

Abstract: A biotechnological production of tryptophan and derivatives thereof, as well as a method for an enhanced microbial L-tryptophan synthesis. In one aspect the invention provides a bacterial cell being genetically modified to express anindole-3-glycerol phosphate synthase, IGPs, the IGPs being less sensitive to inhibition or even being activated by anthranilate compared to the wild type IGPs of the bacterial cell.

Abstract: The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.

Abstract: The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.

Abstract: The process according to the invention for the microbial production of a specific product and methane comprises the following steps: a) the production in a bioreactor (2, 10) of a specific product from a specific substrate using a specific organism, the producer, wherein during the production of this product metabolites such as e.g. low-molecular alcohols, aldehydes and acids, hydrogen and CO2, which may inhibit the production of the product, are obtained; and b) the production of methane by means of a methanogen, wherein in the production of the methane at least one metabolite is decomposed and by this means removed from the bioreactor (2, 10) and its energy is made usable.

Abstract: The process according to the invention for the microbial production of a specific product and methane comprises the following steps: a) the production in a bioreactor (2, 10) of a specific product from a specific substrate using a specific organism, the producer, wherein during the production of this product metabolites such as e.g. low-molecular alcohols, aldehydes and acids, hydrogen and CO2, which may inhibit the production of the product, are obtained; and b) the production of methane by means of a methanogen, wherein in the production of the methane at least one metabolite is decomposed and by this means removed from the bioreactor (2, 10) and its energy is made usable.