Abstract: A mode converter formed by parallel tapered waveguides on a SiN platform. The waveguides form a trident structure comprising a main waveguide with an inverse taper structure, and a pair of waveguides on each side of the main waveguide. Each adjacent waveguide has a taper structure but one that is opposed to that of the main waveguide, namely, a width that gradually increases along the direction of light propagation to a larger value at an end tip thereof. The end tips of the waveguides terminate along a common input/output facet of the converter. The adjacent waveguides help to shape the mode of the light propagating through the main waveguide, in so doing enabling the converter to exhibit high coupling efficiency and polarization independence in the full optical communication bands (i.e., from O to L-band) by successfully tuning the mode shape at a chip facet. The trident mode converter enables efficient optical fiber-to-chip coupling.

Abstract: The present invention relates to a preparation obtained from an in vitro culture of undifferentiated cells of Mimosa pudica, as well as to the preparation method thereof; a cosmetic or dermatological composition comprising said preparation; and the uses thereof for the treatment of inflammatory skin conditions, as an antioxidant agent in the treatment of oxidative stress caused by environmental pollution, and as an anti-aging agent.

Abstract: Systems, devices, and methods for treating the spine are disclosed herein. Medical devices can be positioned along a subject's spine to treat various conditions and diseases. The medical device can include an actuator assembly and a clamp assembly. The actuator assembly can be positioned at an interspinous space between a superior spinous process and an inferior spinous process. The actuator assembly can be used to reconfigure the clamp assembly such that the clamp assembly clamps onto the superior and inferior spinous processes.

Abstract: Immunogenic compositions containing a human immunodeficiency virus (HIV) gp140 protein, sorbitol, polysorbate 20, and histidine buffer are described. The described immunogenic compositions are advantageous in that they are stable at refrigerated temperature for extended periods of time, and are compatible with an adjuvant. Also described are methods of using the immunogenic compositions to induce an immune response against an HIV in a subject. The immunogenic compositions can be administered alone, or in combination with one or more additional HIV antigens, or one or more adenovirus vectors encoding the one or more additional HIV antigens.

Abstract: An optical filter comprises an array of waveguides fabricated on an optical integrated circuit (PIC). The array comprises individual waveguides, each of which receive light inputs, e.g., individual taps of a multi-tap optical filter used in an interference cancellation circuit. Typically, the output(s) of the individual waveguides are located at an exit (edge) of the PIC. At least one second waveguide in the array is patterned on the PIC in a converged configuration such that the light transiting these waveguides co-propagates and interacts across given portions of the respective waveguides before exiting the waveguide array along a common facet, thereby generating or inhibiting one of intermodulation products, and harmonics. This structural configuration enables the generation of various modes of transmission at the PIC exit, enabling more efficient transfer of the energy, e.g., to an associated photodetector (PD) that provides conversion of the energy to the RF domain.

Abstract: An apparatus and method are disclosed for improving power savings by accelerating suspend and resume operations. The apparatus having a main integrated circuit, the integrated circuit having a context area, a context snooper, and a context cache, the context area configured to store context change information, the context snooper configured to monitor the context change information, and the context cache configured to store at least a portion of the context change information being monitored by the context snooper; and a memory, the memory configured to receive the at least a portion of the context change information from the context cache upon a suspend process signal to the main integrated circuit, to retain contents during the main integrated circuit suspend, and restore the at least a portion of the context change information to the context cache and/or the context area upon a resume process signal to the main integrated circuit.

Abstract: The invention relates to a compound selected from among celastrol, the derivatives thereof and the pharmaceutically acceptable salts of celastrol and its derivatives, or a composition comprising such a compound for use in the topical prevention and/or treatment of a tumour or precancerous disease of the skin.

Abstract: A capsule for a heat-not-burn (HNB) aerosol-generating device may include a first frame, a second frame, a first heater, a second heater, and/or an aerosol-forming substrate. The first frame has a first interior face and a first exterior face. In addition, the first frame defines a first opening. The first heater may be secured to the first frame so as to cover the first opening. The second frame is connected to the first frame. The second frame has a second interior face and a second exterior face. Furthermore, the second frame defines a second opening. The second heater may be secured to the second frame so as to cover the second opening. The aerosol-forming substrate may be between the first heater and the second heater.

Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In an embodiment, the main body portion, cheek retractor portion, and suction connector portion may be molded in one piece, preferably by injection molding. The main body portion has an anterior wall inside the curve and a posterior wall outside the curve, and an at least one connector connecting the anterior wall and the posterior wall. The main body portion has an anterior intervening wall and the posterior intervening wall in between the anterior and posterior walls. The anterior intervening wall and the posterior intervening walls have alternating crests and troughs.

Abstract: A perforation ball sealer for temporarily plugging a perforation in an oil or gas well comprises a polymer foam core and a shell surrounding the core formed from a solid or essentially solid second polymer. Both the core and the shell are made from slowly water-soluble polymers.

Abstract: In an example embodiment, an apparatus for making pouch products includes a conveyor system. The conveyor system includes a first receiving location along a path of the conveyor system, and a dosing location along the path of the conveyor system. The apparatus also includes a first material dispensing station configured to transfer a first material to the first receiving location. The first material includes a first elastic layer and a first support layer. The first material dispensing station includes a dispenser roller configured to hold a roll of the first material, a plurality of rollers configured to convey the first material from the dispenser roller to the first receiving location, and a stripper plate configured remove at least a portion of the first support layer from a portion of the first elastic layer.

Abstract: An optical filter comprises an array of waveguides fabricated on an optical integrated circuit (PIC). The array comprises individual waveguides, each of which receive light inputs, e.g., individual taps of a multi-tap optical filter used in an interference cancellation circuit. Each individual waveguide comprises an inlet, and an outlet. Typically, the output(s) of the individual waveguides are located at an exit (edge) of the PIC. In one embodiment, at least one second waveguide in the array is patterned on the PIC in a converged configuration such that, relative to a first waveguide, the light transiting these waveguides co-propagates and interacts across given portions of the respective waveguides before exiting the waveguide array along a common facet, thereby generating or inhibiting one of: intermodulation products, and harmonics. This structural configuration enables the generation of various modes of transmission at the PIC exit, enabling more efficient transfer of the energy, e.g.

Abstract: The invention relates to a compound selected from among celastrol, the derivatives thereof and the pharmaceutically acceptable salts of celastrol and its derivatives, or a composition comprising such a compound for use in the topical prevention and/or treatment of a tumour or precancerous disease of the skin.

Abstract: A low frequency power management bus, a method of power management of a device, and a non-transitory computer readable program code configured to execute a power management process for a device are disclosed. The power management bus including a bus, and a plurality of power nodes connected to the bus, each of the plurality of power nodes including power management control logic, a power regulator, and a power policy, and wherein the plurality of power nodes are arranged in a topology with at least one node of the plurality of nodes being designated as a super power node, the super power node configured to be connected either directly or through another power node to each of the plurality of power nodes within the topology.

Abstract: An apparatus and method are disclosed for improving power savings by accelerating suspend and resume operations. The apparatus having a main integrated circuit, the integrated circuit having a context area, a context snooper, and a context cache, the context area configured to store context change information, the context snooper configured to monitor the context change information, and the context cache configured to store at least a portion of the context change information being monitored by the context snooper; and a memory, the memory configured to receive the at least a portion of the context change information from the context cache upon a suspend process signal to the main integrated circuit, to retain contents during the main integrated circuit suspend, and restore the at least a portion of the context change information to the context cache and/or the context area upon a resume process signal to the main integrated circuit.

Abstract: The production of orbital angular momentum (OAM) using an electrically-tunable q-plate, spiral phase plate or spatial light modulator, as well as a phase mask that can act as a spatial frequency filter, provides a simple, efficient method of edge contrast in biological, objects and medical sample imaging for histological evaluation of tissue, smears, PAP and histopathological samples. An OAM instrument produces OAM situated at the Fourier plane of a 4F lens system, similar to the use of a high-pass spatial filter, allows the passage of high spatial frequencies and enables the production of an image with highly illuminated edges contrasted against a dark background for both opaque and transparent objects.

Abstract: Immunogenic compositions containing a human immunodeficiency virus (HIV) gp140 protein, sorbitol, polysorbate 20, and histidine buffer are described. The described immunogenic compositions are advantageous in that they are stable at refrigerated temperature for extended periods of time, and are compatible with an adjuvant. Also described are methods of using the immunogenic compositions to induce an immune response against an HIV in a subject. The immunogenic compositions can be administered alone, or in combination with one or more additional HIV antigens, or one or more adenovirus vectors encoding the one or more additional HIV antigens.

Abstract: A perforation ball sealer for temporarily plugging a perforation in an oil or gas well comprises a polymer foam core and a shell surrounding the core formed from a solid or essentially solid second polymer. Both the core and the shell are made from slowly water-soluble polymers.

Abstract: The present invention relates to a method for producing a crude extract enriched in pentacyclic triterpenes, including celastrol, from cells of a plant from the Celastraceae family; an enriched crude extract that can be obtained using such a method; therapeutic applications of such an extract; and pharmaceutical and dermocosmetic compositions containing such an extract.