Abstract: Functional Magnetic Resonance Imaging (fMRI) reconstruction of brain-state-specific images from slow, anatomical MRI image data. In an embodiment, for each of a plurality of stimulation sequences, an fMRI apparatus is controlled to capture a set of whole-brain image data of the same region of a subject's brain according to the stimulation sequence. Each stimulation sequence is configured to induce each of a plurality of brain states in a different sequence than any of the other stimulation sequences, and each set of whole-brain image data comprises a plurality of sub-acquisition segments. For each set of whole-brain image data, each sub-acquisition segment in the set is associated with one of the brain states. Then, for each of the brain states, a whole-brain image is reconstructed from a subset of the sub-acquisition segments, in each captured set of whole-brain image data, that are associated with the brain state.

Abstract: Functional Magnetic Resonance Imaging (fMRI) reconstruction of brain-state-specific images from slow, anatomical MRI image data. In an embodiment, for each of a plurality of stimulation sequences, an fMRI apparatus is controlled to capture a set of whole-brain image data of the same region of a subject's brain according to the stimulation sequence. Each stimulation sequence is configured to induce each of a plurality of brain states in a different sequence than any of the other stimulation sequences, and each set of whole-brain image data comprises a plurality of sub-acquisition segments. For each set of whole-brain image data, each sub-acquisition segment in the set is associated with one of the brain states. Then, for each of the brain states, a whole-brain image is reconstructed from a subset of the sub-acquisition segments, in each captured set of whole-brain image data, that are associated with the brain state.

Abstract: A surgical head support device. A head cushion supports the patient's head while the patient is lying in the prone position during surgery. An air conditioning unit is adjacent to the head cushion and provides temperature control to the head cushion. A camera is positioned for viewing the patient's face as the patient is lying in the prone position on the head cushion. A secretion container is positioned to collect discharge from the patient's nose and mouth as the patient is lying in the prone position on the head cushion. A support platform is positioned under the head cushion and provides support for the head cushion, the camera and the secretion container. A height adjustment device is positioned under the support platform and is utilized to adjust the height of the head cushion for the safety and comfort of the patient.

Abstract: A surgical head support device. A head cushion supports the patient's head while the patient is lying in the prone position during surgery. An air conditioning unit is adjacent to the head cushion and provides temperature control to the head cushion. A camera is positioned for viewing the patient's face as the patient is lying in the prone position on the head cushion. A secretion container is positioned to collect discharge from the patient's nose and mouth as the patient is lying in the prone position on the head cushion. A support platform is positioned under the head cushion and provides support for the head cushion, the camera and the secretion container. A height adjustment device is positioned under the support platform and is utilized to adjust the height of the head cushion for the safety and comfort of the patient.

Abstract: In particular, in alternative embodiments, the invention provides a combined bite block/airway/tongue depressor appliance. In alternative embodiments, appliances of the invention are used in an individual, e.g., an anesthetized patient or a patient having an electroconvulsive therapy (ECT), to maintain the airway. In alternative embodiments, appliances of the invention have a bite block and tongue depressor sufficiently asymmetrically positioned in the left- or the right-hand side of the mouth to allow additional positioning of a medical or visualizing device or an endotracheal tube into the mouth, the oral cavity, larynx or esophagus.

Abstract: The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.

Abstract: The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Abstract: The present invention is directed to benzothiadiazolylphenylalkylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, R4, R5, and R6 are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.

Abstract: This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I: The invention further provides compositions including the compounds, methods for the use of the compounds, and methods of preparation of the compounds.

Abstract: The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Abstract: The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Abstract: The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Abstract: The present invention is directed to phenylpiperazine cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

Abstract: A support for the head of a patient lying in a generally prone position. The support features a tray adapted for support on an underlying operating table surface. A plurality of pins projecting from an engagement with the tray are positioned to engage and suspend either a cushion directly or a cushion engaged in a casing. The pins may be adjusted to raise or lower the engaged cushion or casing. A mirror is also provided to view a patient's eyes through slots in the cushion and casing engaged over a patient's face.

Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, R4, R5, and R6 are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.

Abstract: A fluid warming device for warming blood and other fluids prior to introduction into a patient. The counterflow fluid bags utilize a flat counter flow pathway which provides high flow performance and ensuring uniform, gradual and energy efficient blood warming. The warming device contains a pair of opposed, identical heater elements. The guide rails of the bag align the counter flow passageway for the fluid so that the bag is spaced and located precisely between the heater elements. The heater is provided with a receptive slot down the middle, in a horizontal plane, with two different sized guide slots, one on each side of the receptive slot. A pair of guide rails, integrated into the sides of the bag, are parallel to one another providing sufficient rigidity for easy insertion of the bag, and being sized to allow easy insertion in only the correct orientation. The blood warmer preferably incorporates a microprocessor for precise control of the electric current provided to the heater.