Abstract: Embodiments disclose a package substrate. In an embodiment, the package substrate comprises a core, where the core comprises: a first sub-core, where the first sub-core comprises a glass and a first through glass via (TGV), and a second sub-core, where the second sub-core comprises the glass and a second TGV. In an embodiment, the first TGV directly contacts the second TGV.

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Abstract: A system for moving a portion of a patient's body including a housing having a first cavity extending along a longitudinal axis, a first distraction rod having a proximal end and a distal end, the first distraction rod and the housing being telescopically displaceable with respect to each other along the longitudinal axis, the first distraction rod having a cavity extending along the longitudinal axis, a second distraction rod having a proximal end and a distal end and configured to be telescopically displaceable from within the second cavity along the longitudinal axis, and a drive system configured to move the first distraction rod in relation to the housing and to move the second distraction rod in relation to the first distraction rod.

Abstract: A system for infusing a gas into a vascular access device may include a catheter interface, which may include a distal end, a proximal end, and a lumen extending between the distal end and the proximal end. The system may also include a connector disposed on an outer surface of the catheter interface. The connector may be configured to couple to a reservoir. The reservoir may include a housing, which may include an opening and an impermeable wall. The opening may be configured to couple to the connector of the catheter interface. The reservoir may also include a molecular precursor to a gaseous agent that is suspended in a hydrogel and disposed within the housing. The gaseous agent may be antimicrobial, antithrombogenic, or both antimicrobial and antithrombogenic.

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

Abstract: In one exemplary embodiment, a combustor liner includes a first portion extending in a substantially axial direction and a second portion that extending in the substantially axial direction. A step connects the first portion and the second portion. The step is arranged at an angle to the second portion that is less than 90°. The step has a step height defined as a distance between the first portion and the second portion. The first portion, second portion, and step are formed as a unitary ceramic component. A slot extends through the step, and a ratio of a height of the slot to a height of the step is greater than 0.66.

Abstract: A method, apparatus and system for training an embedding space for content comprehension and response includes, for each layer of a hierarchical taxonomy having at least two layers including respective words resulting in layers of varying complexity, determining a set of words associated with a layer of the hierarchical taxonomy, determining a question answer pair based on a question generated using at least one word of the set of words and at least one content domain, determining a vector representation for the generated question and for content related to the at least one content domain of the question answer pair, and embedding the question vector representation and the content vector representations into a common embedding space where vector representations that are related, are closer in the embedding space than unrelated embedded vector representations. Requests for content can then be fulfilled using the trained, common embedding space.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for generating account prioritization scores for various accounts based on experience data and organization data and providing visual representations of the account prioritization scores via a graphical user interface. In particular, in one or more embodiments, the disclosed systems organize experience data and organization data to utilize in generating the account prioritization score. Further, in some embodiments, the disclosed systems generate and provide an explanation of a key factor for the account prioritization score. Thus, the disclosed systems provide an accurate and efficient graphical user interface to enable quick comprehension of even very large datasets corresponding to various accounts.

Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

Abstract: An assembly for a gas turbine engine includes, among other things, an end wall including a main body extending between a first end portion and a second end portion to establish a seal face. The end wall includes a first attachment portion dimensioned to fixedly attach the main body to a static structure at a first attachment point. An airfoil extends radially inwardly from the end wall relative to an assembly axis. The airfoil includes an inner cavity extending between a first end portion and a second end portion, the first end portion adjacent the end wall of the airfoil. A spar member includes a spar body extending between a first end portion and a second end portion. The spar body extends at least partially through the inner cavity. The first end portion of the end wall is cantilevered from the first attachment point.

Abstract: A system for moving a portion of a patient's body including a housing having a first cavity extending along a longitudinal axis, a first distraction rod having a proximal end and a distal end, the first distraction rod and the housing being telescopically displaceable with respect to each other along the longitudinal axis, the first distraction rod having a cavity extending along the longitudinal axis, a second distraction rod having a proximal end and a distal end and configured to be telescopically displaceable from within the second cavity along the longitudinal axis, and a drive system configured to move the first distraction rod in relation to the housing and to move the second distraction rod in relation to the first distraction rod.

Abstract: Devices, systems, and methods are provided for dynamic and context-based presentation of content using streaming media applications. A method may include receiving, by a first device, a user request to search for media titles based on user context data received by a first streaming media application; identifying, from a catalog of media titles and streaming media applications, the media titles based on the user context data; identifying an advertisement campaign associated with a second streaming media application; selecting, based on the advertisement campaign and the user context data, a first media title; selecting, based on the user context data, a second media title; generating first user interface data indicative of the first media title and second user interface data indicative of the second media title; and causing presentation of the first user interface data and the second user interface data using a user interface of the first streaming media application.

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.

Abstract: A computer-implemented method of user authentication is provided. The method comprises combining, by a computer system, a user recurrent neural network with a system recurrent neural network to form a unique combined recurrent neural network. The user recurrent neural network is configured to generate a unique user key, and the system recurrent neural network is configured to generate a system key. The computer system inputs a predetermined input into the combined recurrent neural network, and the combined recurrent neural network generates a unique combined key from the input, wherein the combined key differs from both the user key and system key. The computer system then associates the combined key with a unique access authorization to authenticate a user.

Abstract: A system for infusing a gas into a vascular access device may include a catheter interface, which may include a distal end, a proximal end, and a lumen extending between the distal end and the proximal end. The system may also include a connector disposed on an outer surface of the catheter interface. The connector may be configured to couple to a reservoir. The reservoir may include a housing, which may include an opening and an impermeable wall. The opening may be configured to couple to the connector of the catheter interface. The reservoir may also include a molecular precursor to a gaseous agent that is suspended in a hydrogel and disposed within the housing. The gaseous agent may be antimicrobial, antithrombogenic, or both antimicrobial and antithrombogenic.

Abstract: This invention is generally related to modified peptidic oligomers that have an increased ability to reach the cytosol or nucleus. In some embodiments, the modified peptidic oligomer molecules deliver an associated cargo molecule to the cytosol or nucleus. Other embodiments of the invention relate to modified peptidic oligomer fusion molecules that reach the cytosol or nucleus.

Abstract: In one exemplary embodiment, a combustor liner includes a first portion extending in a substantially axial direction and a second portion that extending in the substantially axial direction. A step connects the first portion and the second portion. The step is arranged at an angle to the second portion that is less than 90°. The step has a step height defined as a distance between the first portion and the second portion. The first portion, second portion, and step are formed as a unitary ceramic component. A slot extends through the step, and a ratio of a height of the slot to a height of the step is greater than 0.66.

Abstract: Techniques for providing execution verification at an integrated circuit device are described. The integrated circuit device may include a processor core configured to execute instructions. The integrated circuit device may also include a trace block configured to extract an execution trace from the processor core, the execution trace indicating the instructions that have been executed by the processor core. The integrated circuit device may further include a verification core configured to receive the execution trace from the trace block, extract an address from a control transfer instruction in the execution trace, perform one or more checks on the address, and generate an alarm signal based on the one or more checks.

Abstract: Techniques for providing remote attestation at an integrated circuit device are described. The integrated circuit device may include a memory. The integrated circuit device may also include a write bitmap comprising a bitmap that tracks the write addresses of detected memory write operations to the memory. The integrated circuit device may further include a security subsystem configured to send one or more address ranges of interest to the write bitmap and obtain a bitmap status from the write bitmap indicating that a write address within the one or more address ranges of interest was detected.

Abstract: Embodiments of the present disclosure may generally relate to systems, apparatus, and/or processes directed to a manufacturing process flow for packages that include one or more glass layers that include patterning features, such as electrically conductive traces, RDLs, and vias within the packages. In embodiments, a package may include a glass layer with a first side and a second side opposite the first side, where the glass layer is a dielectric layer. The package may include another layer coupled with the first side of the glass layer, and a pattern on the second side of the glass layer to receive a deposited material in at least a portion of the pattern.