Abstract: A use of an intervertebral disc fibrosis-inducing substance in preparation of medication, where the medication is used for the treatment of degenerative spinal diseases. The inventors of the present disclosure make use of the pro-fibrotic effect of the intervertebral disc fibrosis-inducing substance and the auxiliary effect of the fibroblast to achieve further treatment of intervertebral disc degeneration. The simultaneous administration of the above two drugs can reasonably control the degeneration and achieve the purpose of stepped treatment, thereby having clinical transformation value. In addition, the therapy combining the intervertebral disc fibrosis-inducing substance with the cell in the present disclosure allows the treatment regimen more personalized.

Abstract: The present disclosure provides the use of a recombinant human secretory DDRGK1. Experiments demonstrate that the recombinant human secretory DDRGK1 prepared by the present disclosure can be used in the preparation of biological medicines for treating intervertebral disc degeneration, fractures or bone defects. The recombinant human secretory DDRGK1 of the present disclosure provides a promising direction for the treatment of bone related diseases and has obtained firm scientific evidence, thereby expanding the further application of recombinant human secretory DDRGK1 in clinical practice.

Abstract: The present disclosure provides the use of a recombinant human secretory DDRGK1. Experiments demonstrate that the recombinant human secretory DDRGK1 prepared by the present disclosure can be used in the preparation of biological medicines for treating intervertebral disc degeneration, fractures or bone defects. The recombinant human secretory DDRGK1 of the present disclosure provides a promising direction for the treatment of bone related diseases and has obtained firm scientific evidence, thereby expanding the further application of recombinant human secretory DDRGK1 in clinical practice.

Abstract: A computer-based method and system for establishing topic words to represent a document, the topic words being suitable for use in document retrieval. The method includes determining document keywords from the document; classifying each of the document keywords into one of a plurality of preestablished keyword classes; and selecting words as the topic words, each selected word from a different one of the preestablished keyword classes, to minimize a cost function on proposed topic words. The cost function may be a metric of dissimilarity, such as cross-entropy, between a first distribution of likelihood of appearance by the plurality of document keywords in a typical document and a second distribution of likelihood of appearance by the plurality of document keywords in a typical document, the second distribution being approximated using proposed topic words. The cost function can be a basis for sorting the priority of the documents.