Patents by Inventor An-Shen Lin

An-Shen Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10098853
    Abstract: Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4?-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR? inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR? ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1? (IL-1?) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: October 16, 2018
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, Fang-Rong Chang, Tusty-Jiuan Hsieh, Suh-Hang Juo, An-Shen Lin, Ying-Chi Du
  • Publication number: 20140194474
    Abstract: Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4?-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR? inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR? ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1? (IL-1?) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).
    Type: Application
    Filed: March 10, 2014
    Publication date: July 10, 2014
    Applicant: Kaohsiung Medical University
    Inventors: Yang-Chang WU, Fang-Rong Chang, Tusty-Jiuan Hsieh, Suh-Hang Juo, An-Shen Lin, Ying-Chi Du
  • Patent number: 8481757
    Abstract: Provided herein compounds, compositions and methods useful for the treatment of malaria for a subject in need thereof, including compounds of Formula (I), Formula (II), Formula (III), Formula (IV), and Formula (V).
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: July 9, 2013
    Assignees: Georgua Tech Research Corporation, The Regents of the University of California
    Inventors: Julia M. Kubanek, Mark E. Hay, Karine G. Le Roch, E. Paige Stout, Amy L. Lane, An-Shen Lin
  • Publication number: 20130040996
    Abstract: Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4?-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR? inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR? ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1? (IL-1?) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).
    Type: Application
    Filed: August 9, 2012
    Publication date: February 14, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: YANG-CHANG WU, FANG-RONG CHANG, TUSTY-JIUAN HSIEH, SUH-HANG JUO, AN-SHEN LIN, YING-CHI DU
  • Publication number: 20110190338
    Abstract: Provided herein compounds, compositions and methods useful for the treatment of malaria for a subject in need thereof, including compounds of Formula (I), Formula (II), Formula (III), Formula (IV), and Formula (V).
    Type: Application
    Filed: February 4, 2011
    Publication date: August 4, 2011
    Inventors: Julia M. Kubanek, Mark E. Hay, Karine G. Le Roch, E. Paige Stout, Amy L. Lane, An-Shen Lin
  • Patent number: 7887856
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: February 15, 2011
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 7842721
    Abstract: A pharmaceutical composition having a cytotoxic effect to a cancer cell is provided. The pharmaceutical composition includes a flavonoid compound having a formula as wherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R1-R12 is one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar. The flavonoid compound is obtained from a chemical method being one of a total synthesis method and a semi-synthesis method.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: November 30, 2010
    Assignee: Kaohsiung Medical University
    Inventors: An-Shen Lin, Yang-Chang Wu, Kuo-Hsiung Lee, Fang-Rong Chang
  • Patent number: 7785639
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: August 31, 2010
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu
  • Publication number: 20100081832
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Application
    Filed: November 16, 2009
    Publication date: April 1, 2010
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu
  • Publication number: 20100056812
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Application
    Filed: November 16, 2009
    Publication date: March 4, 2010
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 7670630
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: March 2, 2010
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu
  • Publication number: 20090221696
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Application
    Filed: May 14, 2009
    Publication date: September 3, 2009
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu
  • Patent number: 7550160
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Grant
    Filed: June 20, 2006
    Date of Patent: June 23, 2009
    Assignee: Kaohsiung Medical University
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu
  • Publication number: 20090054516
    Abstract: A pharmaceutical composition having a cytotoxic effect to a cancer cell and a method for the same are provided. The pharmaceutical composition comprises a flavonoid compound having at least one of the following formulas: wherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and any one of R1-R12 is one selected from a group consisting of hydrogen group, hydroxyl group, C1-C20 alkyl group, C1-C20 ether group, C1-C20 ester group, carboxyl group, halogen and sugar.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 26, 2009
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yang-Chang Wu, An-Shen Lin, Kuo-Hsiung Lee, Fang-Rong Chang
  • Publication number: 20070104804
    Abstract: A composition for treating cancer cells and a preparation method therefor are provided. The novel flavonoid compounds are obtained from natural plants, and more particularly the compounds have a cytotoxicity on cancer cells.
    Type: Application
    Filed: June 20, 2006
    Publication date: May 10, 2007
    Inventors: Yang-Chang Wu, An-Shen Lin, Fang-Rong Chang, Chin-Chung Wu